Minichromosome maintenance (MCM)
Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma
... Background: Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human ...
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Evaluation of Minichromosome Maintenance-3 (MCM3) in Oral Squamous Cell Carcinoma
... minichromosome maintenance protein family with a critical role in initiation of DNA replication. [14] It is present during cellular proliferation of normal cells, premalignant and neoplastic cells but ...
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Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog
... ABSTRACT The mammalian Mcm-domain containing 2 (Mcmdc2) gene encodes a protein of unknown function that is homologous to the minichromosome maintenance family of DNA replication licensing and helicase ...
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Complete In Vitro Reconstitution of Adeno-Associated Virus DNA Replication Requires the Minichromosome Maintenance Complex Proteins
... Adeno-associated virus (AAV) replicates its DNA exclusively by a leading-strand DNA replication mecha- nism and requires coinfection with a helper virus, such as adenovirus, to achieve a productive infection. In previous ...
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The Role of the Pre-Sensor 1 β Hairpin in Minichromosome Maintenance 2-7 Function
... DNA replication is a crucial biological process that ensures each divided cell contains a copy of their genome. This biological process is tightly regulated allowing DNA replication to occur only once during the S phase ...
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Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa
... Background: Minichromosome maintenance (Mcm) proteins are essential for eukaryotic DNA replica- tion, and their expression implies potential for cell ...
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Expression and clinical significance of the proliferation marker minichromosome maintenance protein 2 (Mcm2) in diffuse astrocytomas WHO grade II
... There is a continuous search for more specific markers, and the proliferative-associated minichromosome maintenance proteins 2–7 (Mcm 2–7) appear promising. They consti- tute an important role in regulating ...
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Original Article Minichromosome maintenance complex facilitates the recruitment of BRCA1 onto chromatin and foci formation in A549 cells
... The minichromosome maintenance (MCM) complex is an important replicative helicase in archaea and eukarya [12, 13]. The complex is composed of six related subunits (MCM2 to MCM7), which is necessary for ...
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DNA induces conformational changes in a recombinant human minichromosome maintenance complex
... one of the main model organisms for eukaryotic DNA replica- tion, the yeast Saccharomyces cerevisiae, has a closed mitosis that requires replication proteins to cross the nuclear envelope in a manner not required in ...
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Expression of minichromosome maintenance genes in renal cell carcinoma
... Abstract: Minichromosome maintenance (MCM) proteins play an essential role in DNA replication. They have been shown to be overexpressed in various types of cancer. However, the role of this family in renal ...
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Original Article Expression of minichromosome maintenance 8 in chronic myelogenous leukemia
... Abstract: Objectives: Minichromosome maintenance 8 (MCM8) is identified as an initiating helicase involved in DNA elongation and involved in cancer. However, little information is available for the role of ...
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Different Phenotypes in Vivo Are Associated With ATPase Motif Mutations in Schizosaccharomyces pombe Minichromosome Maintenance Proteins
... Ishimi, Y., 1997 A DNA helicase activity is associated with an MCM4, body, Magdalena Benzanilla for her advice with purifying recombinant -6, and -7 protein complex. J. Biol. Chem. 272: 24508–24513. proteins, and Wei ...
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Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
... protein Minichromosome Maintenance 3 (MCM3) was upregulated in HCC tissues and cells, patients with high MCM3 expression had poor outcome, it was an independent prognostic factor for ...
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Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy
... Through a comprehensive analysis of MCM genes, we observed that MCM2–7 were upregulated in PC tumor tissues, and mRNA expression of MCM4 may serve as an independent prognostic indic[r] ...
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DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex
... some maintenance (MCM) complexes and their yeast hetero- hexameric counterparts, but in higher eukaryotes such as Drosophila, MCM-associated DNA helicase activity has been observed only in the context of a ...
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Original Article Expression and prognostic significance of MCM-3 and MCM-7 in salivary adenoid cystic carcinoma
... investigate minichromosome maintenance protein 3 (MCM3) and minichromosome maintenance protein 7 (MCM7) expression in salivary adenoid cystic carcinoma (SACC) samples, and to evaluate the ...
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Next generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank
... MCM: minichromosome maintenance; MORE: Multiple Outcomes of Raloxifene Evaluation; mRNA: messenger RNA; MT: microtubule; NB: negative binomial; NCI: National Cancer Institute; NSABP-P1: The National ...
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Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication
... replication/ maintenance, we generated a recombinant KSHV with a deletion of aa 1100 to 1150 of LANA (BAC16Δ1100 –1150) through homologous recombination-based two-step BAC recombineering ...
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Potential clinical applications of antibodies against the minichromosome maintenance (MCM) proteins
... Moreover, neoplastic cells can be easily identified in all eight faecal manual smears and five out of six bead complex preparations from patients with colorectal car[r] ...
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The Role of the Carboxyterminal Domain of RNA Polymerase II in Regulating Origins of DNA Replication in Saccharomyces cerevisiae
... (minichromosome maintenance) proteins function as a replication licensing factor (RLF-M), which contributes to limiting initiation of DNA replication to once per cell ...improves maintenance of ...
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