Mitochondrial apoptotic pathway
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation
... ABSTRACT We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53- independent apoptosis in a wide range of tumor cell ...
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PNS-R1 inhibits Dex-induced bronchial epithelial cells apoptosis in asthma through mitochondrial apoptotic pathway
... of mitochondrial apoptotic pathway in the asthmatic mice treated with Dex Mitochondrial pathway is an important way to induce apoptosis, which includes Bcl-2, Bax, Cyt-c, Apaf-1 and ...
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Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis
... the mitochondrial apoptotic pathway, would protect against motor neuron ...the mitochondrial apoptotic pathway early in the disease process and that apoptotic signaling ...
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Original Article Tumstatin peptide 19 can induce Hep-2 cell apoptosis through the mitochondrial apoptotic pathway
... In summary, our study demonstrated that tum- statin peptide 19 can significantly inhibit the proliferation of Hep-2 cells in adose-dependent manner. Further investigation revealed that the tumstatin peptide 19-mediated ...
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Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway
... the mitochondrial apoptosis in prostate cancer ...the mitochondrial apoptotic pathway mediated through the enhanced expression of the pro-apoptotic Bax and inhibition of Bcl-2, ...
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Brucea Javanica Leaf Extract Activates Caspase-9 and Caspase-3 of Mitochondrial Apoptotic Pathway in Human Oral Squamous Cell Carcinoma
... Higher-density bands of cleaved-Caspase-9 and cleaved- Caspase-3 were observed in HSC-2 and HSC-3 cells treated with 500 μg/mL BJLE than 100 μg/mL BJLE. CONCLUSION: BJLE could induce apoptosis by activation of Caspase 9 ...
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Original Article Effects of Buyang Huanwu decoction combined with edaravone on mitochondrial apoptotic pathway of nerve cells in mice with cerebral ischemia-reperfusion injury
... Mitochondrial apoptotic pathway is one impor- tant pathway triggered by brain ischemia, which leads to changes of mitochondrial ...4]. Mitochondrial apoptosis is mainly regulated ...
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Original Article MicroRNA-34a inhibits proliferation and stimulates apoptosis in human keratinocyte through activation of Smac-mediated mitochondrial apoptotic pathway: a potential therapeutic target for psoriasis
... apoptosis, mitochondrial apoptotic pathway Introduction Psoriasis is a common chronic inflammatory skin disease affecting about 2% to 3% of the European ...
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BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway
... this mitochondrial enzyme resulted in anemia at larval ...apoptotic pathway. Moreover, BCDO2 prevented this induction of the apoptotic pathway by ...as mitochondrial carotenoid ...
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Investigation of the caspase dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus
... During disease flare-up, CD19+ cells are prone to produ- cing more autoantibodies with mitochondrial activation, which may lead to APO2.7-related apoptosis. However, the detailed apoptosis mechanism remains ...
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Original Article Fangchinoline induces cell apoptosis via the mitochondrial apoptotic pathway in gastric cancer cells
... the apoptotic can- cer cells were significantly in- creased in a concentration- dependent manner after the incubation of FCL in both HGC- 27 and SGC-7901 cells (Figure 2A, ...
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ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients
... and Bcl-w anti-apoptotic proteins for the benefit of Bad/ Bcl-2, Bad/Bcl-xl, and Bad/Bcl-w interactions in a context of low expression of Bcl-xl and Bcl-w and of non- phosphorylation of Bad. Thus, these results ...
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PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins
... Small interfering RNA against Apaf-1, caspase-9, caspase-8, Smac, Bax, Bak, and Bid and the control non-silencing siRNA duplex that does not target any sequence in the genome were purchased from QIAGEN. Cells were ...
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Original Article Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway
... TUNEL We prepared several 5-µm-thick transverse fro- zen sections of spinal cord tissue and detected apoptotic cells using TUNEL Apoptosis Assay Kit (Roche Diagnostics, Germany). Quantitation was performed by ...
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Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway
... induce apoptotic death in cancer cells through the mitochondrial pathway [31, 32]; however, whether DDA causes cell death via this pathway is still ...the mitochondrial pathway ...
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Role of the Mitochondrial Signaling Pathway in Murine Coronavirus-Induced Oligodendrocyte Apoptosis
... the mitochondrial pathway in MHV-induced oligodendrocyte ...the mitochondrial apoptotic ...the mitochondrial pathway is partially responsible for the ...
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Bax Is Activated during Rotavirus-Induced Apoptosis through the Mitochondrial Pathway
... Rotaviruses are the leading cause of infantile viral gastroenteritis worldwide. Mature enterocytes of the small intestine infected by rotavirus undergo apoptosis, and their replacement by less differentiated dividing ...
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Porcine parvovirus infection activates mitochondria mediated apoptotic signaling pathway by inducing ROS accumulation
... Methods: To determine the effects of PPV infection on the apoptosis, we detected morphological changes, DNA ladder, activities of caspases, and expression of PARP in PPV-infected ST cells. Moreover, aiming to investigate ...
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The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat
... of mitochondrial membranes and the subsequent liberation of pro-apoptotic factors such as cy- tochrome C (Tsujimoto, Shimizu, Narita, & Tsujimoto, ...
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The Major Apoptotic Pathway Activated and Suppressed by Poliovirus
... the pathway resulting in the apoptotic death of po- liovirus-infected cells and to map the step of this pathway that is suppressed by the viral antiapoptotic ...specific apoptotic pathways, we ...
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