miR-20a
Expression of miR-20a: A serum biomarker in the diagnostic approach for hepatocellular carcinoma
... of miR-20a as non-invasive serum biomarker in HCC patients, but, in contrast to our findings, it was significantly correlated more with HCV-positive liver fibrosis in HCC patients than the HBV-related HCC ...
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PTENP1/miR-20a/PTEN axis contributes to breast cancer progression by regulating PTEN via PI3K/AKT pathway
... and miR-20a, whereas PTEN participated in suppressing the proliferation of cancer cells via nega- tively regulating the PI3K/Akt pathway [25, 26], which suggested that PTEN was important in malignant trans- ...
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MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma
... of miR-20a-5p, and luciferase assay validated miR-binding sequence for ...of miR-20a-5p dramatically suppressed ATG7 protein lev- els in a dose- and time-dependent ...that ...
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Original Article MiR-20a promotes cell proliferation by targeting SRCIN1 in human multiple myeloma
... While miR-20a has been shown to play important roles in several cancers, the specific functions of miR-20a in the pathogenesis of multiple myeloma (MM) remain ...the miR-20a on ...
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iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling
... The miR- 20a mimics (mimic-20a) or negative control mimic (mimic-NC), anti-miR-20a inhibitor (anti-20a), negative control inhibitor (anti-NC), siRNA targeting FBXL5 (AM16708) and ...
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Original Article MiR-20a in cell-free urine as a potential diagnostic biomarker for non-muscle invasive bladder cancer: a Chinese population-based study
... Urinary miR-20a expression was detected by qRT-PCR analy- sis, and correlated with tumor tissue miR-20a ...urinary miR-20a for NMIBC diag- ...urinary miR-20a ...
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Aberrantly Up-regulated miR-20a in Pre-eclampsic Placenta Compromised the Proliferative and Invasive Behaviors of Trophoblast Cells by Targeting Forkhead Box Protein A1
... of miR-20a to explore the mechanism underlying its effects on trophoblast cell proliferation, migration and ...of miR-20a with biological ...of miR-20a on trophoblast cell is due ...
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Restoration of miR-20a expression suppresses cell proliferation, migration, and invasion in HepG2 cells
... using miR-20-specific reverse primer to obtain cDNA (Table ...of miR-20a was determined using Fast Synergy Brands Green Master Mix method on ABI 7500 Real-time qPCR System (Thermo Fisher Scientific), ...
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MiR–20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells
... the miR‑20a‑5p’s promoting effect on the NPC radio‑resistance To explore the role of Rab27B in the NPC radio-resist- ance, we first transfected miR-20a-5p-mimic into CNE-2 cells and tested the ...
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Original Article Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury
... by miR-20a and miR-29b, respectively. To determine whether miR-20a and miR-29b play a role in neuronal apoptosis of SCI by regulating those genes, we transfected Neuro-2A ...
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MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene
... how miR-20a-5p affects chemoresist- ance regulation in OS, a luciferase reporter assay was performed to identify potential target genes of miR- ...that miR-20a-5p directly tar- geted ...
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MiR-20a-5p represses the multi-drug resistance of osteosarcoma by targeting the SDC2 gene
... of miR-20a-5p mimic or si-SDC2 in SJSA-1 cells decreased the chemoresistance to some extent against the following five drugs: Dox, Etop, MTX, CDDP, Carb, except the mimic to MTX and CDDP ...of ...
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MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
... conserved miR-20a-5p and conducted mutant miR-20a-5p and conserved mutant Smad4 3′-UTR, so miR-20a-5p with the complementary Smad4 3′UTR sites were mutated as reported previously ...
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Original Article Down-regulation of microRNA-20a in gemcitabine-resistant pancreatic cancer in in vitro microRNA integrative analysis
... Abstract: Objectives: The efficacy of gemcitabine-based chemotherapy remains limited due to drug resistance in ad- vanced pancreatic cancer. This study aims to identify microRNAs (miRNA) that are associated with such ...
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Decrease expression of microRNA-20a promotes cancer cell proliferation and predicts poor survival of hepatocellular carcinoma
... of miR-20a was signifi- cantly down-regulated in HCC tissue compared with nor- mal liver tissue (P = ...of miR-20a were further down-regulated in HCCs samples of patients with tumor recurrence ...
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Original Article Correlation research on plasma miRNA-17-5p and miRNA-20a with prognosis for pulmonary arterial hypertension
... cell miR-17-92 gene family [15]. Coding miR-17-5p and miR- 20a through corresponding miRNA gene fami- lies can specifically downregulate expression of BMPR2 proteins ...and miR- ...
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Oncogenic role of microRNA-20a in human multiple myeloma
... progression. miR-20a has been implicated in numerous ...that miR-20a was associated with Gleason score, a system to evaluate prognosis of prostate cancer, and it targets the ABL family ...
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IL-10Rα expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma
... combination, affected the transcription of the pGL3-IL- 10Rα-mut vector (Fig. 3b). When blocking the expression of the three miRNAs with specific inhibitors, luciferase in- tensity markedly increased in cells transfected ...
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Clinical impact of circulating miR-26a, miR-191, and miR-208b in plasma of patients with acute myocardial infarction
... The purpose of our study was to confirm the level of miR-26a, miR-191, and miR-208b. Some have expressed concern about the relationship between them and AMI [19, 20]. Accordingly, the detection of ...
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Association of the miR 146a, miR 149, miR 196a2 and miR 499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations
... the miR-146a C > G SNP between the pulmonary TB group and the control ...the miR-146a C > G SNP can be associated with susceptibility to pulmonary TB in the Kazak population and may increase the risk ...
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