MiR-15a/16-1
Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells
... MicroRNAs (miRNAs) are non-coding regulatory RNAs of 21 to 25 nucleotides which regulate most of basal progress such as cell proliferation, survival, apop- tosis, and differentiation by triggering either transla- tional ...
9
miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level
... by miR-15a/16- 1 [9], whether miR-15a/16-1 indirectly down-regulate Bcl-2 expression through WT1 mediated down-regula- tion of Bcl-2 is still not proved in ...
9
Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer
... them, miR-15a and miR-16-1 have the same seed sequence and exert their tumor suppressive activities through inhibiting multiple proliferative or oncogenic genes, such as Bcl-2, cyclin ...
11
miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis
... of miR-15a-3p- and miR-16- 1-3p-mediated gene silencing on the regulation of Twist1 ...of miR-15a-3p and miR-16-1-3p, and the Twist1-EMT pathway was ...
13
Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia
... of miR-15a in differentiated NZB ES cells followed the expression of Pax5, ...of miR-150 in NZB ES cells (Figure 5F), which was used as a maturation marker in this ...in miR levels were ...
14
Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
... of miR-15a was significantly lower in GC samples compared to NG subjects [27] .... MiR-15a/16-1 gene cluster locates in chromosome 13 of the human genome and mainly acts as a ...
6
MiR 15a/ 16 inhibit angiogenesis by targeting Tie2 coding sequence : therapeutic potential of a miR 15a/16 decoy system in limb ischemia
... and miR-16, which are transcribed from the miR-15a/miR-16-1 cluster, inhibit post-ischemic ...of miR-15a and -16, (2) develop an adenovirus (Ad)-based ...
14
MicroRNA-15a/16 Regulates Apoptosis of Lung Epithelial Cells After Oxidative Stress
... prepared 1 d before isolation: including 5 mL of PBS, 82 μL of anti-CD45 antibody (BD Biosciences #553076) and 32 μL of anti-CD16/32 antibody (BD Biosciences ...mL miR-15a, 15b, 16-1, ...
11
Identification of Novel Epstein-Barr Virus MicroRNA Genes from Nasopharyngeal Carcinomas
... by miR- 15a and miR-16 might inhibit the induction of lytic cycle rep- lication in the tumor ...ebv- miR-BART2 downregulates the viral DNA polymerase BALF5, resulting in reduced virus ...
9
LncRNA LUADT1 sponges miR-15a-3p to upregulate Twist1 in small cell lung cancer
... Transwell assays were performed to analyze the effects of transfections on SHP-77 and H69 cell invasion and migration. Cells were counted after trypan blue staining. Serum-free RPMI-1640 Medium (1 ml) was mixed ...
6
LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1
... to miR-15a within the 3 ′ -untranslated region (3 ′ -UTR) of human PD-L1 gene, suggesting that miR-15a might directly target ...PD-L1. MiR-15a is a well-characterized tumor ...
15
Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA 15a/16 Cluster
... including miR- 15a/16, are differentially expressed in ...of miR-15a/16 is about 10-fold lower in ...Since miR-15a/16 has been reported to target Bcl-2, ...
9
Availability of Circulating MicroRNAs as a Biomarker for Early Diagnosis of Diffuse Large B Cell Lymphoma
... hsa- miR-21, hsa-miR-155, hsa-miR-181a, and hsa-miR-210) were selected as candidate biomarkers (Table ...as miR-16, miR-39, miR-24, RNU6B, and RNU48, have ...
11
Reduction of gastric cancer proliferation and invasion by miR- 15a mediated suppression of Bmi-1 translation
... for miR-15a, miR-16, and miR-200c based on several different tumor types [31, 33, ...Bmi- 1 has been detected in several human cancers including lymphoma, acute myeloid leukemia, ...
15
Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients
... silencing 1-like (DOT1L) that catalyze methylation of histone H3 lysine 79 (H3K79) and susceptibility of AIS were found [18], the correlation between alteration of histone methylation and development of IS has not ...
13
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling
... Total RNA was isolated and purified using the TRIzol method, and the purity and quantity of RNA were mea- sured using Synergy HTX multi-mode reader (BioTek; Winooski, VT). For polyA tailing reverse-transcriptase PCR, 5 ...
9
<p>LINC00662 Long Non-Coding RNA Knockdown Attenuates the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Regulating the microRNA-15a-5p/Notch2 Axis</p>
... metastasis 1 (TIAM1). 16 MiRNA-646 inhibits the metastasis of OS cells by downregu- lating fibroblast growth factor 2 ...and miR-15a-5p in OS remains to be ...
14
Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
... HUVEC were isolated from umbilical cords obtained from the maternity unit at Meir Medical Center, Kfar Saba, Israel [13]. The Ethical Review Committee approved the study and the parturient provided written informed con- ...
11
Computational Identification of microRNA 15a predicted to regulate Brain Derived Neurotrophic Factor involved in Type 2 Diabetic Retinopathy
... diseases, miR-15a family miRNAs have been involved, therefore miR-15a acts as a biomarker for the treatment of T2DR( Lagos et ...2001). miR-15a was identified as key regulator of ...
8
FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression
... Fetal-lethal non-coding developmental regulatory RNA (FENDRR) is a new-founded lncRNA which has been reported as a tumor suppressor in different can- cers including non-small lung cancer, prostate cancer, breast cancer, ...
10