Mitotic arrest
The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines
... by mitotic arrest, we performed immun- ofluorescence staining for phosphorylated histone H3 (H3P), which is a well characterized mitotic ...in mitotic index was found predominantly in the ...
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Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest
... prolonged mitotic arrest of certain mammalian cell lines by microtubule drugs, Bub1 and BubR1 are degraded by caspases thus inducing exit from M phase without mitosis (17, ...the mitotic spindle ...
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Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells
... that mitotic arrest of PGC proliferation in the genital ridges of BD-WC hybrids occurring before the dimorphic sex differentiation stages (20–30 dph) was the major factor behind the appear- ance of germ ...
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A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin
... overcome this problem and ameliorate metabolism, dif- ferent modifications have been introduced in the stilbene scaffold. As an example, methoxy derivatives, where two or three RSV hydroxyl groups are substituted with ...
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Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified
... arrest, but there may be other pathways. In this regard, the role of Mcl-1 ubiquitination in the regulation of Mcl-1 expression and degradation is instructive. Using a mutant lacking the lysine residues required ...
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Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe
... of mitotic arrest as an in- dication that mutations in the HDACs or loss of function of msc1 allows kinetochore-microtubule interactions to occur that silence the mitotic checkpoint and allow ...
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checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... in mitotic cells. During the incubation for recovery, a mitotic delay and initiation of an abnormal interphase without cytokinesis were ...the mitotic DNA damage response in p53/p21 negative ...after ...
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The Short Life Span of Saccharomyces cerevisiae sgs1 and srs2 Mutants Is a Composite of Normal Aging Processes and Mitotic Arrest Due to Defective Recombination
... This mitotic cell cycle arrest is age independent and requires the RAD9-dependent DNA damage ...G2/M arrest. This arrest can be suppressed by mutations in RAD51, RAD52, and RAD57, suggesting ...
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The zinc finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells
... Absence of mitosis and meiosis are distinguishing properties of male germ cells during late fetal and early neonatal periods. Repressors of male germ cell meiosis have been identified, but mitotic repressors are ...
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Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis
... the mitotic spindle [2]. After G2/M arrest, a significant subpopula- tion of pRb-negative cells demonstrated an excessive amount of 4 N DNA, known as endoreduplication ...
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A Transgene-Induced Mitotic Arrest Mutation in the Mouse Allelic With Oligosyndactylism
... It is not known if sister chromatid separa- tion in these mutant cells occurred at its normal time (and is thus unaffected by the mutation) or was delayed as a result of [r] ...
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Human Parvovirus B19 Induces Cell Cycle Arrest at G2 Phase with Accumulation of Mitotic Cyclins
... arrest. Mitotic arrest is known to be caused by a deficiency in degradation of either cyclin B1 or cyclin A, which is accompa- nied by constitutive activation of MPF (8, ...the mitotic ...
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Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved
... mitotic arrest in BEAS-2B cells after 20 h of exposure which later resulted in mitotic cell death [21]. Here we investigated the in vitro effects of a PM-dose which is among the lowest reported in ...
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CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism
... ine-induced apoptosis and mitotic arrest by flow cy- tometry. Consistent with the immunofluorescence results, annexin V/PI staining-based flow cytometry showed that CYLD and its C/S mutant, but not its ΔCG1 ...
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Inhibition of Bcl xL sensitizes cells to mitotic blockers, but not mitotic drivers
... following mitotic exit ...whereby mitotic Aurora B kinase activity displaces TRF2 from telomeres, giving rise to an exposed telomere that is recognized by DNA damage response path- ways ...suppresses ...
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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
... of mitotic arrest in Usp44-null MEFs compared with controls, consistent with a reinforcing role in the mitotic check- point (Figure ...checkpoint arrest lasting hours. Certain defects in the ...
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Weekly AUC2 carboplatin in acquired platinum resistant ovarian cancer with or without oral phenoxodiol, a sensitizer of platinum cytotoxicity: the phase Ill OVATURE multicenter randomized study
... reduction in sphingosine-1-phosphate leading to AKT inhibition.9-12 Two well described biological effects of PXD are mitotic arrest of tumour cells in the G1 phase of the cell cycle as a[r] ...
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Analysis of mitosis and anti-mitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics
... of mitotic arrest in tumors is consistent with a slower proliferation rate, but because the peak mitotic arrest occurred at 24h in both cases, the cell cycle transit time for cells that commit ...
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Telomere Loss in Somatic Cells of Drosophila Causes Cell Cycle Arrest and Apoptosis
... the mitotic cell cycle are necessary to maintain the fidelity of chromosome ...experience mitotic arrest and then undergo apoptosis when cells are induced to divide as the eye ...
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Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
... metaphase arrest (Figure 2; Supplementary Video ...in mitotic arrest and apoptosis ...induced mitotic arrest after metaphase plate formation (Supplementary Video ...of mitotic ...
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