miR-21
MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1 SOCS6 , and PTEN
... with miR-21 and miR-155 antisense sequences induced the apoptosis of A549 and H1299 cells (Figure ...with miR-21, miR-155, or miR-21/155 antagomirs (Figure ...with ...
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MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway
... Overexpressed miR-21 contributes to increased cell proliferation and a decline in apoptosis by suppressing several tumor suppressor genes including phosphatase and tensin homolog (PTEN), tropomyosin 1, ...
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<p>Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin</p>
... of miR-21 in SK-MES-1 cells (Figure 3A) and a 39-fold upregulation in exosomes (Figure ...hypoxic miR-21 mimic cells and hypoxic control mimic cells were added into the normoxic cell culture ...
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MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a
... of miR-21 overexpression on HCMV gene expres- sion and genome replication manifest at early times of infection and are largely gone by 96 hpi ...ectopic miR-21 can in time be overcome by a ...
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Original Article MiR-21 regulates TGFBI expression in breast cancer cells
... found miR-21 over- expressed in breast cancer ...that miR-21 level in breast can- cer tissue was obviously higher than that in para-carcinoma ...of miR-21 in breast cancer ...
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Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling
... to miR-21 promoter was analyzed by MyiQ™ Single-Color Real-Time PCR Detection System (Bio-Rad, Hercules, CA) with SYBR Green PCR master mix using following primer sequences, TCF4 binding to c-Myc promoter: ...
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Original Article MiR-21 expression significance in non-small cell lung cancer tissue and plasma
... test miR-21 expres- sion in the plasma from NSCLC ...(8.5%). MiR-21 level in the plasma from patients in stage III and IV was obviously higher than that in stage I and II (P < ...that ...
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Original Article Increased expression of miR-21 predicts poor prognosis in patients with hepatocellular carcinoma
... of miR- 21 is associated with the prognosis of patients with HCC is still ...that miR-21 was significantly higher in HCC tissues compared with adjacent non-tumor ...High miR-21 ...
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MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN
... of miR-21. MiR-21 has been shown to play an important role in cell proliferation and cell growth in ICC and other solid tumors from our results and in previous ...of miR-21, ...
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Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21
... of miR-21 ...of miR-21 to the TIMP3 3’UTR, and the assay showed that miR-21, compared with the control treatment, significantly suppressed the expression of Renilla luciferase ...
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MiR 21: an environmental driver of malignant melanoma?
... [3]. MiR-21 is involved in adipocyte differentiation and is upregulated in subcutaneous adipose tissue of obese individuals [210, ...murine miR-21 and induces obesity in mice [212]. ...
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miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells
... of miR-21 in AGS cells was reduced after NS398 treat- ...with miR-21 overexpression or NS398 treat- ment, and showed that increased miR-21 expression could reduce NS398-induced ...
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Modulation of miR-21 signaling by MPS1 in human glioblastoma
... of miR-21 (which targets the 3’ untranslated region of their mRNAs and represses their expression), we analyzed their levels under RNAi mediated miR-21 inhibition along with its ectopic ...
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MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior
... The glucose detection checkerboard and lactic acid checkerboard were obtained from the Jiancheng Institute of Biological Engineering (Nanjing, China). RIPA cracking liquid kits were from Biyuntian Biological Co., Ltd. ...
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miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease
... induced miR-21 expression in macrophages in a time- and dose-dependent ...of miR-21 by transfection with miR-21 mimics notably attenuated lipid accumulation and lipid-laden foam ...
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Original Article MiR-21 facilitates the proliferation of smooth muscle cells and atherosclerotic plaque formation by suppressing PTEN to activate AKT
... The MiR-21 primers were synthesized by Sig- ma (US) [11]. The sequences were: forward: 5’-TTGAA TTCTA ACACC TTCGT GGCTA CAGAG- 3’; reverse: 5’-TTAGA TCTCA TTTAT CGAGG GAAGG ATTG-3’. U6 was used as the ...
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Turning 21: Induction of miR 21 as a key switch in the inflammatory response
... increased miR-21 expression has also been reported in diseases fueled by chronic inflammation including colitis (67), atherosclerosis (40), type 2 diabetes (68), and SLE ...through miR-21 ...
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Original Article MiR-21-3p and miR-21-5p in tumor tissue as diagnostic biomarkers for gastric cancer
... both miR- 21-3p and miR-21-5p may serve as potential diagnostic biomarkers for GC, whilemiR-21-5p is more potent in distinguishing the degree of tumor ...
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The role of circulating MicroRNA-21 (miR-21) in epithelial ovarian cancer
... The plasma sample that was stored at −80°C was melted and then centrifuged at 3000 g for 5 minutes at 4°C, and as much as 200 μl were taken. Total RNA was extracted using miRCURY RNA Isolation Kit-Biofluid kit according ...
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Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor
... down-regulating miR-21 expression. The involvement of miR-21 in both carcinogenesis, by increasing the growth of breast cancer cells [16], and tumor progression and invasion [18] is well ...
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