Mitochondrial complex I inhibition
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
... Complex I inhibition using BAY 87-2243 reduces ATP levels and induces an energy crisis in melanoma cells To further address the mechanism behind the BAY 87- 2243-induced anti-tumorigenic phenotype, ...
16
Decylubiquinone increases mitochondrial function in synaptosomes
... chain complex activities with aging. The activity of complex I has been reported as being lower in aged rat brain mitochondria (35), complex I/III activity was reduced by 48% in brain ...
8
Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain
... PGZ-induced complex I inhibition might lead to an increased tran- scription of some components of the ...regulating mitochondrial biogenesis in mice and that this effect was associated with an ...
15
Mitochondrial plasticity in the cerebellum of two anoxia tolerant sharks: contrasting responses to anoxia/re oxygenation
... i.e. mitochondrial complex II or CII) and the partial inhibition of the malate/aspartate shuttle (Chouchani et ...at complex I (CI) (discussed in Andrienko et ...
11
Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung
... decreased Complex I and III activity in the tissues of these patients (liver tissue upon liver transplantation, skeletal muscle and skin fibroblasts obtained through ...of Complex III activity is a ...
13
Maize Dek37 Encodes a P-type PPR Protein That Affects cis-Splicing of Mitochondrial nad2 Intron 1 and Seed Development
... Complex I is the primary entry point for electrons into the electron transport chain, inhibition of which by inhibitors or by loss of subunits leads to problems with primary metabolism in the ...
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Therapeutic concentrations of antidepressants inhibit pancreatic beta cell function via mitochondrial complex inhibition
... Complexes I and III, and also impaired the ability of MIN6 cells to reduce MTT and produce ATP, we investigated whether the drugs could affect glycolysis via measurement of their lactate output as well as generate ...
43
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
... of complex I activity through Ndi1 did not alter tumor cell proliferation in vitro, but clearly reduced tumor growth and metastasis in ...through complex I may become ...of complex ...
15
Succinate and the shortcut to the cure of metformin-induced lactic acidosis
... chain complex I plays a key role in the pathogenesis of metformin-induced lactic ...vitro mitochondrial oxygen consumption coupled with energy production and decreased lactate production in intact ...
6
Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
... (after inhibition of mitochondrial chain complex V F0-ATP synthase with oligomycin), was not different among treatments ...over mitochondrial respiration for ATP ...whether ...
14
PubMedCentral-PMC5090250.pdf
... platelet mitochondrial ROS production (Supplementary ...the mitochondrial membrane potential ...and mitochondrial routine respiration ...via inhibition of complex ...
12
Tamoxifen Mediated Metabolic Stress: Molecular Mechanism and Therapeutic Opportunities
... via inhibition of mitochondrial complex I, resulting in an increase in the AMP/ATP ratio and activation of the AMPK signaling pathway in vitro and in ...through inhibition of the mTOR ...
85
ANTIBODY TO MITOCHONDRIAL COMPLEX-I IN SOME PATIENTS WITH MULTIPLE SCLEROSIS
... of Complex 1. They deduced this from a study of the activity of Complex I with rotenone and quinones, in patients with MTND4*LHONl1778A where arginine-340 is replaced by a ...
6
Inhibition of mitochondrial calcium uptake 1 in Drosophila neurons.
... MICU1 is required for MCU-mediated calcium uptake (Perocchi et al., 2010), and plays an essential gatekeeping role to regulate cell survival (Mallilankaraman et al., 2012). The two MICU1 calcium-binding EF-hands are a ...
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Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.
... Four new missense mutations have been identified through restriction analysis and sequencing of the mitochondrial DNAs (mtDNA) from Leber’s hereditary optic neuropathy (LHON) [r] ...
11
Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
... uptake was shown to increase autophagy as a survival mechanism (24, 25). Huang et al. (10) recently showed that knockdown of MCU in T. brucei procyclic forms increased the expression of autophagy markers under starvation ...
16
Congenital deficiency of two polypeptide subunits of the iron protein fragment of mitochondrial complex I
... of complex I activity (measured as NADH-ferricyanide reductase) were distinctly altered in the mitochondria from the patient's ...against complex I immunoprecipitated NADH- ferricyanide ...
6
EFFECT OF ENDOSULPHAN ON LACTIC DEHYDROGENASE ACTIVITIES IN THE VITAL TISSUES OF SWISS ALBINO MICE
... The inhibition of mitochondrial respiration was found to occur in parallel to the inhibition of enzyme activities of the respiratory electron transport chain of mitochondria such as LDH thus the ...
5
Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNAAla mutation in cybrids
... of mitochondrial defect by AARS2 was related more to the enzyme activities than to the stabilizing effect on the mt-tRNA structure in the case of the 5655A>G ...
8
Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls
... A. thaliana NDH-2 naturally coexist with CI: their activity is stimulated when electron flux through mito- chondrial OXPHOS is slowed down, most likely depend- ing on their intrinsic enzymatic properties [15–18, 33]. ...
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