Mitochondrial superoxide
Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1
... in mitochondrial superoxide anion generation as a transcriptional ...increase mitochondrial superoxide anion and mitochondria membrane potential, which induces G1 phase arrest in colon cancer ...
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Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis associated ovarian cancers
... Mitochondrial superoxide dismutase (SOD2) is an en- zyme that metabolizes superoxide in mitochondria and plays an important role in maintaining mitochondrial function through oxidative stress ...
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Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide
... simulation platform-is its involvement in Rac1-driven networks and effects on mitochondrial redox metabolism [29-32]. To that end, GTP-loaded Rac1 has been shown to directly interact with STAT3 via its effector ...
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Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
... the mitochondrial origin of ROS production, BMCs from FM patients and controls were exposed to MitoSOX™, a red mitochondrial superoxide ...by mitochondrial ROS in BMCs and plasma from FM ...
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Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis
... reduced mitochondrial superoxide dismutase (SOD2), and administration of a SOD2 mimic (MnTBAP) normalized the expression of NHE3, NCC, and the components of AGT/ACE pathway affected by albuminuria, ...
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Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation
... increased mitochondrial superoxide production (Supplement- ary ...with mitochondrial membrane potential decline ...on mitochondrial membrane potential by JC-1 ...in mitochondrial ...
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AMPK dysregulation promotes diabetes related reduction of superoxide and mitochondrial function
... in superoxide production (Figure 2, A and B); however, there was no detectable increase in kidney homogenate from diabetic mice as compared with kidney homogenate from control ...increase superoxide ...
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Inhibition of GAPDH activity by poly(ADP ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
... of superoxide by the mitochon- drial electron transport chain activates the three major pathways of hyperglycemic damage found in aortic endothelial cells by inhibiting GAPDH ...by mitochondrial ...
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WIPI1 is a conserved mediator of right ventricular failure
... Study design. The goal of this study was to identify unique genetic determinants of RVF that might be target- ed for the development of novel RVF-specific therapy. Towards this end, we leveraged transcriptomic data from ...
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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... hyperglycemia-induced mitochondrial superoxide overproduction increases O- linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of ...
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Role of Antioxidant in the Prevention and Treatment of Type 2 Diabetic Retinopathy
... 1) DNA Methylation: In DNA methylation there is addition of a methyl group on 5 position of cytosine residues of the cluster of CpG Island (CpG dinucleotides), which is the regulatory region of most genes & typically ...
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Peculiarities of the free radical processes in rat liver mitochondria under toxic hepatitis on the background of alimentary protein deficiency
... of superoxide anion radical, hydroxyl radical and hydrogen peroxide generation, the level of oxidative modification of mitochondrial proteins in the liver of rats with toxic hepatitis was investigated on ...
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Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress
... [11]. Mitochondrial dysfunction observed in Parkinsonism or ESRD, may lead to high cellular oxygen tension since dysfunctional mitochondria consume little ...
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Superoxide in skeletal muscle: sites that regulate intracellular changes during contractions and role in age related degeneration
... thought to be less than 10 seconds (Chiueh, 1999; Moncada et al., 1991). Although it reacts rapidly with many radicals, NO is generally unreactive and does not react rapidly with most biomolecules (Radak, 2000). NO ...
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The protective role of manganese superoxide dismutase against adriamycin induced acute cardiac toxicity in transgenic mice
... manganese superoxide dismutase (MnSOD), a mito- chondrial enzyme, as an animal model to investigate the role of ADR-mediated free radical generation in mitochon- ...marked mitochondrial damage in ...
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Catechin prevents the calcium oxalate monohydrate induced renal calcium crystallization in NRK 52E cells and the ethylene glycol induced renal stone formation in rat
... Renal tubular cell injury is induced by the oxidative stress, which is produced during the attachment of crys- tals to renal tubular cells [10]. Exposure to high con- centrations of oxalate can give rise to the ...
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Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis
... Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was utilized to measure the expression of circ_0008035 and miR-599. 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay was ...
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Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis
... Increased oxidative stress is believed to be an initial and important step in the development of cardiac dysfunction and cardiomyopathy. NADPH oxidase and mitochondria are considered to be important sources of ROS ...
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Journal of Applied Pharmaceutical Science
... induce superoxide generation by mitochondria was estimated using cell-permeable, mitochondria targeted MitoSOX Red probe (Life Technologies) and Hoechst 33342 for nuclear staining (Life ...
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Manganese Induced Toxic Effects on Oxidative System and mRNA Expression of Mn-Sod and Gpx in Albino Rat Brain: Protective Effect of Alpha-Tocopherol
... Manganese is an essential trace element for human and it is an integral part of a series of metalloproteinases such as hydrolases, kinases, decarboxylases and transferases. It is a co-factor of a series of enzymes which ...
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