MMP-12
Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum
... as MMP-8 and MMP-9 (data not ...for MMP-12, given that any cross reactivity of the antibody with other MMPs, in particular MMP-8 and MMP-9, would saturate the capture antibody ...
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Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12
... target MMP is likely to result in the compensatory changes in these mice with altered expression of other ...of MMP-12 prevented the post-stroke upregulation of MMP-12, MMP-2 and ...
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MOLECULAR DOCKING AND 3D QSAR ANALYSIS STUDIES OF MMP 12 INHIBITORS
... In our ongoing project, further structural modification will be carried out as suggested by the quantitative structural activity relationship, which has been widely used in pharmacology in attempts to optimize drug ...
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Strain variation in response to lung ischemia: role of MMP-12
... on MMP-12 activity early and late in the process of neovascularization to de- termine potential mechanisms of ...that MMP-12 is overall angiostatic during lung ...
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Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD
... in MMP-12 expression in IS may be explained by predomi- nance of neutrophils, in COPD smokers and ex-smokers, which obviously do not express ...of MMP-12 in IS from 'healthy' smokers was ...
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Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice
... Growing evidence tends to establish TIMP-1 as a major fibrogenic effector in lung. Indeed, upon fibrogenic stim- uli, a large amount of TIMP-1 in the remodelling tissue is supposed to participate to the creation of a non ...
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Matrix metalloproteinases in cystic fibrosis: pathophysiologic and therapeutic perspectives
... that MMP-8 and MMP-9 promote excessive airway inflammation and structural injury in CF patients, but MMP-7 and MMP-12 may enhance clear- ance of bacteria from CF ...of MMP-8 and ...
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Matrix Metalloproteinase Expression Correlates with Virulence following Neurotropic Mouse Hepatitis Virus Infection
... of MMP-2, -9, -11, and -14, all expressed in naive and sham-infected mice, remained unchanged in immunosup- pressed mice at day 4 ...neither MMP-3 nor MMP-12 mRNA was detected in naive or ...
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COMPUTATIONAL UNDERSTANDING OF SELECTIVE MMP INHIBITORS IN COPD
... CONCLUSIONS: The aim of this work is to find out how selective inhibitors of MMP-09 and MMP-12 interact with respect to their intended enzymes. Our another aim is also to understand the similarities ...
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Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation
... and MMP-1 along with neutrophil elastase were signifi- cantly increased in COPD patients compared with healthy ...that MMP-12 is ne- cessary for macrophage recruitment in the lungs of smoke- exposed ...
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitor during Viral Encephalitis
... encoding MMP-3 and MMP-12. Whereas virus-induced MMP-3 expression was restricted to CNS resident astrocytes, MMP-12 mRNA was expressed by both inflammatory cells and CNS resident ...
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Induction and regulation of matrix metalloproteinase-12in human airway smooth muscle cells
... Total RNA was extracted from cultured ASMC by using the RNeasy Mini Kit (Qiagen, West Sussex, UK) according to the manufacturer's instructions. An aliquot of 0.5 µg total RNA was reverse transcribed using random hexamers ...
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Overlapping and enzyme specific contributions of matrix metalloproteinases 9 and 12 in IL 13–induced inflammation and remodeling
... wild-type, MMP-9–deficient, or MMP-12–deficient ...of MMP-9 or ...of MMP-9, while induction of MMPs-2, -9, -13, and -14 by IL-13 was diminished in the absence of ...in MMP-9 did ...
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Targets for medical therapy to limit abdominal aortic aneurysm progression
... Atorvastatin has been reported to prevent AAA development by suppressing macrophage recruitment via inhibition of MCP-1, MMP-12 and ICAM-1 but not MMP-9 expression in an elastase-induced[r] ...
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Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis?
... the MMP and TIMP probe sets and compared the 4 disease groups (control, non-EM uterine/pelvic disease, stage I/II EM, and stage III/IV EM) separately for each cycle phase documented (proliferative, early ...
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Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity
... group, MMP-12 levels were signifi- cantly higher in current smokers (P = ...Also, MMP-8 increased with smoking status (P for trend = ...group, MMP-8 and MMP-9 levels were higher in ...
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SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells
... to MMP gene promoters, we first identified putative YY1 binding sites on each genes using in silico bioinformatic analysis (Supplementary Figure ...the MMP genes’ promoter region containing the YY1 binding ...
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Original Article Downregulation of long non-coding RNA UCA1 is associated with the anticancer effects of isorhapontigenin on human bladder cancer cells
... polyclonal antibody (ab37150, Abcam, USA), anti-MMP-9 polyclonal antibody (ab38898, Abcam, USA), or anti-β-actin monoclonal anti- body (ab8226, Abcam, USA) for 1.5 h at room temperature. Subsequently, the membrane ...
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The initial steps of ovarian cancer cell metastasis are mediated by MMP 2 cleavage of vitronectin and fibronectin
... of MMP-2 in the host did not alter OvCa adhesion, as determined utilizing mice harboring homozygous null mutations in either the Mmp2 or Mmp9 ...of MMP-2 mRNA in OvCa cells. MMP-2 inhibition in OvCa ...
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Matrix metalloproteinase 3–dependent generation of a macrophage chemoattractant in a model of herniated disc resorption
... chondrocyte MMP-3 in the generation of a chemotactic factor that induces macrophage infiltra- ...tion. MMP-3–null discs did not allow macrophage infil- tration in the organ coculture model, and isolated ...
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