miR-139
Original Article Imatinib mesylate induces apoptosis of K562 cell by down-regulating miR-139
... Some novel findings have been demonstrated in this study: (1) Imatinib mesylate can inhibit the proliferation of K562 cells in both time- and dose-dependent manner. The drug also induced cell apoptosis in a similar ...
7
Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)
... with miR-139-5p lentivirus/scramble and luciferase lentivirus were injected intracranially into 5-week–old BALB/c-nude mice (Beijing Vital River Laboratory Animal Technology ...
13
miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52
... incubated at 37 ° C for 24 hours. Medium was removed and 500 μ L of fresh medium was added, then 500 μ L of serum- and antibiotics-free medium containing miR-139- 5p mimics, NC or TPD52 siRNA and ...
10
LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p
... In summary, the present study provided evidence that LINC00152 is upregulated in OSCC tissues, and its expres- sion is associated with TNM stage, lymph node metastasis, and poor survival of patients with OSCC. Knockdown ...
10
MiR-139-5p/SLC7A11 Inhibits the Proliferation and Migration of Pancreatic Carcinoma via PI3K/Akt Signaling Pathway
... of miR-139-5p on proliferation, migration and invasion of PANC-1 and Bx-PC3 cancer ...of miR-139-5p significantly reduced the viability of both types of cells (Figure 3A, ...of ...
25
<p>LncSNHG3/miR-139-5p/BMI1 axis regulates proliferation, migration, and invasion in hepatocellular carcinoma</p>
... while miR-139-5p was ...or miR-139-5p overexpression could inhibit the proliferation, migration, and invasion in HCC ...that miR-139-5p was a target of SNHG3, and the expression ...
16
<p>Knockdown of lncRNA TUG1 Enhances Radiosensitivity of Prostate Cancer via the TUG1/miR-139-5p/SMC1A Axis</p>
... Figure 6 Restoration of HMGB1 expression reversed the improved radiosensitivity induced by TUG1 knockdown in PCa cells. (A and B) SMC1A mRNA and protein expression were detected by qRT-PCR and Weston blot in PC-3 and ...
13
<p>miR-139 Controls Viability Of Ovarian Cancer Cells Through Apoptosis Induction And Exosome Shedding Inhibition By Targeting ATP7A</p>
... 23 MiR-139 has been previously found to repress some kinds of ...24–26 MiR-139 targeted multiple crucial genes that contribute to ...27,28 MiR- 139-5p bound to NOTCH1 and AMFR ...
11
Original Article MiR-139-5p protect against myocardial ischemia and reperfusion (I/R) injury by targeting autophagy-related 4D and inhibiting AMPK/mTOR/ULK1 pathway
... Furthermore, this study confirmed that ATG4D is the potential target gene of miR-139-5p. ATG4D is a member of cysteine aspirate prote- ase ATG4 family and widely expressed in vari- ous cellular ...
12
Tumor-suppressor role of miR-139-5p in endometrial cancer
... Quantitative real-time RT-PCR (qRT-PCR) was carried out using the protocol provided by the manufacturer. Total RNA was extracted from endometrial carcinoma tissues using TRizol reagent (Thermo Fisher Scientific, Waltham, ...
9
MiR-139-5p reverses CD44 /CD133 -associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells
... as miR-139-5p treatment (Figure 5B). These results suggested that miR-139-5p reverses CD44+/ CD133+-associated MDR by downregulating ...of miR-139-5p mimics and NOTCH1 siRNA in ...
12
<p>Long Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway</p>
... between miR-139-5p level and XIST level. Figure 2C shows the level of miR-139-5p in melanoma samples and reveals decreased miR-139-5p expression in melanoma tissues as compared ...
11
Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met
... of miR-139-5p on lung cancer is still ...of miR-139-5p on development of lung cancer. Results indicated miR-139-5p was significantly down-regulated in primary tumor tissues and ...
37
Original Article miR-139-5p suppresses the proliferation of oral squamous cellcarcinoma cells and targeting TPD52
... of miR-139-5p significantly decreased the clonogenic ability in tumor cells (Figure 3A, 3B, 3D, ...of miR-139-5p on the proliferation of OSCC cells in vivo, OC3 and OEC-M1 cells were ...
7
<p>miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling</p>
... of miR-139-5p (Figure 1C), they were further used in the subsequent cellular ...with miR-139-5p mimics ...of miR-139-5p in the two cell lines (Figure ...with ...
10
Are Changes in MicroRNAs Expression A Relevant Biomarker for Urinary Bladder Cancer Prognosis?
... species: miR-124, miR- 126, miR-139, miR-145-3p, miR-145-5p and ...occurs. miR-182 is the only representative of subgroup defined by overexpression, its oncogenic role may ...
8
Analysis of clock gene-miRNA correlation networks reveals candidate drivers in colorectal cancer
... and miR-139-5p were evaluated in the tumor tissues and adjacent non-tumor mucosa of an independent cohort of 50 CRC patients (34 men and 16 women, mean age ± SD ...and miR-139-5p expressions ...
18
Original Article MicroRNA-139-3p indicates a poor prognosis of colon cancer
... Recently, miR-139-5p has been reported to be downregulated in some types of cancer, and inhibits cancer cell invasion and ...of miR-139-3p in ...of miR-139-3p in 63 pairs of ...
7
Original Article MicroRNA-139-5p alleviates UVB-induced injuries by regulating TLR4 in si-IL-6-treated keratinocyte cells
... that miR-139-5p suppresses cells differentiation via regulating Notch and PI3K/AKT pathways in pre-adipo- cyte ...whether miR-139-5p and TLR4 affected UVB-induced cell injuries throu- gh ...
9
Original Article MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway
... apoptosis. miR-139 significantly inhibits oral cancer Tca8113 cells proliferation and induces cell ...by miR-139. miR-139 could induce Tca8113 cell apoptosis through Akt ...
7