Molecular alterations
Molecular alterations in endometrial cancer: implications for clinical management
... and molecular alterations were tested using Chi-square statistics or Fishers exact test in case of categorical and t test or analysis of variance (ANOVA) for continuous ...
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Genetic/molecular alterations of meningiomas and the signaling pathways targeted
... Meningiomas are usually considered to be benign central nervous system tumors; however, they show heterogenous clinical, histolopathological and cytogenetic features associated with a variable outcome. In recent years ...
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Molecular Alterations Associated with Osteosarcoma Development
... the molecular mechanisms of metastasis ...of molecular alterations can provide the identification of novel therapeutic targets and/or prognostic markers for osteosarcoma treatment to improve the ...
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Molecular alterations that drive breast cancer metastasis to bone.
... the molecular alterations undertaken by breast cancer cells at each stage of the metastatic cascade and discuss how these changes facilitate bone ...
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The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia
... gene. Alterations of the p53 gene were found in the myeloid and the rare megakaryocytic variant of blast crisis but were absent in the lymphoid leukemic ...structural alterations were seen in 11 of 54 (20%) ...
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Updates on the Role of Molecular Alterations and NOTCH Signaling in the Development of Neuroendocrine Neoplasms
... Gastrointestinal (GI) tract and the pancreas are two of the most common sites of origin for NENs. Tumours arising from these organs are named gastroenteropancreatic NENs (GEP NENs) and they represent almost the 65% of ...
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Molecular alterations in the TCR signaling pathway in patients with aplastic anemia
... In conclusion, this is the first study to analyze the expression characteristics of the CD28, CTLA-4, and Cbl-b genes, the distribution of the CD3 ζ 3 ′ -UTR splice variant in AA patient[r] ...
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Molecular alterations and clinical prognostic factors for cholangiocarcinoma in Thai population
... Statistical analyses were performed using STATA software v.13 (StataCorp LP, College Station, TX, USA). OS and progression-free survival (PFS) were calculated and censored on January 31, 2015. OS and PFS curves were ...
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Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment
... multicenter molecular studies are needed to increase the amount of available ...genetic alterations of low-grade (I-III) and high-grade (IV) ONB and such studies should be ...
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Integrative molecular analysis of metastatic hepatocellular carcinoma
... progressive molecular alterations between primary tu- mors and matched ...consistent molecular alterations can be found between primary tu- mors and matched ...progressive molecular ...
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Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine
... cognate molecular alterations would not be effective in solid tumors because they are too heterogeneous and complex, but in 2007, we began the IMPACT (Initiative for Molecular Profiling and Advanced ...
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Right-sided rhabdoid colorectal tumors might be related to the Serrated Pathway
... Figure 2 Genetic and epigenetic survey of a composite and pure rhabdoid tumor. (A). Genetic, cytogenetic and epigenetic analysis of the pure RCT (case I) and composite (case II) RTC. Tumor tissue of case II is ...
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Immunological outcomes of exercise in older adults
... and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders ...
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Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors
... Nevertheless, apart from activating mutations of KIT or PDFGRA, our understanding of fine molecular alterations implicated in GISTs pathogenesis are limited. At present, there is no recommendation for ...
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Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer
... of molecular changes in the progression from PanIN to PDAC with the establishment of genetically modified animal models that recapitulate these changes ...Such molecular alterations provide a road ...
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Molecular driver alterations and their clinical relevance in cancer of unknown primary site
... one molecular alteration in 46 out of 55 cases (84%), including mutations in 43 cases (78%) and CNVs (amplifications/deletions), as revealed by coverage analysis, in 29 cases ...6 molecular ...
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<p>Incidence and PD-L1 Expression of <em>MET</em> 14 Skipping in Chinese Population: A Non-Selective NSCLC Cohort Study Using RNA-Based Sequencing</p>
... These alterations lead to increased MET stability and oncogenic potential and confer sensitivity to MET tyrosine kinase inhibitors (TKIs), such as crizotinib and ...14 alterations in 951 Chinese NSCLC ...
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Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome
... lar alterations induced during a period of poor or no con- trol cannot be reversed by subsequent good glycemic control and that other molecular alterations are not pre- vented from developing after ...
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<p>Anticancer activity of 1, 25-(OH)<sub>2</sub>D<sub>3</sub> against human breast cancer cell lines by targeting Ras/MEK/ERK pathway</p>
... these molecular alterations, the alterations of breast cancer cell functions including growth, proliferation, migration, invasion, cell cycle progression, and apoptosis caused by 1,25-(OH) 2 D 3 were ...
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Early events in ovarian oncogenesis
... identify molecular pathways and genes leading to ovarian cancer and to determine if each histological subtype evolves as a result of a separate set of molecular ...[63]. Molecular profiling of EOC's ...
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