Mitochondrial Complex I
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
... that mitochondrial complex I might be ...cell complex I activity can affect autophagy, we analyzed the effects of Ndi1 expression on p62, a ubiquitin-binding scaffolding protein that is ...
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ANTIBODY TO MITOCHONDRIAL COMPLEX-I IN SOME PATIENTS WITH MULTIPLE SCLEROSIS
... for Complex V the arginine which is mutated to' histidine in Leber's Hereditary Optic Neu ropathy (MTND4*LHONII778A)9 and a major epitope for the induction of antibodies in ...
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Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls
... the mitochondrial ATP synthase and respir- ation, thus affecting state 4 ...functional mitochondrial respiratory chain CI during glutamate/ malate oxidation in the control cell line expressing AtNDA2 ...of ...
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Congenital deficiency of two polypeptide subunits of the iron protein fragment of mitochondrial complex I
... of complex I activity (measured as NADH-ferricyanide reductase) were distinctly altered in the mitochondria from the patient's ...against complex I immunoprecipitated NADH- ferricyanide ...
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Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
... chondrial complex I, on mitochondrial function and anti- tumor ...plex I inhibition induced melanoma cell death in vitro and reduced melanoma tumor growth in various mouse models in ...
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NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency
... as complex IV deficiency (17) suggests that defects may be more likely in genes involved in expression of mtDNA-encoded subunits or in processing and assembly of subunits into the mature ...plex I is not ...
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Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
... plexes I and III (3). Since there are probably two sites within complex I and at least one in complex III where this could happen (3, 16) it is not surprising that excessive superoxide ...
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Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts
... with complex I deficiency (5, 12, 48). In complex I, the 10-, 24-, and 51-kDa subunits closely interact to con- stitute the flavoprotein (FP) fraction of the ...known complex I ...
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Interspecific variation in brain mitochondrial complex I and II capacity and ROS emission in marine sculpins
... complexes I and II in brain mitochondria, with the more hypoxia-tolerant species showing lower complex I and higher complex II flux capacity compared with less-tolerant ...lower complex ...
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Enigmatic Presence of Mitochondrial Complex I in Trypanosoma brucei Bloodstream Forms
... Although there is now evidence for the presence of cI-like sub- complexes in two life-cycle stages of T. brucei, cI functions in the parasite remain enigmatic. In Plasmodium and Saccharomyces cerevisiae, the absence of ...
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A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy
... with complex I assembly defects have been assigned to several different genetic complementation groups ...other complex I assembly genes, but it does have its ...plex I assembly factor ...
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PubMedCentral-PMC5090250.pdf
... level, mitochondrial routine respiration, and hyperpolarization level of the mitochondrial membrane potential, three key indexes for evaluating mitochondrial function, were improved with metformin ...
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Effects of TAT-conjugated platinum nanoparticles on lifespan of mitochondrial electron transport complex I-deficient <em>Caenorhabditis elegans</em>, <em>nuo-1</em>
... of mitochondrial electron transport complex ...this complex I-like activity functions in vivo, we studied the effects of Pt-nps on the lifespan of a mitochondrial complex ...
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Reduction of apoptosis and preservation of mitochondrial integrity under ischemia/reperfusion injury is mediated by estrogen receptor β
... before I/R to pre-treatment with E2 or a specific ER β agonist (ER β ...increased mitochondrial levels of anti-apoptotic Bcl2 and ...of mitochondrial translocase inner membrane (TIM23) and ...
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Year in review 2006: Critical Care – multiple organ failure, sepsis, and shock
... and mitochondrial dysfunction is reported to be one of the key mechanisms ...depressed mitochondrial respiration in endothelial cells and decreased cellular ATP levels ...the mitochondrial ...
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Tamoxifen Mediated Metabolic Stress: Molecular Mechanism and Therapeutic Opportunities
... Tamoxifen is the most widely used adjuvant chemotherapeutic for the treatment of estrogen receptor (ER) positive breast cancer, yet a large body of clinical and preclinical data indicates that tamoxifen can modulate ...
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Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase
... isolated complex I, but only four of them inhibit respiration in cells and ...inhibit complex I activate AMP kinase, strengthening links between complex I and the downstream ...
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The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer
... inhibit mitochondrial complex ...on mitochondrial function, the control and shTPD54 stable knockdown cells were treated with two other complex I inhibitors (piericidin A or rotenone) ...
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Mitochondrial gene translation products in the mitochondrial myopathies
... Histological studies can be performed on frozen cross sections of a small muscle biopsy obtained under local anaesthetic from usually, the triceps, quadriceps or vastas lateralis muscle. The modified Gomori trichrome ...
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Diffusion Tensor Imaging Mapping of Brain White Matter Pathology in Mitochondrial Optic Neuropathies
... on mitochondrial diseases in the Italian region Emilia Romagna; OTHER RELATION- SHIPS: currently involved in clinical trials with EPI-743 (␣-tocotrienol quinone) in Leber hereditary optic neuropathy (Edison ...
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