miRNA-221
<p>miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice</p>
... when miRNA- 221-3p at a dose of ...the miRNA-221-3p – treated groups of normal (Figure 7) and diabetic (Figure 8) ...that miRNA-221-3p promotes wound heal- ing in mice and ...
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miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer
... of miRNA-221 (miR-221) in exosomes of the peripheral blood was determined to be positively correlated with the poor clinical prognosis of GC, especially with respect to tumor, node, and metastases ...
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miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN
... of miRNA-221 could target apoptotic protease acti- vating factor-1, which further promotes ovarian cancer cell proliferation and indicates a poor prognosis ...
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miRNA-221 and miRNA-222 synergistically function to promote vascular calcification
... miR- 221 and miR-222 contribute to the pathological process of vascular calci fi ...and miRNA-222 in calcifying cells, the increase in cellular miR levels synergistically act to increase levels of cellular ...
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Original Article miRNA-221 promotes proliferation, migration and invasion by targeting TIMP2 in renal cell carcinoma
... CDKN1C/p57 and CDKN1B/p27 protein expres- sion [13]. Zhang et al found that miR-221 is increased gastric carcinoma and regulate radiosensitivity and cell growth and invasion of gastric cancer cells via direct ...
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<p>Long Noncoding RNA SOCS2-AS Promotes Leukemogenesis in FLT3-ITD+ Acute Myeloid Leukemia Through miRNA-221</p>
... FLT3-ITD, STAT5 drives a wide spectrum of the pathogenesis of AML. High pY-STAT5 levels are found to be involved with prognosis in myeloid malignancies and TKI-resistance. 21 Several STAT5 inhibitors with encouraging ...
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miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6
... Total RNA was extracted using TriReagent (Sigma-Aldrich, St. Louis, MO, USA). Generation of cDNA for miRNAs of interest was performed using Taqman MicroRNA Reverse Transcription kits (Applied Biosystems, Foster City, CA, ...
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miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker
... particle/FAM-conjugated miRNA complexes with a dosage of 10 μ L of miRNA (20 μ M) per well and cultured at 37 ° ...Lipofectamine/FAM-conjugated miRNA complexes were used as positive ...
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MicroRNA-155 is a potential molecular marker of natural killer/T-cell lymphoma
... (miRNA-34a, miRNA-34b, miRNA-34c, miRNA-155, miRNA-21, miRNA-221), which were expressed at high, intermediate, and low levels in samples from the NKTCL cell lines SNK-6 ...
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Circulating microRNA-122a as a diagnostic marker for hepatocellular carcinoma
... serum miRNA-221 and miRNA-122a was measured using SYBR Green microRNA quantitative reverse transcription polymerase chain reaction reagents (CoWin Bio- tech Co, Ltd, Beijing, People’s Republic of ...
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Novel miRNA Sponges toS pecifically ModulateG ene Expression inC olon CancerC ells
... abduct miRNA molecules thanks to their sequence of multiple tandem binding sites (MBS) [42] , allowing to inhibit the expression of diverse families of miRNAs [54] ...
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<p>MicroRNA-221 promotes papillary thyroid carcinoma cells migration and invasion via targeting RECK and regulating epithelial–mesenchymal transition</p>
... abatement in relative luciferase activity, whereas activity did not drop at all in the mutant 3 ′ -UTR reporter, indicat- ing that functionality relies on the intact seed sequence. Together, these findings strongly ...
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Plasma Level of miRNA-7, miRNA-409 and miRNA-93 as Potential Biomarkers for Colorectal Cancer
... the miRNA-409 family has been shown in some cancers. Upregulation of miRNA-409-3p was found in the plasma of breast cancer patients (Cuk et ...of miRNA-409-5p was reported in both breast cancer ...
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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
... Particularly, miRNA-122, miRNA-30a, and miRNA-192 showed the most substan- tial increases and revealed an excellent diagnostic value for differentiating alcohol-fed mice versus pair-fed ...of ...
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Intratumoral heterogeneity of microRNA expression in rectal cancer
... Interestingly, we found a poor correlation between the results from RT-qPCR and ISH for all the miRNAs; so even though ICC (single and mean) is equal for RT-PCR and ISH for miRNA-21, the results are not ...
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Original Article Multicentric papillary thyroid carcinoma: a clinical analysis of 221 patients
... As shown in Table 1, the incidence of multic- entric papillary thyroid carcinoma was 21.7% (221/1017). The median age was 44 (7-105) years; 84 patients were male, and 137 patients were female (male:female ratio, ...
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Original Article Correlation research on plasma miRNA-17-5p and miRNA-20a with prognosis for pulmonary arterial hypertension
... Abnormal miRNA expression may be the patho- genesis of a variety of diseases, including ...concerning miRNA-BMPR2 signal pathways ha- ve suggested that IL-6 mediates STAT3 activa- tion and induces ...
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Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1
... Notch signalling is a highly conserved cell signalling pathway that is involved in the regulation of diverse fundamental cellular processes, such as proliferation, stem cell maintenance, and differentiation [16]. Notch ...
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Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells
... and there was no impact on JAM-A mRNA detectable, suggesting that the miRNA was degraded in the medium and/or unable to cross the plasma membrane, perhaps reflecting the mutual negative charges. The transfection ...
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MicroRNA Detection Using a Double Molecular Beacon Approach: Distinguishing Between miRNA and Pre-miRNA
... in miRNA processing, a single miRNA genomic locus can generate multiple mature miRNAs that differ by only a few nucleotides; these variants are known as isomiRs (miRNA ...the miRNA seed ...
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