MMP activity
Measurement of MMP Activity in Synovial Fluid in Cases of Osteoarthritis and Acute Inflammatory Conditions of the Knee Joints Using a Fluorogenic Peptide Probe-Immobilized Diagnostic Kit
... individual MMP in SF from patients, gelatin zymography and Western blot- ting using the MMP-13 antibody were ...revealed MMP activity at 72 kDa and 92 kDa (Fig. 3C). MMP activity ...
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Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
... catalytic domain of MMP proenzymes, and thus, its activity can be detected upon development of the zymogram. We performed infections with two different wt virus stocks (Fig. 7, lanes 2, 3, 8, and 9) and ...
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Proteolysis in human breast and colorectal cancer
... total MMP activity was significantly greater in the tumour tissue and this may be rele- vant in tumour invasion and ...metastasis. MMP activity was greater in colorectal tumour and normal ...
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Activity of Matrix Metalloproteinase 2 and 9 in Follicular Fluid and Seminal Plasma and Its Relation to Embryo Quality and Fertilization Rate
... the MMP-2 and 9 activities in men reproductive sys- tem (3, ...between MMP-2 activity in semi- nal plasma and fertilization and embryo ...higher activity of MMP-2 of seminal plasma ...
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Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation
... lessened MMP-9 enzyme activity as well as the expression of MMP-9 mRNA and ...dampened MMP-9 gene transcription by affecting the expression of transcriptional coactivators, such as ...
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Successful implantation after reducing matrix metalloproteinase activity in the uterine cavity
... Abnormal MMP expression is involved in the pathogenesis of autoimmune diseases, cancer, endometriosis, and other inflammatory diseases [7], although MMPs are also cru- cial for the normal physiology of the ...
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Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas
... block MMP activity, we measured the extent of doxycyline- mediated MMP-2 and MMP-9 inhibition in vitro using epidermal growth factor receptor (EGFR) transfected U251 glioma cell ...lines. ...
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Influence of cytokine inhibitors on concentration and activity of MMP 1 and MMP 3 in disc herniation
... the activity assay used in this study, MMP-1 or MMP-3 is captured by a specific antibody that has been immobilized on a microtiter ...active MMP is measured directly by the incubation of the ...
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Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts
... of MMP-2 and MMP-9 were determined by RT-PCR and im- munoblotting with the levels of TIMP-1 and ...the activity of MMP-2 in some presented situations (Jiao et ...of MMP-2 and ...
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Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity
... of MMP in ventilator-induced lung injury ...higher MMP and Timp-1 levels in BAL from ventilated patients compared to non-ventilated ...on MMP release and activation (figure ...with MMP release ...
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Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
... that MMP-2 and MMP-9 that were secreted by leukemic cells increased blood-brain barrier permeability by disrupting tight junction pro- teins, which contributed to the invasion of leukemic cells to the ...
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ROLE OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ENDOMETRIOSIS IN WOMEN WITH INFERTILITY
... of MMP-1, MMP-2, ММР-3, MMP-7 and MMP-9, and the decrease of TIMP-1 and TIMP-2 ...of MMP activity, whether due to the increase of MMP expression or the decrease of TIMP ...
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Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits
... sharp activity peaks present in control ...of MMP activity levels that occurred earlier than with administration of PBS and Solcoseryl (Figure ...of MMP-2, MMP-8, and MMP-9 ...
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Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development
... of MMP-14 and MMP-2 in human follicular growth and development, as tissue is not readily ...of MMP- 14 and MMP-2 in ovarian physiology is difficult to investi- ...induce MMP- ...
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MMP-2 (-29%), MMP-3 (-15%), MMP-9 (-29%), and MMP-13
... Osteoarthritis (OA) is the most common cause of joint pain, affecting about 15% of the popu- lation, and is considered a major public health problem worldwide. It is an inflammatory dis- ease that is common in the ...
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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
... rhTNF-α-induced MMP-3 protein expression and activity Since stromelysin-1 (MMP-3) contributes to BBB disruption during lipopolysaccharide (LPS)-induced neuroinflammation (Gurney et ...on MMP-3 ...
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New insights on the MMP 13 regulatory network in the pathogenesis of early osteoarthritis
... main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), ...
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Estrogen receptor beta and truncated variants enhance the expression of transfected MMP-1 promoter constructs in response to specific mechanical loading
... the MMP-1 promoter to mechanotransduc- tion stimuli such as the fluid-flow-induced shear stress and equibiaxial ...2G MMP-1 promoter activity. Moreover, the 2G form of MMP-1 exhibited a ...
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Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer
... GAGT-3′; MMP-2 forward 5′-TGATCTTGACCA GAATACCATCGA-3′; reverse 5′-GGCTTGCGAGGG AAGAAGTT-3′; MMP-9 forward 5′-CCTGGAGAC CTGAGAACCAATC-3′; reverse 5′-CCACCCGAGT GTAACCATAGC-3′; VEGF-A forward 5′-CTTGCCT ...
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Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity
... This study had several limitations. First, we could not control the influence of cement dust on subjects because we used data obtained from the CODA cohort. The influence of cement dust on MMPs has not been documented, ...
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