MMP-14
Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression
... of MMP expression remains ...the MMP-14 promoter. Experimentally, we found that p53 can repress MMP-14 promoter activity, whereas deletion of this p53 response element abrogated this ...
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MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer
... on MMP-14 [13, 14]. In EMT, MMP-14 and CD44 act ...vitro, MMP-14 and CD44 form a complex at the lamellipodia through the PEX domain in migrating cells ...
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Original Article TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis
... day 14, and day 21 compared with other ...process. MMP-14, which has been newly found and rarely studied in restenosis, was demonstrated to release latent TGF-β1 from the ECM by proteolytic ...
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Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development
... that MMP-14 plays a crucial role in this growth process; in particular, this is borne out by the phenomenon that MMP-14-deficient mice do not reproduce, whereas MMP-2-deficient mice ...
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An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy
... that MMP-14 is highly expressed in a panel of human solid tumors and poses as a potential molecular target for anticancer ...with MMP- 14 and that Lidamycin (LDM), an extremely potent ...
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The influence of MMP 14, TIMP 2 and MMP 2 expression on breast cancer prognosis
... and MMP-14) and the late Dr Anna Kossakowska, Calgary, Alberta ...and MMP-14) and pBS KS- (TIMP-2) vectors and were used as templates for in vitro transcription to generate sense and ...
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Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer
... This retrospective cohort study included all 116 patients diagnosed with ovarian cancer at St. Elisabeth Hospital and Tweesteden Hospital, both in Tilburg, the Netherlands, and at Amphia Hospital, in Breda, the ...
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Original Article Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells
... and MMP-14 in tumor progression, invasion, and ...increased MMP-14 expression pro- voked by their interaction, however, inhibition COX-2 activity and down-regulation of COX-2 expression ...
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Active synovial matrix metalloproteinase 2 is associated with radiographic erosions in patients with early synovitis
... joint, MMP-9 is expressed in macrophages in the synovial lining layer, in vascular endothelial cells, leuko- cytes, chondrocytes, and ...[11,28]. MMP-9 is inducible by inflammatory cytokines such as tumor ...
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Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis?
... the MMP and TIMP probe sets and compared the 4 disease groups (control, non-EM uterine/pelvic disease, stage I/II EM, and stage III/IV EM) separately for each cycle phase documented (proliferative, early ...
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COMPUTATIONAL UNDERSTANDING OF SELECTIVE MMP INHIBITORS IN COPD
... of MMP-09, -12, and -14 ...in MMP- 09, K421, V243 in MMP-12 and Q262, M264 in MMP- 14 are some of the key residues which could be responsible for active site volume and shape ...
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Effects of matrix metalloproteinases on the fate of mesenchymal stem cells
... of MMP-2 and MMP-14 through the activation of the MAPK signaling pathway [86], indicating a critical role of Ang II in the expression of MMP-2 and ...
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c Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma
... in human patients, and no contamination with other cell types was validated by EC-specific acetylated LDL (Ac-LDL) absorption in Aberrant vascularization is a hallmark of cancer progression and treatment resistance. ...
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Effect of topical fluoroquinolones on the expression of matrix metalloproteinases in the cornea
... Anesthesia was achieved by intramuscular injection of 0.5 ml/kg body weight of a mixture 1:1 of 100 mg/ml keta- mine and 20 mg/ml xylazine. Uniform corneal epithelial defects were created in the right eyes with the ...
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Matrix metalloproteinase 3–dependent generation of a macrophage chemoattractant in a model of herniated disc resorption
... that MMP-3 is required for pro- teolytic degradation of aggrecan, the major cartilage proteoglycan, and the loss of associated water mole- ...Although MMP-3 can cleave aggre- can at positions within the ...
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Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression<div><br /></div><div><br /></div>
... After 5, 15, or 25 days of treatment, the mice were euthanized with CO 2 gas. The dorsal skin sample of each mouse was excised from the line connecting both scapula, and fixed in 10% formaldehyde overnight. Embedded in ...
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Hesperidin Prevents Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via Suppressing TGF-β1 and MMPs Protein Expression
... 3.7 Effects of hesperidin and captopril on protein expression of MMP-2 and MMP-9 in aortic tissue 262. A significant increase in of MMP-2 and MMP-9 protein expression was observed in th[r] ...
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The initial steps of ovarian cancer cell metastasis are mediated by MMP 2 cleavage of vitronectin and fibronectin
... Host-derived MMP-2 and MMP-9 does not affect adhesion of OvCa ...preferentially MMP-2/-9 or a monoclonal antibody against MMP-9 or MMP-2, ...
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Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
... three MMP classes (interstitial collagenase, MMP-1; gelatinases, MMP-2 and MMP-9; and stromelysin, MMP-3) and their endogenous inhibitors (TIMPs 1 and 2) by immunocytochemistry, ...
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Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation
... Because MMP-1, MMP-3, and MMP-9 were released by fibroblasts in the presence of cytokines in their latent forms, trypsin was added to activate the MMPs in order to study their functional ...of ...
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