Mitochondrial calcium
Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies
... SC mitochondrial anom- alies and improve the phenotype of diabetic ...(A) Mitochondrial calcium, (B) cytoplasmic calcium, (C) mitochondrial pH, and (D) motility in mSCs of diabetic mice ...
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Inhibition of mitochondrial calcium uptake 1 in Drosophila neurons.
... alters mitochondrial calcium signaling and results in the proximal skeletal muscle weakness and brain disorder (Logan et ...in calcium signaling and possibly in mitochondrial calcium ...
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EMRE is essential for mitochondrial calcium uniporter activity in a mouse model
... Z-stacks. Mitochondrial calcium was quantified relative to the mitochondrial content (Rhod-2/MitoTracker Green) per ...a mitochondrial mask, and mitochondrial calcium to content ...
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The Hepatitis B Virus X Protein Elevates Cytosolic Calcium Signals by Modulating Mitochondrial Calcium Uptake
... was calcium dependent and stimulated HBV replication (33, ...intracellular calcium signaling are incompletely under- ...extracellular calcium into HepG2 cells ...cytosolic calcium signals ...
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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
... Fig. 3 Neuronal rescue of NCLX expression impedes cognitive decline and AD pathology. a Schematic of tetracycline-responsive (TRE) transgenic construct and neuronal-speci fi c driver, Camk2a-tTA. Neuronal-speci fi c ...
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Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
... a mitochondrial calcium uniporter (TcMCU) with characteris- tics similar to that of mammalian mitochondria was fundamental for the discovery of the molecular nature of MCU in ...in mitochondrial Ca ...
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The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle
... augment mitochondrial fatty acid and glucose oxidation, yet glycolysis and lactate production, which are major aspects of anaerobic sprinting, still provide much of the ...
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The Mitochondrial Calcium Uniporter Is Autoregulated by Cation Binding to the β-Grasp-Like Matrix Domain
... (MCU), as a universally expressed protein that is present in mitochondria, with two TM domains that oligomerizes to form a larger complex (Baughman et al., 2011; De Stefani et al., 2011). In order to identify proteins ...
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Acetate transiently inhibits myocardial contraction by increasing mitochondrial calcium uptake
... The acetate-induced stimulation of mitochondrial Ca 2+ uptake appears to be the seminal event leading to re- duced inotropy. However, in the sustained presence of acetate, fractional shortening recovers to control ...
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Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function
... increased mitochondrial superoxide significantly in cardiomyocytes, as indicated by MitoSOX Red fluorescence, which is a mitochondrial superoxide indicator (Figure ...the mitochondrial inner membrane ...
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Studies on the movement of calcium across the inner Mitochondrial membrane
... CHAPTER 5 PROTONMOTIVE FORCE AND MITOCHONDRIAL CALCIUM TRANSPORT CHAPTER 6 Introduction 80 Results 84 Discussion 93 THE INFLUENCE OF THE PROTON CONCENTRATION ON CALCIUM-ION FLUXES ACROSS[r] ...
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Expression of MICU1 after experimental focal cerebral ischemia in adult rats
... Background: Mitochondrial Ca 2+ uptake is a pivotal pathophysiological process for neuronal survival when subjected to ischemic ...insult. Mitochondrial calcium uptake 1 (MICU1) has been demonstrated ...
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The spatial and temporal relationship between oxidative stress and neuronal degeneration in 3 nitropropionic acid model
... of calcium results in a significant increase in the production of free radical species in the mitochondria of older ...in mitochondrial calcium ...
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Search | Preprints
... mitochondria calcium signaling results in enhanced oxidative phosphorylation and this could result in a concomitant increase in ROS ...ER-mitochondrial calcium signaling reduces the levels of ROS ...
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CURRICULUM VITAE Elena N. Dedkova, D.V.M., Ph.D.
... 7. Seidlmayer L., Blatter L.A., Dedkova E.N. Increased activity of mitochondrial complex II in rabbit heart failure is associated with reactive oxygen species generation and impaired excitation-contraction ...
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Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes
... The calcium load of mitochon dria is accompanied by massive swelling of these organelles, due to opening of the mitochondrial permeability transition pore (MPTP) in the inner membrane ...
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Systemic isradipine treatment diminishes calcium dependent mitochondrial oxidant stress
... stimulating mitochondrial intermediary metab- olism and oxidative phosphorylation in a manner similar to that found in muscle ...of mitochondrial reactive oxygen species (ROS) and reactive nitrogen species ...
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Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice
... Astrocytes are characteristic star-shaped glial cells responsible for nutritional support, blood-brain barrier formation, extracellular ion balance, and synaptic remodeling [11, 12]. Previous research showed that ...
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Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide
... [10]. Mitochondrial oxygen consumption was determined using a Clark-type electrode (Yellow Springs Instruments Co, Yellow Springs, OH) as previously described ...
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Examination of mitochondrial and cellular response to metabolic stresses: changes in mitochondrial membrane potential by modulators of ischaemic preconditioning and metabolic stress-induced extracellular nucleotide accumulation
... Claycomb et al. have developed a new cell line, HL-1, isolated from the existing AT-1 CM line. These cells are a hybrid of embryonic and adult CM’s, exhibiting CM morphology with a single central nucleus, contractile ...
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