Mismatch repair proteins
Original Article Expression status of four mismatch repair proteins in patients with colorectal cancer: clinical significance in 1238 cases
... of mismatch repair proteins (MMR) in colorectal cancer (CRC) and to ana- lyze the correlation between MMR and pathologic features of CRC, immunohistochemistry was used to detect the expression of ...
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... the repair of DNA replication errors and the maintenance of genomic stability (20, ...MMR proteins play key roles in nonrepair mechanisms as well ...MMR proteins play an as-yet-undefined role in ...
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Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.
... The strong homology of MSHl and ,MSH2 to the procaryotic MutS homo- logs known to function in mismatch repair suggests that the yeast homologs are involved in mismatc[r] ...
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An Escherichia coli Effector Protein Promotes Host Mutation via Depletion of DNA Mismatch Repair Proteins
... ABSTRACT Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E. coli depletes ...
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Distinct Roles for the Saccharomyces cerevisiae Mismatch Repair Proteins in Heteroduplex Rejection, Mismatch Repair and Nonhomologous Tail Removal
... 2003 In vitro and in vivo studies of MutS, MutL and MutH Spell, R. M., and S. Jinks-Robertson, 2004 Examination of the roles mutants: correlation of mismatch repair and DNA recombina- of Sgs1 and Srs2 ...
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Role of DNA Mismatch Repair and Double-Strand Break Repair in Genome Stability and Antifungal Drug Resistance in Candida albicans
... DNA repair pathways are eliminated, we constructed yeast strains bearing deletions in six genes involved in mismatch repair (MSH2 and PMS1) or double-strand break repair (MRE11, RAD50, RAD52, ...
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DNA repair in the archaea – an emerging picture
... DNA repair genes across the archaea add to this hot topic (Figure 2)? If we take the example of the XPF nuclease, it comes in two “flavours” in ...eukaryal-type repair proteins one would expect for ...
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Antagonism of Ultraviolet-Light Mutagenesis by the Methyl-Directed Mismatch-Repair System of Escherichia coli
... excision repair in mut 1 nisms, but rather by insertion during DNA replication of bacteria, or faster replication (relative to repair) in mut 2 adenines opposite photoproducts containing cytosines ...by ...
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Heterogenous mismatch-repair status in colorectal cancer
... the mismatch repair proteins MLH1, PMS2, MSH2 and MSH6 were identified in 14 colorectal ...retained/lost mismatch repair protein expression could be classified as intraglandular (within ...
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Low frequency of mismatch repair deficiency in gallbladder cancer
... DNA mismatch repair deficiency-induced alterations at long mononucleotide re- peats [7, ...DNA mismatch repair proteins MLH1, PMS2, MSH2, and MSH6 revealed no loss of nuclear ...
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Maternal Effect for DNA Mismatch Repair in the Mouse
... female germ line was ⵑ9%. MSI was also observed in paternal alleles, a surprising result since the alleles were obtained from wild-type males and the embryos were therefore DMR proficient. We propose that mosaicism for ...
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<p>Evaluation of Concordance Between Deficient Mismatch Repair and Microsatellite Instability Testing and Their Association with Clinicopathological Features in Colorectal Cancer</p>
... interpretation of IHC results. Abdel-Rahman et al also reported that CRC patients with MSH6 mutations did not demonstrate MSI-H by PCR-CE because of a functional redundancy in the MMR system but demonstrated loss of MSH6 ...
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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... DNA mismatch-repair system can protect cells against this mutagenic ...in mismatch-repair-defective mutH, mutL, and mutS strains than in a wild-type ...the mismatch-repair system ...
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The archaeal RecJ like proteins : nucleases and ex nucleases with diverse roles in replication and repair
... recombinant proteins has confirmed that both TaRecJ1 and TaRecJ2 are exonucleases, but with different substrate preferences and different polarities: TaRecJ1 possesses 5’→3’ ssDNA-specific exonuclease activity ...
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A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae
... DNA mismatch recognition complex and the Sgs1 helicase act to suppress SSA between divergent sequences by binding to mismatches present in heteroduplex DNA intermediates and triggering a DNA unwinding mechanism ...
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Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population
... assessed. Mismatch repair (MMR) proteins (MSH2, MSH6, PMS1, and MLH1) expression was detected by immunohistochemistry using tumor tissues of all ...MMR proteins intact (MMR-I) ...
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Deficient mismatch repair: Read all about it (Review)
... and endometrioid histologies (p<0.007) (107). Another study finding no association between MSI and survival was carried out on a series of Danish patients by Begum et al, who used a panel of 16 dinucleotide markers ...
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Evolutionary consequences of DNA mismatch inhibited repair opportunity.
... T h e natural selection attributable to the interaction between mismatch in- hibited repair opportunities associated with nucleotide sequence heterozygosity and increased le[r] ...
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Functional Overlap in Mismatch Repair by Human MSH3 and MSH6
... DNA mismatch repair by intro- cho, 1995 Genomic instability in repeated sequences is an early ducing chromosome 2 into human tumor cells with mutations somatic event in colorectal tumorigenesis that ...
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Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis
... MBD4 proteins were performed as previously described [46, ...mutant proteins on the intrinsic rate of thymine and uracil removal compared with wild-type enzyme, glycosylase assays were carried out under ...
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