molecular basis
Molecular basis of alpha-thalassemia
... α-Thalassemia is an inherited, autosomal recessive, disorder characterized by a microcytic hypochromic anemia. It is one of the most common monogenic gene disorders in the world population. The clinical severity varies ...
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Finger or toe: the molecular basis of limb identity
... the molecular basis by which limb-type morphologies are produced, is certain to enhance our understanding of the broader issue of how organisms have reused regulatory signalling cascades in diverse ...
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Molecular basis of human cerebral malaria development
... Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite ...
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Molecular Basis of α-Thalassemia in Iran
... from molecular studies of α-thal carriers and HbH disease patients in Iran shows a high heterogeneity of ...on molecular basis of α-thal in Iran shows the high heterogeneity of alleles causing the ...
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Molecular basis of barley quality
... Analysis of allelic variation in key genes using genomic approaches is advancing our understanding of barley quality. SNP analysis and associated genetic approaches allow alleles to be efficiently distinguished and ...
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The molecular basis of the acclimatization of plants to chilling temperatures
... THE MOLECULAR BASIS OF THE ACCLIMATIZATION OF PLANTS TO CHILLING TEMPERATURES John Wilson A Thesis Submitted for the Degree of PhD at the University of St Andrews.. 1974 Full metadata fo[r] ...
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Molecular Basis of Bacterial Longevity
... Several features of the physiology of the phototrophic alphaproteobacterium Rho- dopseudomonas palustris suggest that it represents an ideal model for characterizing the molecular basis of bacterial ...
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Molecular Basis for Lytic Bacteriophage Resistance in Enterococci
... IMPORTANCE Bacteriophage therapy has received renewed attention as a potential solution to the rise in antibiotic- resistant bacterial infections. However, bacteria can acquire phage resistance, posing a major barrier to ...
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Molecular basis of lactase levels in adult humans
... The molecular basis of adult human "lactase deficiency" has long been a subject of controversy. To address this issue, small intestinal biopsies from orienta, black, and white patients were ...
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Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″) Ia
... IMPORTANCE To successfully manage the threat associated with multidrug-resistant infectious diseases, innovative therapeutic strategies need to be developed. One such approach involves the enhancement or potentiation of ...
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Molecular Basis and Ecological Relevance of Caulobacter Cell Filamentation in Freshwater Habitats
... Uncoupling of cell growth from major cell cycle processes leads to cell fila- mentation. Our method to enrich filamentous cells enabled us to investigate the molecular basis of filament formation. Bacteria ...
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Implantation: molecular basis of embryo uterine dialogue
... HB-EGF appears to have an expression pattern highly relevant to the implantation process. In the mouse, it is induced exclusively in the luminal epithelium at the site of blastocyst apposition 6-7 hours before the ...
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Molecular basis of Sindbis virus neurovirulence in mice.
... These recombinant viruses allowed us to test the importance of each amino acid difference between the various strains for neurovirulence in weanling and suckling mice.. Glycoproteins E2 [r] ...
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The Molecular Basis of Von Hippel-Lindau Disease
... (1994) Germ-line mutations in the von Hip- pel-Lindau tumor suppressor gene are simi- lar to somatic von Hippel-Lindau abbera- tions in sporadic renal cell carcinoma.. (1996) Germline mu[r] ...
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Molecular Basis of Human CD36 Gene Mutations
... or molecular back- ground of type II CD36 deficiency is not clearly understood and is probably heterogenous, leading to confounding interpretations of cause-and-effect rela- tionships in human CD36 deficiency ...
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The molecular basis of cytochrome oxidase deficiency in childhood
... In addition immunoblot analysis revealed increased steady-state levels of other respiratory chain and oxidative phosphorylation subunits: flavin protein of SDH, core 1 subunit of c[r] ...
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The molecular basis of chemokine action in human endometrium
... Figures 1.1 Anatomy of the female reproductive tract 1.2 Maturation of human ovarian follicles 1.3 The structure of the human endometrium 1.4 Effects of cyclic hormonal changes on the me[r] ...
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THE MOLECULAR BASIS OF DOMINANCE
... It is intuitively obvious that there is a relationship between the value of the sensitivity coefficient of the wild type, whose magnitude describes the differential response at[r] ...
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Molecular basis of cyanophage resistance in marine Synechococcus
... following infection of a phosphate-depleted Synechococcus host by cyanophage S-PM2 Wilson et al., 1996, all cyanophages isolated on marine Synechococcus thus far follow an obligately lyt[r] ...
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Raltegravir: molecular basis of its mechanism of action
... and molecular determinants of raltegravir potency are now well understood and the nature of the interactions with its target in the context of the integrase/vDNA complex is beginning to be elucidated owing to the ...
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