MMTV-PyMT
Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
... To determine if this pattern of stromal NG2 expression also occurs in human mammary tumors, we examined samples from a panel of 11 non-triple negative human ductal adenocarcinomas (Table 1). In the majority of these ...
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Treatment response assessment with (R)-[11CPAQ PET in the MMTV-PyMT mouse model of breast cancer
... B20-4.1.1 is a cross-species monoclonal antibody targeting both human and murine VEGF [26], and it has been used to treat various preclinical tumor models [37, 38]. Anti-VEGF blocking depends on both the tumor context ...
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Anti matrix metalloproteinase 9 DNAzyme decreases tumor growth in the MMTV PyMT mouse model of breast cancer
... and MMTV-PyMT Transgenic Mice and Is Safe; manuscript in review) should enhance the clinical response of solid tumors, including breast tumors, to AM9D treatment, while evading the serious side effects ...
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Pleiotropic functions of the tumor and metastasis suppressing matrix metalloproteinase 8 in mammary cancer in MMTV PyMT transgenic mice
... the MMTV-PyMT model, which leads to rapid, multifocal tumor formation in the mammary gland and a high frequency of lung metastasis [22,33], homozygous loss of MMP-8 further accelerated tumor onset, ...
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Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
... (i.e., MMTV-PyMT mice and MMTV-Neu mice, ...significantly; MMTV-PyMT mice start to de- velop primary tumors at 9 weeks of age and develop lung metastasis after 14 weeks of age, whereas ...
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Proteolysis–a characteristic of tumor-initiating cells in murine metastatic breast cancer
... that MMTV-PyMT TICs undergo an EMT process and support the formation of TIC- derived metastases in the lungs after orthotopic fat pad transplantation of these cells as observed in our ...
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Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen mediated mammary gland tumorigenesis and metastasis
... The MMTV-PyMT mouse model is an extremely aggressive, well- characterized breast cancer model in which mice develop multifocal mammary tumors at a median age of 6– 7 ...
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MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer
... the MMTV LTR (mouse mammary tumor virus long terminal repeat) ...the MMTV LTR promoter and are regulated by the estrous cycle in the mammary ...the MMTV LTR promoter are highly up regulated during ...
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IMP1, an mRNA binding protein that reduces the metastatic potential of breast cancer in a mouse model
... Previous studies have shown that expressing IMP1 could enhance persistence and directionality [17] and induce polarity in breast tumor cells in culture [4, 18]. It has been reported that IMP1 expression is decreased in a ...
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The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
... In the MMTV-PyMT model, loss of SRC-1 also correlated closely with reduced expression of the HER2 oncogene as well as with re- duced levels of the steroid independent transcri[r] ...
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Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth
... of PyMT-positive lesions in the PyMT mouse model of breast ...− PyMT mice were increasing in size more ...+/+ PyMT mice and AREG −/− PyMT mice were ...larger PyMT-positive area ...
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Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
... of MMTV-PyMT MICs might be regulated by the activity of other pathways, such as WNT (Figure 1A), we selected a broader mesenchymal cancer cell pool expressing AXL, including the MIC (CD24 + CD90 + ) ...
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Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis
... of MMTV-Neu mice shortened tumor latency and increased tumor proliferation, which was associated with increased levels of MCFA (carbon chain ...from MMTV- PyMT mice resulted in slower tumor growth, ...
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Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
... Whilst MMTV- PyMT tumour-derived cell lines extended invasive protrusions in medium with reduced glucose concentration, depletion of glutamine significantly reduced protrusion length indicating that ...
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PubMedCentral-PMC5296251.pdf
... use. MMTV-PyMT cells were purchased from ATCC (Manassas VI, USA), which validate cell lines by Short Tandem Repeat profiling, transduced with lentiviruses expressing Firefly Luciferase (fLUC) (Perkin Elmer, ...
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Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors
... additional MMTV-PyMT mammary tumor-bearing mice, before and after Alk5 inhibitor treatment (n = 8) or PBS treatment (n = 8), underwent in vivo measurements of tumor IFP via the “wick-in-needle technique” ...
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Is MMTV associated with human breast cancer? Maybe, but probably not
... the MMTV-related human endogenous HERV-K family of retroviruses served as an outgroup (GenBank ac- cession nos: AF020092, AF012336, AF164612, AF164614, AF164615, AF164610, M14123, AF164613, AF164609, ...
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Genetics of Mouse Mammary Tumor Virus-Induced Mammary Tumors: Linkage of Tumor Induction to the gagGene
... with MMTV(HeJ) developed mammary tumors by 292 days ...by MMTV(HeJ) (data not shown). Thus, both MMTV(HeJ) and HP were capable of causing mammary tumors in BALB/cJ mice but not in tumor- susceptible ...
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Systematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cells
... individual MMTV insertions appear to be sufficient for tumor formation in mouse, but in MCF10A cells, overexpression of the corresponding single protein can- not induce strong soft agar ...with MMTV in ...
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Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer
... an MMTV–like virus in human breast cancer is as follows: (i) a meta- analysis of 22 studies concluded that the identification of MMTV–like gene sequences in breast cancer tissues, was associated with a 15 ...
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