Mitochondrial cytochrome c release
Detarium microcarpum Stem Bark Extracts Induce Apoptosis in Human Breast Adenocarcinoma MDA MB 231 Cells via cJNK Activation and Mitochondrial Cytochrome C Release
... The plant material was collected from Biu town in Northeast Nigeria during the months of May to June. It was identified as D. microcarpum by a plant taxono- mist, and its sample was preserved and documented in the ...
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Protective Role of Apigenin Against Aβ 25-35 Toxicity Via Inhibition of Mitochondrial Cytochrome c Release
... receptors. Mitochondrial synapses dysfunction due to the accumulation of Amyloid Beta (Aβ) is one of the earliest pathological features of ...restoring mitochondrial dysfunction and inhibition of caspase ...
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Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release
... culture plates. After incubation for 24 hours to allow cell attachment, the exponentially growing cells were exposed to NiZn ferrite nanoparticles at concentrations of 10, 50, 100, and 1000 µ g/mL. The plates were then ...
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Release of Mitochondrial Cytochrome C in Both Apoptosis and Necrosis Induced by β-Lapachone in Human Carcinoma Cells
... Conclusions: ,B-lapachone induces either apoptotic or necrotic cell death in a variety of human carci- noma cells including ovary, colon, lung, prostate, and breast, suggesting a wide sp[r] ...
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Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan
... Cyt c release from mitochondria and apop- tosis ...the mitochondrial inner membrane, al- lowing the transmission of a solute with a molecular mass of up to approximately ...with mitochondrial ...
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APOPTOSIS SIGNALING; A DRUG DESIGN IN CANCER THERAPY: A REVIEW
... of cytochrome c release), inhibitor of apoptosis proteins (IAPs) (inhibition of caspases), and second mitochondrial activator of caspases (Smac) and Omi (negative regulation of ...the ...
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Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells
... In apoptotic signaling, there are two caspase-dependent pathways, i.e. extrinsic and intrinsic [5]. The extrinsic pathway is activated in Fas-induced apoptosis. In this pathway, the Fas ligand, a member of the ...
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A Caspase-activated Factor (CAF) Induces Mitochondrial Membrane Depolarization and Cytochrome c Release by a Nonproteolytic Mechanism
... A family of cysteine proteases, termed caspases, plays a central part in both induction and execution of apop- tosis mediated by Fas and the p55 TNF receptor. Caspases are expressed as inactive zymogens and become ...
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Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization
... synthesis, release and uptake (16,20,21), as well as inhibition of protein phos- phorylation ...the mitochondrial and cytosolic forms of aspartate aminotransferase showed moderate competitive bilirubin ...
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IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling
... The release of Cytochrome c from mitochondria to cytoplasm and the translocation of Bax from cytoplasm to mitochondria are required for caspase activation that initiates the apoptotic program ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... by cytochrome c release from mitochondria to the cytosol (8, ...the mitochondrial pathway in neuroblastoma IMR5 ...chrome c release is Bax dependent in these ...
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Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
... cleavage, cytochrome c release, mitochondrial membrane potential, the Bcl-2 and Bcl-XL antiapoptotic proteins, senescence, p65 phosphorylation, and pro- and antiapoptotic ...
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Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate
... including mitochondrial mem- brane potential disruption and cytochrome c release were ...Altered mitochondrial structure, such as condensed mitochon- dria has functional ...
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The effect of amixin and agmatine on cytochrome c release from isolated mitochondria
... Our data suggest that pharmacological effects of amixin and agmatine, beside other activities, may include the influence on mitochondria functioning, in particular, the mitochondrial pathway of apopto- sis. Taking ...
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RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca 2+ /MICU1 dependent mitochondrial signaling
... the release of cytochrome C (Cyto C) from mitochondrial, increased the location of BID on mitochondrial membrane and the cleavage of the pro-apoptotic proteins (PARP, caspase-3 ...
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Predicting effective pro apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling
... elicit mitochondrial outer membrane permeabilisation in response to BCL-2-targeting BAD-BH3 peptide or MCL-1-targeting MS1-BH3 ...rapid cytochrome C release when pladienolide B, torin1, ...
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Therapeutic Modulation of Apoptosis: Targeting the BCL 2 Family at the Interface of the Mitochondrial Membrane
... 1. Mitochondrial membranes are sites of dynamic events during ...outer mitochondrial membrane (OMM), membrane-associated BAX monomers (dark red) are found in close association with anti-apoptotic proteins ...
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Cathepsin B contributes to TNF α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
... promote release of cat B from lyso- somes? Because TNFR-1 appears to initiate apoptotic signaling by activating caspases (11, 15), we sought to determine whether proximal caspases could directly promote ...
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Helicobacter pylori vacuolating toxin A and apoptosis
... the mitochondrial inner membrane, forming chloride ...the mitochondrial membrane potential causes recruitment of Bax and Bak, release of cytochrome c, and ...
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Original Article Ulinastatin inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling
... on mitochondrial function. In normal cells, cytochrome c is located in the mitochondrial intermembrane/intercristae ...mobilize cytochrome c from cardio- lipin leading to the ...
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