MMP2/9
CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway
... extracellular matrix to promote metastasis in tumor [53–56]. Similarly, we identified CCL2/CCR2 axis as a tumor promoter in NPC metastasis through upregulating MMP2/9 via ERK1/2 pathways. Besides, in other ...
16
Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats
... leading to enhancement of NMDA receptor activity by NR1 subunit phosphorylation [19]. Activation of NMDA receptors subsequently induces Ca 2+ influx and activates downstream signal cascade such as CaMKII [20]. These ...
12
Role of matrix metalloproteinase-2/9 (MMP2/9) in lead-induced changes in an in vitro blood-brain barrier model
... transferred to nitrocellulose membranes (Millipore, Billerica, MA, USA). After blocking for 1 h with 8% skimmed milk in TBS buffer (10 mM Tris, 150 mM NaCl), the membrane was incubated overnight at 4 °C with primary ...
10
Protein hydrolysate from potato confers hepatic protection in hamsters against high fat diet induced apoptosis and fibrosis by suppressing Caspase 3 and MMP2/9 and by enhancing Akt survival pathway
... Apoptosis and associated events prompt the migration of stellate cells to the region of apoptosis to engulf the apoptotic bodies in the liver. Hepatic stellates in the site of tissue damage involves in the deposition of ...
8
Original Article The association study of MMP2 polymorphisms with susceptibility to adolescent idiopathic scoliosis in Han Chinese
... SNPs can be divided into two categories: cod- ing SNP, located at genomic coding region, and non-coding SNP, at non-coding region. Non- coding SNPs are distributed at intron, 5’ un- translating region (UTR), 3’-UTR and ...
7
MMP2 and MMP7 at the invasive front of gastric cancer are not associated with mTOR expression
... The degradation of the extracellular matrix by matrix metalloproteinases (MMPs) is essential for invasive be- haviour of gastric cancer [1–3]. Expression of MMPs can be induced by specific growth factors [4, 5], and de- ...
5
Analysis of MMP2 promoter polymorphisms in childhood obesity
... The genetic association we report in the MMP-2 pro- moter may result from altered MMP expression, as the 3 SNPs investigated are all functional SNPs capable of affecting transcriptional activity. Indeed, associations ...
5
Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane
... gene expression in vascular endothelial cells [34]. Faruk et al. [13] found that fibroblast metabolism could be altered by nicotine action and intercellular matrix synthesis was affected. It also affects periodon- tal ...
7
Interaction of HE4 and ANXA2 exists in various malignant cells—HE4–ANXA2–MMP2 protein complex promotes cell migration
... ANXA2 is a HE4-interacting protein in ovarian can- cer which was discovered by our research group through mass spectrum analysis in the preliminary phase [9]. ANXA2, a member of the annexin family, is a calcium- ...
12
Development of an aptamer conjugated fluorescent nanoprobe for MMP2
... a MMP2-specific ...a MMP2-specific aptamer which had high affinity and specificity and showed the possibility that it can be applied for molecular ...
7
Combined effects of interleukin-1β and cyclic stretching on metalloproteinase expression in corneal fibroblasts in vitro
... Type IV collagen and type V collagen are distributed in the basement membrane of the corneal epithelium and the corneal stroma, which provide the majority of the tensile strength of the cornea [7]. The destruction of ...
10
α-Lipoic Acid Modulates Extracellular Matrix and Angiogenesis Gene Expression in Non-Healing Wounds Treated with Hyperbaric Oxygen Therapy
... MMP2 and MMP9 activities in biopsy samples were assessed by an immuno- capture assay using a commercially available kit according to the manufac- turer’s protocol (Amersham Biosciences, Piscataway, NJ, USA), using ...
9
Original Article Association between matrix metalloproteinase gene polymorphisms and development of ischemic stroke
... between MMP2 rs243865, MMP3 rs3025058 and MMP9 rs3918242 polymorphisms and development of ischemic stroke in a Chinese ...The MMP2 rs243865, MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were analyzed ...
6
Blood Droplet-Based Cancer Diagnosis via Proteolytic Activity Measurement in Cancer Progression
... that MMP2 secretion does not occur for normal ...to MMP2 molecules secreted from tumors for all 15 lung cancer patients are presented in Figure ...by MMP2 is measured in a range of 150 to 600 pg, and ...
10
Comparison of Matrix Metalloproteinases 2 mRNA Expression in Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia
... of MMP2 in either the carcinoma or the hyperplasia tissues ...al. MMP2 was most active in the advanced stages of the disease (PT2-PT3) and with a GS>7 ...
12
In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane
... Fertilized white leghorn chicken eggs were purchased from Tamil Nadu Poultry Research Station, Madras Vet- erinary University, Nandanam, Tamil Nadu, India. Gel- atin sponges purchased from Jhonson & Jhonson Pvt Lmtd, ...
13
Original Article MMP2 rs243865 genotypes are associated with the increased risk of renal cell carcinoma in Chinese Han population
... of MMP2 genotypes were signifi- cantly different between case and control gro- ups, indicating that this SNP might be related to RCC ...of MMP2 and 3 gene polymor- phisms as a risk factor for RCC and found ...
6
A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/AkT/MTOR signaling pathway
... To investigate the effect of a PD-L1 blockade on pancreatic cancer and metastasis, we established an orthotopic pancre- atic cancer animal model, and then used it to analyze rela- tionships between the levels of PD-L1 ...
12
EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway
... AEG-1 increases the invasiveness of HeLa cells by activating the NF-κB pathway [14]. AEG-1 expression is significantly induced by oncogenic Ha-ras through the PI3K/AKT/GSK3β/c-Myc signaling pathway [15]. In addition, ...
18
Controlled release strategy of paclitaxel by conjugating to matrix metalloproteinases-2 sensitive peptide
... known, MMP2 plays a critical role in tumour progression, tumour angiogenesis and metastasis; thus a cellular scratch assay was performed for investigating the metastasis inhibition of ...
9