miR-193a
Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers
... approved by the committee for humane treatment of animals at Wenzhou Medical University Institutional Guidelines. The animals were maintained under specific pathogen free (SPF) conditions in the Animal Facility, Wenzhou ...
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Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways
... while miR-193a-3p levels were evaluated by qPCR and in situ hybridization in ovarian cancer cell lines and clinical tissue ...and miR-193a-3p in ovarian cancer cells. Results: Both ...
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The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer
... the miR-193a-3p mimic and the most effective siRNA against ING5 (si-ING5-1) in terms of drug-triggered cell death is likely attributable to the downregulation of other miR- 193a-3p target ...
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Original Article A microRNA signature containing miR-1258 and miR-193a predicts survival in HER2-negative breast cancer
... cancer cells to chemotherapeutic drugs by reg- ulating the MARP signaling pathway [36, 37]. The activation of Wnt signaling and gene regu- lation mediated by microRNAs are causal fac- tors that together drive ...
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Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel
... of miR-193a-5p in the 3′- UTR of HO-1 ...whether miR-193a-5p suppresses the expression of tran- scription factors which regulate HO-1 ...with miR-193a-5p mimic significantly ...
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MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma
... microarray, miR-193a-5p was chosen for further examination (Figure 2A and Supplementary Figure ...by miR-193a-5p in KYSE cells, miR-193a-5p precursors and inhibitors were ...
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<p>LncRNA TUG1 Regulates Cell Viability and Death by Regulating miR-193a-5p/Rab10 Axis in Acute Myeloid Leukemia</p>
... of miR-193a-5p, TaqMan miRNA Reverse Transcription Kit (Applied Biosystems, Foster City, CA, USA) and all-in-one miRNA RT-qPCR Detection Kit (GeneCopoeia ...for miR-193a-5p, U6, TUG1, Rab10 ...
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<p>Long Non-Coding RNA Cancer Susceptibility 9 (CASC9) Up-Regulates the Expression of ERBB2 by Inhibiting miR-193a-5p in Colorectal Cancer</p>
... 24,25 miR-193a-5p was usually considered as an anti-cancer ...study, miR-193a-5p has been shown to inhibit the malignant phenotypes of CRC cells, thereby inhibiting the progression of ...that ...
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<p>Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression</p>
... of miR-193a-3p by bioinfor- matics analysis using the TargetScan database and miRanda ...between miR-193a-3p and the 3’UTR of MCL1 ...of miR-193a-3p mimics could reduce the ...
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Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression
... of miR-193a, protein kinase B (Akt), phosphoinositide 3-Kinase (PI3K), ceclin1, mammalian target of rapamycin (mTOR), sonic hedgehog (SHH), myosin-like Bcl2 interacting protein (LC3), smoothened (Smo), and ...
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Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer
... identify miR-193a expression profile in ...of miR-193a expression by using plasmid, lentivirus and small interfering RNA ...of miR-193a by EZH2 and ...of miR-193a ...
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<p>MiR-193a-3p inhibits pancreatic ductal adenocarcinoma cell proliferation by targeting CCND1</p>
... between miR-193a-3p and ...Therefore, miR- 193a-3p overexpression led to the PDAC cell cycle ’ s block at the G1 phase, which have been caused by inhibiting CCND1 ...after miR- ...
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Insulin-like growth factor-1-mediated regulation of miR-193a expression promotes the migration and proliferation of c-kit-positive mouse cardiac stem cells
... that miR-193a nega- tively changed c-kit expression is modulated by DNMT ...of miR-193a and c-kit was decreased by infection with a miR-193- expressing lentivirus or 5-AZA ...Moreover, ...
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Original Article Long non-coding RNA NEAT1 predicts elevated chronic obstructive pulmonary disease (COPD) susceptibility and acute exacerbation risk, and correlates with higher disease severity, inflammation, and lower miR-193a in COPD patients
... ong groups was determined by Wilcoxon rank sum test or Kruskal-Wallis test. Categorical variables were described as count (percent- age), and comparison among groups was deter- mined by Chi-square test. Spearman’s rank ...
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Expression and clinicopathological significance of miR-193a-3p and its potential target astrocyte elevated gene-1 in non-small lung cancer tissues
... [4–8]. MiR-193a is one of the miRNAs involved in carcinogenesis, which con- sists of miR-193a-3p and ...that miR-193a-3p plays essential roles in the multi- chemoresistance of ...
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miR-181c associates with tumor relapse of high grade osteosarcoma
... of miR-193a-5p, miR-181a and miR- 181c is compatible with the engagement of TGF-β- and Wnt- pathways along the GCT evolutionary malignancy of the presented ...the miR-181c ...
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<p>MicroRNA-193a-3p suppresses the colorectal cancer cell proliferation and progression through downregulating the PLAU expression</p>
... of miR-193a-3p, a gene located on human chromosome ...of miR-193a-3p as tumor suppressor in both solid and blood cancers by targeting targets with potential oncogenic functions to act its ...
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A microRNA dependent program controls p53 independent survival and chemosensitivity in human and murine squamous cell carcinoma
... these, miR-193a-5p, expression of which was repressed by p63, was activated by proapoptotic p73 isoforms in both normal cells and tumor cells in ...inhibiting miR-193a interrupted this ...
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<p>miR-140-5p alleviates the aggressive progression of Wilms’ tumor through directly targeting <em>TGFBR1</em> gene</p>
... 34 miR- NAs were identified to be differently expressed in WT tissues and the adjacent non-tumor tissues significantly (all P-values < ...that miR-141, miR-214, miR-140-5p, and ...
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microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings
... that miR-193a promoted pancreatic cancer repopu- lation and metastasis through modulating TGF-β2/TGF- βRIII signaling ...shown, miR-193a was found to be highly expressed in the irradiated ...
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