MMP-3
MMP-2 (-29%), MMP-3 (-15%), MMP-9 (-29%), and MMP-13
... of MMP-2 (-27%), MMP-3 (-19%), MMP- 9 (-40%), and MMP-13 (-15%) and the mRNA levels of MMP-2 (-29%), MMP-3 (-15%), MMP-9 (-29%), and MMP-13 ...
9
Influence of cytokine inhibitors on concentration and activity of MMP 1 and MMP 3 in disc herniation
... on MMP- 1 and MMP-3 ...affected MMP-3 levels, whereas dexamethasone was effective in decreasing concentrations of both MMP-1 and ...of MMP-1 and MMP-3 in DH ...
7
Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients
... of MMP-3 and MMP-9 increase together during disease eruption and decline significantly after successful treat- ment, which constitutes convincing proof of a connection between the analyzed factors ...
8
Expression of the metalloproteases MMP 1, MMP 2, MMP 3, MMP 9, MMP 11, TIMP 1 and TIMP 2 in angiocentric midfacial lymphomas
... of MMP-9 and MMP-2 ...of MMP-2, for a ternary complex with proMMP- 2 and MT1-MMP ...lines, MMP-9 is induced by the EBV latent membrane protein-1 (LMP-1), particu- larly in Burkitt's ...
9
Matrix metalloproteinase 3–dependent generation of a macrophage chemoattractant in a model of herniated disc resorption
... that MMP-3 is required for pro- teolytic degradation of aggrecan, the major cartilage proteoglycan, and the loss of associated water mole- ...Although MMP-3 can cleave aggre- can at positions ...
10
β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia
... that MMP-3, MMP-8, and MMP-9 are upregu- lated in LPS or α-synuclein-stimulated microglia and me- diate neuroinflammatory ...of MMP-3, MMP-8, or MMP-9 suppresses ...
15
High-frequency near-infrared diode laser irradiation attenuates IL- 1β -induced expression of inflammatory cytokines and matrix metalloproteinases in human primary chondrocytes
... against MMP-1 (Abcam, Cambridge, MA, USA; Cat# ab139332), MMP-3 (Abcam; Cat# ab52915), and β-actin (Wako, Osaka, Japan) and then incubated with Alexa Fluor 680-labeled anti-rabbit secondary antibody ...
13
Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling 3
... and MMP-13 were obtained from Metabion International AG (Martinsried, ...mouse MMP-3 mRNA was measured using TagMan Gene Ex- pression Assay (Mm00440295_m1, Applied ...
13
Matrix metalloproteinase 3 inhibitor retards treadmill running induced cartilage degradation in rats
... rat MMP-3 (1:50 dilution, Santa Cruz Biotechnology, Santa Cruz, CA, USA) for ...for MMP-3 in the joint cartilage was evaluated by calculating the ratio of the number of MMP-3 ...
11
Tweet
... spectrum, MMP-3 initially was considered primarily in relation to its role in ...this MMP have been revealed. Indeed, as we outline in the present review, MMP-3 plays a crucial role in ...
6
Adiponectin is a potential catabolic mediator in osteoarthritis cartilage
... suppressed NO production, whereas it caused a higher MMP-3 production in adiponectin-treated ATDC5 cells in the study of Lago et al. [13]. In this context, we are tempted to speculate that NO serves as a ...
11
Curcumin slows osteoarthritis progression and relieves osteoarthritis associated pain symptoms in a post traumatic osteoarthritis mouse model
... (Fig. 3) exerts broad chon- droprotective effects in human primary chondrocytes by suppressing the expression of genes encoding inflamma- tory cytokines IL-1β and TNF-α, and cartilage-degrading enzymes from the ...
12
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β
... follows: MMP-1 (1:800 dilution, Aviva), MMP-3 (1:1,000 dilution, Aviva), MMP-13 (1:1,000 dilution, Aviva), FN1 (1:1,000 dilution, Aviva), TSP1 (1:1,000, ...
12
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β
... of MMP-1, MMP-3, and MMP-13 within in vitro models of cartilage inflammation can be used as screening systems for drugs and anti-inflammatory ...inhibit MMP release and activation and ...
12
Glucosamine affects intracellular signalling through inhibition of mitogen activated protein kinase phosphorylation in human chondrocytes
... Imbalance between catabolic and anabolic factors in OA leads to degradation of articular cartilage. Catabolic factors include proinflammatory cytokines IL-1β and tumour necrosis factor-α, which stimulate intracellular ...
9
Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis
... dilution), MMP-13 (MAB3321, Chemicon International, Temecula, CA, USA; 1:1,000 dilution), Sox9 (AB5535, Chemicon International, Temecula, CA, USA; 2 μ g/ml), Runx2 (sc-10758, Santa Cruz Biotech- nology, Santa ...
12
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes
... to joint pain in experimental OA. In addition, Moilanen et al. [27] reported that TRPA1-deficient mice developed less severe cartilage changes following MIA injections. Accord- ingly, we showed here that TRPA1 is ...
11
Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation
... of MMP expression, the expression of MMP-1, MMP-3, MMP-9 and MMP-2 was examined in shCOX-2 ...EGF-induced MMP-1 and MMP-3 expression was significantly ...
17
Original Article Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model
... (MMP-1), MMP-3, MMP-13, tissue inhibitors of metalloproteinase-1 (TIMP-1), inducible nitric oxide synthase (iNOS) and cyclooxygen- ase (COX)-2 was determined by quantitative real-time ...
10
Original Article Effects of low-intensity focused ultrasound on cartilage and synovium in an experimental model of osteoarthritis in rabbits
... of MMP- 1, MMP-3, MMP-13, and TIMP-1 was quantitat- ed by real-time quantitative PCR using the iCy- cler apparatus system (Bio-Rad, ...
11