Minor histocompatibility antigen
Identification of an immunodominant mouse minor histocompatibility antigen (MiHA) T cell response to a single dominant MiHA causes graft versus host disease
... dominant minor histocompatibility antigen, ( b ) iden- tify this peptide as a potential target of graft-versus-host disease and, ( c ) more importantly, demonstrate that a single dominant ...
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Transfusion of minor histocompatibility antigen–mismatched platelets induces rejection of bone marrow transplants in mice
... for minor histocompat- ibility antigens, such as those carried by platelets, and we report that transfusion of minor histocompatibility antigen–mismatched platelets induced subsequent BMT ...
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Recognition of a B cell leukemia associated minor histocompatibility antigen by cytotoxic T lymphocytes.
... Abbreviations used in this paper: mHag, minor histocompatibility antigen; BMT, bone marrow transplantation; CVHD, graft-vs-host disease; GVL, grafl-vs- leukemia; B-ALL, B-[r] ...
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Minor Histocompatibility antigen matching: actual fact or wishful thinking?
... Second, the MHC encoded TAP1 and TAP2 gene products are required for mHag peptide presentation on the cell surface. The transporter genes TAP1 and TAP2 associated with artigen presentati[r] ...
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Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen specific T cells in culture
... Allogenic hematopoietic stem cell transplantation (HSCT) can cure hematological malignancies refractory to cyto- toxic therapy. The therapeutic potential of HSCT largely depends on the so-called graft-versus-leukemia ...
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The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains.
... (C) The pattern of PCR amplification of genomic DNA from strain 129/J bearing the original p mutation compared with those of common laboratory strains and wild mouse isolat[r] ...
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C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.
... Most peptides that bind to HLA-A*0201 satisfy a sequence motif characterized by residues with aliphatic side chains at position 2 and at the C-terminus (22, 23). To determine if the peptide sequences encoded by the ...
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Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... whether minor histocompatibility (mH) antigen-specific cytotoxic T lymphocytes (CTL) can discriminate between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML patients, the HPC ...
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Minor Histocompatibility Antigen HA-1 Frequency and Acute GVHD in Some Hematopoietic Stem Sell Transplanted Iranian Patients
... HY is an HLA‐A2 restricted minor histocompatibility antigen (11). The immune system of females is capable to recognize and react against this male‐specific minor histocompatibility ...
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Minor histocompatibility antigen H Y is expressed on human hematopoietic progenitor cells
... contrast, inhibition of relatively mature erythroid and myeloid progenitor cells was only 40- 50%, indicating that the recognition of the H-Y antigen diminished during maturation of erythroid and myeloid HPC. Our ...
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Identification of a Graft-versus-Host Disease-associated human minor Histocompatibility antigen.
... To identify the naturally processed pep- tide epitope, we synthesized four peptides with I or L at positions 2 and 6 Microcap- dlary HPLC coelution studies revealed that three of these s[r] ...
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Induction of minor Histocompatibility antigen specific T helper, but not T cytotoxic response is dependent on the source of antigen presentation cells.
... Unlike the posttransplant T-cell lines induced with host PBLs, none of the T-cell cultures induced with host EBV-LCLs as APCs showed proliferative activity against host PBLs as stimulato[r] ...
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Multiple minor histocompatibility antigen disparities between a recipient and four HLA-identical potential sibling donors for bone marrow transplantation.
... ABSTRACT: Α pacient with acute leukemia and her family including four HLA-identical sibüngs were ana- lyzed to select a donor who was not only HLA- but also minor histocompatibility (mH[r] ...
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Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell–mediated graft versus host disease model
... Although there was minimal evidence of acute GVHD in the skin of [BALB.B→B6] chimeric recipients, by day 90 at the conclusion of the experiment, a significant increase in the deposition of thick collagen bundles in the ...
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A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
... Additional file 1: Initial donor T cell proliferation and migration after allogeneic hematopoietic cell transplantation (allo-HCT) follows the same spatiotemporal pattern but differs in bioluminescence imaging (BLI) ...
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Antigen induced monocyte procoagulant activity Requirement for antigen presentation and histocompatibility leukocyte antigen DR molecules
... sensitizing antigen had the same PCA as control ...with antigen were unable to elicit a PCA response from monocytes to which they were ...with antigen, then washed free of unbound protein, were able ...
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Conservation of minor Histocompatibility antigens between human and non-human primates.
... served in evolution [8] Howevei until now no lnioima- tion existed on the evolutionary conseivation of human non-sex hnked mHag In the present study we investig ated whether the human no[r] ...
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Multiple sclerosis: major histocompatibility complexity and antigen presentation
... This conspicuous fact has drawn little attention. Animal models simply transgenic for HLA-DRB1*1501 seem increasingly irrelevant for the study of the human disease because of it [12]. Indeed, it has recently been shown ...
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HLA class II restricted minor histocompatibility antigens - identification, processing and biology
... major histocompatibility complex (MHC) is a dominant factor in the occurrence of GvHD, and that the degree of HLA- mismatching correlated with the incidence of ...
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TARGETING TOOLS FOR A DNA VACCINE CARRIER, A DESIGN IN PREVENTION OF CANCER
... For a successful vaccination, usually dendritic cells play a great role as APC (antigen presenting cell) to activate naïve CD4 T-Cell and CD8 T-Cell, thereby Immunization against disease. Recent decade molecular ...
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