MKP-2
Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function
... Thus, MKP-2 deletion adversely affected the ability of cells to differentiate into adult macrophages over the 10-day ...of MKP-2 enhanced ERK activation, but it had no significant effect upon ...
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MOLECULAR EVENTS IN PROSTATE CANCER: LENTIVIRUS INDUCED KNOCKDOWN OF HUMAN MKP 2 ENHANCES ERK SIGNALLING IN LNCaP (AI) CELLS
... If MKP-2 is deleted or inactivated then there is the clear potential for ERK activity to be prolonged and whilst this may not result in the mitogenic of EGF to be enhanced, for agonists which generate a ...
10
T cell hypo-responsiveness against Leishmania major in MAP kinase phosphatase (MKP) 2 deficient C57BL/6 mice does not alter the healer disease phenotype
... MKP-2 2/2 (open symbols) and MKP-2 +/+ (closed symbols) grown on cover slips were infected with L. major promastigotes at a multiplicity of infection (MOI) of 5. One hour after ...
11
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... by MKP-2. This suggests MKP-2 deletion may have effects which regulate other compo- nents of the ERK cascade including receptor expression and functional coupling to upstream ...that ...
9
MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice
... whether MKP-2 2/2 or MKP-2 +/+ macrophages were ...activated MKP-2 +/+ macrophages, activated MKP-2 2/2 macrophages were equally able to ...
14
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana
... TLR-4. MKP-2 deletion had little effect upon the ERK response (Panel B) or p38 MAP kinase signalling (not shown) in response to promastigotes and JNK phosphorylation was only marginally increased although ...
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Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory
... hippocampal MKP-2 ⫺/⫺ cul- tures was seen that could account for the increased sEPSC ...for MKP-2 in inhibitory ...in MKP-2 ⫺/⫺ ...in MKP-2 ⫺ / ⫺ ...
7
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... by MKP-2. This suggests MKP-2 deletion may have effects which regulate other compo- nents of the ERK cascade including receptor expression and functional coupling to upstream ...that ...
9
MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells
... whether MKP-2 is also a potential mediator of the peripheral immune responses in CNS inflam- matory disease, we next determined the expression levels of MKP-2 in the spleen and dLN tissues ...
13
Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells
... for MKP-2 (Rahman et ...using MKP-2 we have identified, for the first time, the potential of JNK inhibition to enhance the expression of ICAM and VCAM, revealed only in conditions of partial ...
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Mitogen activated protein kinase phosphatase 1 in rat arterial smooth muscle cell proliferation
... (MKP-1, MKP-2, HVH2, and B23) that dephosphorylate and inactivate MAP kinases, MKP-1 has been studied the most ...extensively. MKP-1 inactivates p42 MAP kinase by dephosphorylating ...
9
MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
... type 2 diabetes mellitus ...of MKP-3 in vivo. Here, we have shown that expression of MKP-3 is markedly increased in the liver of diet-induced obese ...adenovirus-mediated MKP-3 overexpression ...
12
Mitogen-Activated Protein Kinase Phosphatase 1 Disrupts Proinflammatory Protein Synthesis in Endotoxin-Adapted Monocytes
... by MKP-1 phosphatase activity, which potentially dephosphorylates phos- phothreonine and phosphotyrosine residues, resulting in inacti- vation of MAPKs (38, ...that MKP-1 was induced in THP-1 cells at 1 h ...
9
The relapsing fever spirochete Borrelia miyamotoi is cultivable in a modified Kelly Pettenkofer medium, and is resistant to human complement
... medium”, MKP medium [26]. Besides more subtle differences, MKP medium differs from BSK-I and BSK-II medium by the ab- sence of glutamine and yeastolate, ...in MKP compared to BSK-II medium ...in ...
6
The 0/1 Multidimensional Knapsack Problem and Its Variants: A Survey of Practical Models and Heuristic Approaches
... 0/1 MKP as a test ...0/1 MKP; the binary PSO with time-varying accelera- tion coefficients, and the chaotic binary PSO with time-varying acceleration ...0/1 MKP, as well as a heuristic based on ...
45
Keller, Melanie (2005): Cytoprotective and Anti-Inflammatory Properties of the Atrial Natriuretic Peptide during Ischemia/Reperfusion and Endotoxemia. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Kiemer, AK, Weber, NC,[r] ...
147
Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1
... of MKP-1 in the lungs of the experimental animals were also ...and MKP-1 might balance each other at a com- paratively elevated baseline level within such an asthma ...
13
The whole genome sequence of Coxsackievirus B3 MKP strain leading to myocarditis and its molecular phylogenetic analysis
... pyrimidine, exists in the 5′untranslated region and binds to ribosome to start viral replication [11], nt88-181 is the re- gion which is a critical determinant of viral myocardial virulence. There was a pre-determined ...
9
5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability
... (reverse); MKP-1, 5’-AGG ACA CCA CAA GGC AGA C-3’ (for- ward) and 5’-TGA TGG GGC TTT GAA GGT AG-3’ (reverse); PPAR-a, 5’-TTC GGA AAC TGC AGA CCT- 3 ’ (forward) and 5 ’ -TTA GGA ACT CTC GGG TGA T- 3 ’ (reverse); ...
13
Fürst, Robert (2005): Identification of MKP-1 as a central mediator of cytoprotective effects in human endothelial cells: pathways of induction. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... HUVEC were grown until confluence on collagen-coated (collagen 1 % in PBS) glass coverslips (∅ 12 mm) in 24-well plates. Cells were treated as indicated in the respective figure legend. After treatment cells were washed ...
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