MKN-45 cell
Original Article Therapeutic efficacy of Xiaotan Sanjie Formula on microsatellite instability of human gastric cancer MKN-45 cells and exploration of the underlying mechanism
... cancer MKN-45 cells in a time-dependent ...cancer MKN-45 cells (D2S123 and D5S346), and sta- bilize the unstable microsatellite loci, most probably by increasing the expression of mis- matched ...
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<p>MiR-203 acts as a radiosensitizer of gastric cancer cells by directly targeting ZEB1</p>
... in MKN-45 cells transfected with ZEB1 and was evidently reduced in AGS cells transfected with shZEB1 compared with that in their corresponding controls (Figure 5A and ...radiosensitivity, ...
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Original Article Elevated JMJD1A is a novel predictor for prognosis and a potential therapeutic target for gastric cancer
... in MKN-45 ...inhibited cell proliferation ...cancer cell proliferation, western blot analysis of the key molecular factors of MAPK pathways were ...the cell proliferation of gallbladder ...
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PLK1 as a potential prognostic marker of gastric cancer through MEK-ERK pathway on PDTX models
... and MKN-45 cells by Western blotting, and significantly inhibited by PLK1 inhibi- tor BI6727, providing a suitable comparison to analyze the role and mechanisms of PLK1 in ...
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<p>Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis</p>
... HMGA1 dysregulation has been con fi rmed to be asso- ciated with a drug-resistant phenotype. 38,39 To explore whether the packaging of HOTTIP into exosomes was mediated by HMGA1, MGC-803 and MKN-45 cells ...
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Original Article Up-regulation of Bromodomain 4 promotes cell proliferation and predicts poor prognosis in gastric cancer
... well-differentiated MKN-28 cells or poor-differenitated MKN-45 cells, we found that BRD4 could act as a promotor of GC cell proliferation and cell apoptosis ...
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Original Article ADAM8 promotes gastric cancer cell invasiveness via EGFR/ERK signaling pathway to upregulate matrix metalloproteinases 2 and 9 expression
... In this study, The ADAM8 mRNA levels were found to be significantly higher in the primary GC tissues compared with the adjacent non- tumor tissues (P<0.001). Moreover, It has been shown that the expressions of ADAM8 ...
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Recombinant immunotoxin anti-c-Met/PE38KDEL inhibits proliferation and promotes apoptosis of gastric cancer cells
... SGC7901 was derived from moderately differentiated GC, with a high metastatic potential [23]. MKN-45 was derived from poorly differentiated GC with low meta- static potential [24]. We found that SGC7901 ...
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MFAP2 promotes epithelial–mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway
... markers in MFAP2-knockdown BGC823 and MKN-45 cells. Interestingly, the Western blotting analysis showed that the expression of MFAP2 was not significantly changed after TGF- β 1 treatment (Figure 5B). ...
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CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest
... cancer cell proliferation, apoptosis and cell cycle using colony formation assay and flow cytometry ...cancer cell line MKN-45 and SGC7901, CMPD1 also induced mas- sive apoptosis and ...
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Downregulation and DNA methylation of ECRG4 in gastric cancer
... Background: Esophageal cancer-related gene 4 (ECRG4) is a novel candidate tumor suppressor gene. Our study investigated the expression and function of ECRG4 in gastric cancer and high- lighted the role of DNA ...
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A positive feedback loop consisting of C12orf59/NF-κB/CDH11 promotes gastric cancer invasion and metastasis
... GC cell lines and ...Renal cell carcinoma that is correlated with increased aggressive tumor behavior and predicts poor survival outcomes of patients, sug- gesting a potential tumor-suppresive role of ...
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Original Article Side population were reduced by Nitidine chloride through suppressing STAT3/c-myc signaling via miR-17-5p in gastric cancer
... cells MKN-45 and OCUM-2MD3, and mechanism of it, specially, to find which proteins and miRs were involved in this ...Methods: MKN-45 and OCUM-2MD3 cells were treated with varying ...
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<p>High expression of SMARCE1 predicts poor prognosis and promotes cell growth and metastasis in gastric cancer</p>
... demonstrated enhanced colony growth in GC cells with high SMARCE1 expression versus those with low SMARCE1 expression (Figures 4B and S1D). Furthermore, we examined the protein expression of SMARCE1 and ki-67 through IHC ...
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AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells
... to MKN-1, MKN-28, and KATO-III cells transfected with control-shRNA and ...decreased cell viability in ARID1A-knockdown MKN-28 and KATO-III cells, compared to wild-type cells ...
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<p>High expression of GMⅡ is associated with poor prognosis of gastric cancer patients</p>
... mediated cell – cell adhesion instability, 29 the β 1,6-branched chain on the N-glycan of the tumor α 5 β 1 integrin β 1 subunit can down-regulate the formation of focal contact, thereby increasing tumor ...
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An Over Moded TEM Cell System for in vivo Exposure at 2 45 GHz
... TEM cell if the samples are correctly positioned within the ...TEM cell loaded with mouse phantoms of different ...TEM cell specially designed at such a frequency, which does not permit in vivo ...
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The Ninth Grove Fuel Cell Symposium38-45
... Michael Fübi (RWE Fuel Cells, Germany) pro- vided an overview of the stationary fuel cell market. There is increasing interest in utilising renewable energy, with manure, sewerage and farm wastes, coal mine and ...
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Synthesis and characterization of a glycine- modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging
... blood cell count, red blood cell count, hemoglobin, platelet count, serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, and total ...
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Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation
... EBV-positive cell lines that originate from various tumors [8, 9, 17, 19, 34, ...epithelial cell tumors but not in lymphoblastoid cell lines (LCLs) or B cell ...among cell types may ...
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