Mitochondrial mass
High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant
... maximum mitochondrial capacity and mitochondrial proton leak, compared to their differentiated non-CSC progeny ...high mitochondrial mass were also functionally more stem-like, showing ...
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<p>SSBP1 Upregulation In Colorectal Cancer Regulates Mitochondrial Mass</p>
... In this report, we generated representative proteo- mics pro fi les of three stages of CRC and nearby healthy tissue. Bioinformatics analyses of these pro fi les con- fi rmed that the tumors had signi fi cantly different ...
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Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment
... between mitochondrial mass and chemotherapy resistance in subpopulations of the NSCLC cell line A549: We previously described three subpopulations in the parental cell line A549, ...whether ...
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Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
... of mitochondrial mass in muscle cells and adipocytes to be associated with the stimulation of oxygen ...of mitochondrial biogenesis and energy metabolism by ...utilized mitochondrial ...
8
An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients
... and mitochondrial function in ME/CFS lymphoblasts arises because they respond differently to EBV infection than do control ...of mitochondrial changes we observed is not consistent with the reported effects ...
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Cancer stem cell metabolism
... a mitochondrial ROS inducer such as menadione do not become resistant, suggesting that increasing mitochon- drial ROS levels to non-viable levels might be a better approach to eliminate CSCs ...target ...
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Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
... for mitochondrial mass proportional to cell size, these results indicate a deficit in mHsp70 staining in cells from ob/ob mice relative to that of con- ...dense mitochondrial staining was observed ...
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Mitochondrial DNA content and mass increase in progression from normal to hyperplastic to cancer endometrium
... of mitochondrial mass [16], has been reported in type I endometrial cancer compared to proliferative endometrial control tissues, suggesting an increase in mitochondrial biogen- ...dependent ...
5
Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
... the mitochondrial quality and function, leptin may control the cell bioenergetic efficiency ...brain mitochondrial dysfunction, and further, mice learning impairments [38 – ...to mitochondrial ...
10
Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells
... clarify mitochondrial mass, we used NAO, which measures mitochondrial mass by binding to cardiolipin in all ...drial mass increased in late passage PD-MSCs com- pared with early cells ...
13
Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)
... decreases mitochondrial mass and function in H295R ...the mitochondrial mass. D. Reduction in mitochondrial mass was further evaluated by fluorescence microscopy of ...
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Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells
... and mitochondrial superoxide, suggest- ing mitochondria as a prominent source of ...the mitochondrial mass and mtDNA copy number in Kasumi-1, K562 and HL60 ...the mitochondrial machinery and ...
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Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition
... duced mitochondrial mass in both Aβ-treated SH-SY5Y cells and APP/PS1 ...Reduced mitochondrial mass has already been found in brains from AD patients compared to healthy controls in a mouse ...
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Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes
... by mitochondrial relies on mitochondria content, mitochondrial activity and mitochondrial effi- ciency to synthesize ATP from the oxidation of substrates ...dry mass, FA provide twice as much ...
12
Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage
... in mitochondrial DNA (mtDNA) replication following oxidative DNA damage ( 18–20 ...of mitochondrial dysfunction, leading to more ROS ...of mitochondrial TOP1 (TOP1mt) in mitochondrial gene ...
15
“Mitochondrial remodeling” in coronary heart disease
... for mitochondrial fusion and ...of mitochondrial fusion. Mfn1 and Mfn2 locate in the outer mitochondrial membrane with their GTPase site facing the cytosol to coordinate the fusion process with the ...
12
High muscle mitochondrial volume and aerobic capacity in a small marsupial (Sminthopsis crassicaudata) reveals flexible links between energy use levels in mammals
... Thus, our data for S. crassicaudata provide a wide size range over which marsupials have aerobic capabilities that are essentially similar to those of ‘athletic’ placentals (Fig.1), despite the significantly lower BMR ...
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The point mutations of mitochondrial tRNA threonine and proline in idiopathic repeated pregnancy loss
... The mitochondrial genome is extremely susceptible to damages from continuous exposure to ...from mitochondrial respiratory chain and have been considered to be involved in the increased ratio of point ...
6
Mitochondrial disorders: aetiologies, models systems, and candidate therapies
... demonstrated mitochondrial dysfunction, xenomitochondrial mice exhibited no phenotype, suggest- ing compensatory mechanisms at play ...of mitochondrial depletion can result in cellular damage, ...
10
Mitocans as Novel Agents for Anticancer Therapy: An Overview
... induce mitochondrial mem- brane permeabilization and apoptosis via a CsA-inhibi- table mechanism ...disrupt mitochondrial membranes when it is added to purified mitochondria, although the mechanisms of this ...
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