MMP-2
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
... in MMP-2 and MMP-9 levels was noted in the Dz13 cohort of animals compared to both the saline-treated and Scr-treated ...that MMP levels may fluctu- ate and even increase via activation, in ...
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Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
... regulate MMP activity and maintain ECM integrity, which control tumor ...of MMP-2, thus suppressing carcinoma invasion and metastasis, 23,24 which of ...
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The influence of MMP 14, TIMP 2 and MMP 2 expression on breast cancer prognosis
... of MMP-2 expression is not clear in the ...high MMP-2 mRNA or protein expression levels and a poor out- ...cases, MMP-2 overexpres- sion predicted a 15% greater risk of ...
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Elevated serum concentrations of metalloproteinases (MMP-2, MMP-9) and their inhibitors (TIMP-1, TIMP-2) in patients with Graves’ orbitopathy
... of MMP-2 and MMP-9, and their inhibi- tors, TIMP-1 and TIMP-2, in patients with GD, with and without GO, both in the active phase and after successful ...the MMP-9/TIMP-1 ratio, were ...
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The involvement of MMP 2 and MMP 9 in heart exercise related angiogenesis
... cells, MMP-2 promoter is subjected to a novel form of transcriptional regulation compared with the other ...of MMP-2 is associated with cardiac cellular response to damaging stress, such as ...
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The initial steps of ovarian cancer cell metastasis are mediated by MMP 2 cleavage of vitronectin and fibronectin
... Host-derived MMP-2 and MMP-9 does not affect adhesion of OvCa ...preferentially MMP-2/-9 or a monoclonal antibody against MMP-9 or MMP-2, ...
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Original Article Expression and significance of NF-κB and MMP-2 in deep vein thrombosis
... [17]. MMP-2 plays an important role in vascular repair. MMP-2 can regulate VEGF factor, as well as pro- mote angiogenesis and col- lagen activity, during colla- gen conversion [18, ...analyze ...
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Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels
... spectrum MMP inhibitor BB94 increased MT1-MMP expression, but decreased MMP-2 activation and did not alter pERK protein lev- els ...MT1- MMP and pERK levels, but decreased ...
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Id1 enhances human ovarian cancer endothelial progenitor cell angiogenesis via PI3K/Akt and NF κB/MMP 2 signaling pathways
... The molecular mechanism involved in EPC-induced tumor angiogenesis is poorly understood. VEGF and pla- cental growth factor (PlGF) have been shown to contrib- ute to EPC mobilization and homing into tumors [16]. Several ...
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Original Article Silencing of ILT4 suppresses migration and invasion of non-small cell lung cancer cells by inhibiting MMP-2
... cells, MMP-2 and MMP-9 are the most important enzymes that degrade type IV collagen and play an important role in tumor infiltration and metastasis ...of MMP-2 and MMP-9 has been ...
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Original Article Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium
... 19]. MMP-2 and MM- P-9 are the two major com- ponents of matrix metallo- proteinases ...of MMP-2 and MMP-9 in pe- ripheral blood or in synovi- al fluid of patients with rheumatoid ...
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Expression of the metalloproteases MMP 1, MMP 2, MMP 3, MMP 9, MMP 11, TIMP 1 and TIMP 2 in angiocentric midfacial lymphomas
... teases MMP-1 and MMP-11, whose mechanism is proba- bly related to the participation of the Epstein-Barr ...of MMP-2 and MMP-9 was not significant, as shown in other neoplasms, ...
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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... MT1- MMP expression. The interaction between β1 integrin and MT1-MMP blocks MT1-MMP internalization and causes increased MMP-2 ...stimulate MMP-2 acti- vation, and induce ...
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Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer
... as MMP-2, MMP-7, MMP-9, MMP-11 and MMP-14 has been reported and correlated with invasion and metasta- sis ...of MMP-14 has been demonstrated in ovarian clear-cell ...[9]. ...
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Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts
... of MMP-2 and MMP-9 were determined by RT-PCR and im- munoblotting with the levels of TIMP-1 and ...of MMP-2 in some presented situations (Jiao et ...of MMP-2 and ...
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MMP-2 (-29%), MMP-3 (-15%), MMP-9 (-29%), and MMP-13
... After 2 weeks of treatment, OA was induced by the injection of monosodium iodoacetate into the knee joint capsule of Sprague-Dawley ...of MMP-2 (-27%), MMP-3 (-19%), MMP- 9 (-40%), and ...
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Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development
... Figures 2-4 to 8 and ...that MMP-14 plays a crucial role in this growth process; in particular, this is borne out by the phenomenon that MMP-14-deficient mice do not reproduce, whereas ...
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Early and Late Changes of MMP 2 and MMP 9 in Bleomycin Induced Pulmonary Fibrosis
... (TIMP). 2 MMP-2 and MMP-9 are designated as 72-kDa gelatinase A and 92-kDa gelatinase B, respectively, and well known by their ability of degrading collagen type IV, the major constituent of ...
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Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
... Samples of villous tissue were taken randomly across the placenta from midsections of cotyledons (halfway between the maternal and fetal sides). Large vessels were removed using blunt dissection and leaving only villous ...
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Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation
... assess MMP release and conversion to active ...medium), MMP-1, MMP-3, and MMP-9 were undetectable (Figure 2A–C, respectively) whereas detectable MMP-2 was released into the ...
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