Mitochondrial DNA copy Number
Genetic factors modulating mitochondrial DNA copy number
... showing mitochondrial DNA copy number (mtDNA CN) changes (copies/cell) (y-axis) depending on the number of cumulative averged replicates included in the delta Ct calculation (x-axis), ...
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Association of mitochondrial DNA copy number with self-rated health status
... Keywords: mitochondrial DNA copy number, self-rated health, personalized medicine Introduction Patient-reported outcomes and self-rated health are important predictors for many adverse health ...
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Pre-diagnostic leukocyte mitochondrial DNA copy number and risk of lung cancer
... the number of PCR cycles required to detect a signal over background fluorescence and is inversely proportional to the amount of ...the mitochondrial ND2 gene copy number to genomic ...
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Mitochondrial DNA copy number instability in ERBB2-amplified breast cancer tumors
... the mitochondrial DNA copy number relative to the nuclear DNA was carried out by using real-time ...nuclear DNA, were designed using Pri- mer3. Mitochondrial Primer ...
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Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer
... small number of events among localized ...by mitochondrial DNA copy number in peripheral blood leukocytes among localized prostate cancer patients who received active ...
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Changes in peripheral mitochondrial DNA copy number in metformin-treated women with polycystic ovary syndrome: a longitudinal study
... hsCRP − 0.12933 (0.290) − 0.06189 (0.608) 8-OHdG 0.06776 (0.538) – mtDNA-CN – 0.06776 (0.538) Data given as r (p-value); p-value < 0.05 is denoted with *; BMI Body mass index, SHBG Sex hormone binding globulin, FAI Free ...
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Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
... Decreased MtDNAcn in placental tissues has been associ- ated with prenatal PM 10 exposure (mean=22.7 ± 3.7 in whole pregnancy) [25] and maternal smoking [26]. Our additional analysis on male and female have found higher ...
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Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish.
... thereby force the cells to rely more on their mitochondrial dNTP pools and thus on the enzymatic activity of dGK. However, no morphological phenotype was observed in the dguok − / − fish as a consequence of ENT ...
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Differential mitochondrial DNA copy number in three mood states of bipolar disorder
... ng DNA templates in a 10 ul reaction volume and randomly assigned to 96-well ...ND1 copy num- ber to HBB copy number from standard ...calibrator DNA in order to standardize between ...
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The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis
... mtDna copy number as biomarker in presbycusis in the number of mitochondrial genomes in presbycusis subjects, due to mitochondrial dysfunction, may be one of the molecular mechanisms ...
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Elevated mitochondrial DNA copy number in peripheral blood cells is associated with childhood autism
... mtDNA copy num- ber with the risk of autism; and potential population stratifi- cation was not ...mtDNA copy number in peripheral blood cells, brain tissues are considered as the standard target ...
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Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women
... between mitochondrial-mediated oxidative stress-defense mechanisms and weight change may suggest future strategies for weight management via reducing oxidative ...
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Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure
... stimulates mitochondrial proliferation to supply energy to meet the need for cell survival, including damage repair and synthesizing new proteins (Lee and Wei ...in DNA methyl ation can also result from ...
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Vitrification of Mouse MII Oocyte Decreases the Mitochondrial DNA Copy Number, TFAM Gene Expression and Mitochondrial Enzyme Activity
... by mitochondrial respiratory chain and may alter the mtDNA copy number ...mtDNA copy number (22, ...by mitochondrial genome but other subunits of these complexes and total ...
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A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts
... with DNA ex- tracted from both white cells and whole blood: it is pos- sible that combining individuals with DNA prepared from multiple sources could lead to preferential detec- tion of loci associated with ...
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Quantifying mitochondrial DNA copy number using robust regression to interpret real time PCR results
... a copy number 10 times below their un-diluted counter- ...a mitochondrial copy number of 200, corresponds to having a 95% confi- dence interval between 150 and ...the number of ...
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Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution
... mtDNA copy number is quantitative PCR ...of mitochondrial to nuclear DNA; however, qPCR is par- ticularly susceptible to differing PCR efficiencies between target and housekeeping genes, ...
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Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
... mtDNA copy number, DNA meth- ylation and nuclear gene expression at different stages of development highlights the need for cells to establish a balance between these three components to promote ...
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DNA isolation protocol effects on nuclear DNA analysis by microarrays, droplet digital PCR, and whole genome sequencing, and on mitochondrial DNA copy number estimation.
... the DNA isolation protocol, we isolated cerebellar DNA with SC using overnight proteinase K (rather than 2 hours), starting with approximately 25 or 5 mg tissue in parallel ( S3 Table ), and with the ...
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From Normal to Obesity and Back: The Associations between Mitochondrial DNA Copy Number, Gender, and Body Mass Index.
... and mitochondrial activity by activation the AMP-activated protein kinase (AMPK) signaling pathways [ 22 ...mtDNA copy number in all observed patients with T2DM before and after bariatric surgery (r ...
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