miR-17-92 cluster
The Role of Myc and the miR 17~92 Cluster in Histone Deacetylase Inhibitor Induced Apoptosis of Solid Tumors
... In recent years histone deacetylase inhibitors (HDACi’s) have emerged as promising therapeutics for cancer. While favorable responses to HDACi’s as single agents have been shown in several hematological malignancies, ...
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Control of oligodendroglial cell number by the miR 17 92 cluster
... of miR-17-92 action in oligodendrocytes, we expressed miR-17 and miR-19b in the oligodendroglial cell line, ...of miR-17-19b resulted in a greater number of Oli-neu ...
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A functional polymorphism in the promoter of miR-17-92 cluster is associated with decreased risk of ischemic stroke
... of miR-17 and miR-20a were found to associated with inhibit Hif mRNA and protein expression, this finding indicated that these two miRNAs may play role in atherosclerosis progression ...of ...
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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences
... the cluster- related miR-106a which was shown in cell lines but also in FFPE samples ...of miR-17, miR-18a, miR-92a, and miR-106b correlated with lower levels of ...the ...
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Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells
... of miR 106b-25 cluster are downregulated by 2–5 fold in LNCaP, PC-3 and DU 145 cells as compared to their expression in MDA PCa 2b cells (Figure 5A & table ...the miR 23b-24 cluster, the ...
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The MYC /miR-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential
... the miR-17-92 cluster in BL In a recent study [76], high miR-17-92 overexpression has been found in BL, thus confirming that the activation of the ...
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An Analog of PKC412 Blocks Human Leukemia HEL Cells Growth Through STAT3/Mir-17-92/BIM Signal Pathway
... MiR-17-92 play an essential role in both the apoptotic and cell- proliferation pathways ...of miR-17-92 could induce up-regulation of the pro-apoptotic protein BIM by using ...
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miR 17 92 expression in differentiated T cells implications for cancer immunotherapy
... Our miR microarray and RT-PCR analyses revealed that of all analyzed miRs, members of the miR-17-92 cluster (miR-17-92) are of the most significantly over- ...
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Regulation of endoderm formation and left right asymmetry by miR 92 during early zebrafish development
... the miR-17-92 cluster significantly accelerated disease onset and progression (He et ...the miR-17-92 cluster is directly regulated by c-Myc and E2F3 (O’Donnell et ...
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The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer
... of miR-17-92 cluster, PC-3, M12 and LNCaP 104-S cells were transfected with a modified expression vector containing a precursor clone of miR-17-92 cluster PMIRH ...
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miR-17 regulates melanoma cell motility by inhibiting the translation of ETV1
... oncogenic miR-17/92 cluster. Here we study the effect of miR-17 on melanoma cell ...of miR-17 in WM-266-4 and 624mel melanoma lines enhances cell motility, evident ...
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miR-17 promotes expansion and adhesion of human cord blood CD34+ cells in vitro
... called miR-17-5p), an important member of the miR-17-92 cluster, contains the AAAGUGC-seed sequence ...[20]. miR-17 is abundantly expressed in mur- ine ...
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C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells
... that miR-17-92 and its paralog miR-106b-25 played an import- ant role in tumorigenesis ...the miR-17–92 cluster has been ob- served in diverse tumor subtypes, such ...
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Short stature, digit anomalies and dysmorphic facial features are associated with the duplication of miR-17 ~ 92 cluster
... the miR-17 ~ 92 cluster, encodes for six individual miRNAs: MIR17, MIR18A, MIR19A, MIR20A, MIR19B1 and MIR92A1 ...The miR-17 ~ 92 miRNA cluster is located on human ...
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miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions
... that miR-17 modu- lates neuron-astrocyte transition via inhibiting BMPR2 expression ...of miR-17 in controlling neurogenic to gliogenic transition of NSCs ...that ...
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miR-17-92a-1 cluster host gene (<em>MIR17HG</em>) evaluation and response to neoadjuvant chemoradiotherapy in rectal cancer
... these miR-cluster members in determining the response to NCRT in ...If miR-19a, miR-19b-1, and miR-92 overexpression in pretherapy biopsies were confirmed to be associated with ...
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MiR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth
... identified miR-17-19b targets in l-MYC lymphomas revealed that several pathways relevant for cancer onset and maintenance are affected, including Cell Death and Cell Cycle Regulation ...known ...
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Screening miRNAs for early diagnosis of colorectal cancer by small RNA deep sequencing and evaluation in a Chinese patient population
... (Illumina Company), with reverse transcriptase polymerase chain reaction (RT-PCR) to enrich the library and with Qubit kit (Thermo Fisher Scientific) to quantify miRNA libraries. Sequencing was performed with the ...
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Functional similarities of microRNAs across different types of tissue stem cells in aging
... identified miR-17/106 family members as key regulators of the neurogenic-to- gliogenic switch in developing neural stem/progenitor cells (NSCs) by controlling the “competence” necessary for NSCs to respond ...
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The aberrant expression of microRNAs and correlations with T cell subsets in patients with immune thrombocytopenia
... 142-3p, 17-5p, 21 and 181a) and the frequencies of four Th cells (Th1, Th2, Th17 and Treg) in peripheral blood mononuclear cell (PBMCs) of ITP patients and healthy ...of miR-146a on Th differentiation was ...
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