miR-17~92
A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke
... of miR-17 and miR-20a were found to associated with inhibit Hif mRNA and protein expression, this finding indicated that these two miRNAs may play role in atherosclerosis progression ...of ...
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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences
... The miR-17-92 cluster, also named oncomir-I, and its two paraloga miR-106a-363 and miR-106b-25 were among the first families of those small RNA molecules that were found to be ...
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The MYC /miR-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential
... the miR- 17-92 cluster were up-regulated upon TLR9 triggering by CpG, compared to unstimulated cells, in CLL cells bearing an unmutated BCR, whereas no difference was detected in the context of a ...
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Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts
... cells, miR-17-92 expression is high in naïve cells but diminishes as the cells differenti- ate ...infection, miR-17-92 is strongly up-regulated following T-cell activation but is ...
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The Role of Myc and the miR 17~92 Cluster in Histone Deacetylase Inhibitor Induced Apoptosis of Solid Tumors
... the miR-17~92 cluster could inhibit the growth of Myc high cells, SW620 cells were again transfected with antagomiRs to miR-18, miR-19, or miR-20 (or a scrambled control) and ...
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miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions
... pcDNA3.1-overexpressing miR-17-92 cluster; empty vector ...50-nM miR- 17, miR-20a, miR-19a, and miR-19b mimics were trans- fected into the ...
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An Analog of PKC412 Blocks Human Leukemia HEL Cells Growth Through STAT3/Mir-17-92/BIM Signal Pathway
... MiR-17-92 play an essential role in both the apoptotic and cell- proliferation pathways ...of miR-17-92 could induce up-regulation of the pro-apoptotic protein BIM by using ...
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Control of oligodendroglial cell number by the miR 17 92 cluster
... the miR-17-92 knockdown in oligodendrocytes are strikingly similar to the phenotype observed after the conditional loss of Dicer using a Cnp- Cre line ...2010). miR- 219 and miR-338 ...
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MiR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth
... identified miR-17-19b targets in l-MYC lymphomas revealed that several pathways relevant for cancer onset and maintenance are affected, including Cell Death and Cell Cycle Regulation ...known ...
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miR 17 92 expression in differentiated T cells implications for cancer immunotherapy
... from miR-17-92 TG/TG T cells compared with control cells suggest that miR-17-92 may actually promote the type-1 skewing of T cells ...As miR-17-92 targets ...
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Short stature, digit anomalies and dysmorphic facial features are associated with the duplication of miR-17 ~ 92 cluster
... ~ 92 cluster) contributes to the pathogenesis of a variety of human diseases, including cancer and congenital developmental ...the miR-17 ~ 92 polycistronic miRNA cluster, and the first five ...
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C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells
... that miR-17-92 and its paralog miR-106b-25 played an import- ant role in tumorigenesis ...the miR-17–92 cluster has been ob- served in diverse tumor subtypes, such as ...
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miR-17 promotes expansion and adhesion of human cord blood CD34+ cells in vitro
... some miR- NAs have been investigated in murine ...of miR-181 in lineage negative hematopoietic progenitor cells from mouse bone marrow increased the fraction of B lineage cells (CD19 + ) in vitro and in ...
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miR-17 regulates melanoma cell motility by inhibiting the translation of ETV1
... to miR-17 [21], is mostly considered to play an oncogenic role [22], [23], ...that miR-17 suppresses growth of cervical cancer cells and promotes their apoptosis [29], as well as inhibits the ...
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Regulation of endoderm formation and left right asymmetry by miR 92 during early zebrafish development
... the miR-17-92 cluster significantly accelerated disease onset and progression (He et ...the miR-17-92 cluster is directly regulated by c-Myc and E2F3 (O’Donnell et ...the ...
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The RNA binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR 17 activity
... remove the poly(A) tail before the RL-PCR, which collapsed the smear seen in the gel into a distinct band. (C) Schematic representation of Pkd2 constructs [Pkd2(long_UTR), Pkd2(short_UTR), Pkd2(no_UTR), ...
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Screening miRNAs for early diagnosis of colorectal cancer by small RNA deep sequencing and evaluation in a Chinese patient population
... of miR-18a-5p and miR-21-3p or downregulation of miR-133a-3p in adenoma and cancer tissues may serve as an index for early screening of colorectal ...as miR-135b-5p, miR-17-5p, ...
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Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2
... of miR-17 to induce generation of glioblastoma stem-like cells is another interesting finding of our ...that miR-17 not only increased CD133 positive cells when cultured in SFM, but also ...
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Original Article miRNA-17 promotes nasopharyngeal carcinoma radioresistance by targeting PTEN/AKT
... of miR-17-5p in the CNE2 ...hand, miR-17-5p has far more than one target in different tumor ...that miR-17-5p inhibited TIMP3 expression to induce prostate tumor growth and ...
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MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
... of miR-155 in AMLs carrying FLT3-ITD is in line with reported findings in CN-AML ...that miR- 155 is slightly up-regulated in CN-AML with NPM1+ ...of miR-155 is strictly corre- lated to FLT3+ and not ...
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