mitochondrial pathway
JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis
... the mitochondrial pathway, as demonstrated by several lines of ...the mitochondrial apoptotic pathway is demonstrated by the following typical ...
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Mechanisms of Heshouwuyin in regulating apoptosis of testicular cells in aging rats through mitochondrial pathway
... Because Heshouwuyin is composed of many kinds of traditional Chinese medicine, the chemical components of Heshouwuyin are not very clear. According to the predecessors’ research, we found that both of the 2, 3, 5, 4’ ...
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Original Article AAVC-I promotes apoptosis of human oral squamous cell carcinoma through the mitochondrial pathway
... the mitochondrial membrane depolarization were ...disrupt mitochondrial membrane depolar- ization and result in cellular apoptosis, and the apoptosis rate of NH4 increased with the concentration of ...the ...
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Di(2 ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC 2spd cells
... cells. Mitochondrial pathway is an extrinsic program of apoptotic death, which is characterized in this study by the disruption of Bcl-2/Bax balance and the activation of cytochrome c and ...
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Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells
... Purpose: Gastric and colon cancers have been the leading causes of cancer mortality in the world with limited therapy. Small molecules binding to bromodomains of bromodomain-containing protein 4 (BRD4) exert strong ...
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Original Article Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity via inhibiting the mitochondrial pathway of apoptosis
... Abstract: The goal of this experiment was to investigate the protective effect and the molecular mechanism of Panax Notoginseng Saponins (PNS) on cisplatin-induced nephrotoxicity through mitochondrial ...
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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
... In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that promote ...
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Original Article MPTP related mitochondrial pathway in oroxylin A induced-apoptosis in HepG2 cancer cells
... the mitochondrial pathway in cancer ...the mitochondrial pathway in human hepatoma HepG2 ...that mitochondrial permeability transition pore (MPTP) was activated, suggesting the elevated ...
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Synergism between PGC-1α and estrogen in the survival of endometrial cancer cells via the mitochondrial pathway
... the mitochondrial pathway in PGC-1 α deficiency-induced cellular apoptosis in endometrial cancer ...in mitochondrial membrane permeability of Ishikawa cells ...the mitochondrial function to ...
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Bax Is Activated during Rotavirus-Induced Apoptosis through the Mitochondrial Pathway
... apoptotic pathway (1, 15, 35, 44) and have been impli- cated in various models of virus-induced apoptosis (28, ...into mitochondrial membranes (18, ...apoptotic mitochondrial pathway is acti- ...
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Original Article Homoharringtonine enhances idarubicin-induced apoptosis via regulation of the mitochondrial pathway
... Dose-related cellular injury within the cardiac myocytes can be mediated by increased oxida- tive stress. In this study, we also find that IDA but not HHT induced apoptosis by triggering the production of ROS mediated ...
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Swainsonine Induces Apoptosis through Mitochondrial Pathway and Caspase Activation in Goat Trophoblasts
... executioner caspase in apoptosis pathway [27, 28]. To determine which caspase molecules are involved in SW-induced apoptosis, we measured the activities of caspase-8, -9, and -3 in SW-treated GTCs using the ...
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Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway
... the mitochondrial signaling pathway and plays a crucial role in inhibiting neuronal cell death, suggesting that Tat-HSP22 protein may be used to prevent oxidative stress-related brain diseases including ...
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Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage
... the mitochondrial membrane potential (MMP) to reduce the apoptosis of oxygen-glucose deprivation (OGD)-injured PC12 cells, possibly through the regulation of RARα signal- ing [16, ...the pathway to ...
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Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells
... of mitochondrial function has been shown to be a key event in the apoptotic cascade ...outer mitochondrial membrane, which is associated with the collapse of the mitochondrial membrane potential ( Δ ...
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BROMELAIN PLUS PEROXIDASE FROM PINEAPPLE INDUCES APOPTOSIS VIA MITOCHONDRIAL DEPENDENT PATHWAY IN LYMPHOMA CELLS
... ABSTRACT: Bromelain is a protease present in pineapple fruit and stem. It is reported that commercially available pure bromelain has anticancer, anti- inflammatory and other therapeutic effects. But there are few reports ...
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Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS mediated mitochondrial dependent pathway
... the mitochondrial path- way, the death receptor pathway and the endoplasmic reticulum pathway, in which the mitochondrial pathway is the major one ...signaling pathway is ...
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Role of the Mitochondrial Signaling Pathway in Murine Coronavirus-Induced Oligodendrocyte Apoptosis
... the mitochondrial pathway is activated by MHV infection, we further sought to identify the upstream signals that trigger activation of the mitochondrial ...the mitochondrial apoptotic ...
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Investigation of the caspase dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus
... through mitochondrial pathway is different from the virus-related apoptosis and/or activation pathway in SLE ...the mitochondrial pathway may exist but war- rants further ...
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Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway
... In this study, we constructed an mRNA-peptide display library and used total protein from SKBr-3 breast cancer cells as bait to screen for specific antibreast cancer peptides. One of the captured peptides (SA12) ...
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