molecular events
Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis
... Epidemiological studies have demonstrated an increased leukemia incidence following ionizing radiation exposure, but to date, the target cells and underlying mechanisms of radiation leukemogenesis remain largely unidenti ...
10
Molecular Events in the Cardiomyopathy of Sepsis
... These events are likely to decrease the activity of the adenylyl cyclase, resulting in decreased intracellular levels of cyclic adenosine monophosphate (cAMP), paralyzing the ...
10
Modeling the neuron as a nanocommunication system to identify spatiotemporal molecular events in neurodegenerative disease
... communication events with greater detail and which can link multiple processes to specific outcomes will better reflect the intracellular biological complexity and improve overall neurodegenerative disease ...
24
Molecular events in the cell types of the olfactory epithelium during adult neurogenesis
... of molecular functions performed by the products of each of the genes, but also revealing emergent properties formed by the functional relationships between the encoded ...
14
Review Article Morphologic and Molecular Events at the Invading Edge of Colorectal Carcinomas
... We recently found at the invading edge of CRCs that laminin α2 chain, a trimetric matrix protein localized at the basement membrane in many organs, was overexpressed in the neoplastic cells limiting to the glandular ...
7
Experimental Analysis of Molecular Events During Mutational Periodic Selections in Bacterial Evolution
... selection events causing a change in the frequency of neutral mutations (in fhuA causing phage T5 resistance), were identified with changes at particular ...
9
A coding IRAK2 protein variant compromises Toll like receptor (TLR) signaling and is associated with colorectal cancer survival
... precise molecular events of signal transduction still remain elusive, but DD-me- diated Myddosome formation is supposed to enable proximity- induced activation of IRAK4 and IRAK1 or IRAK2, which, by an ...
10
Anthelmintic resistance: the song remains the same
... of molecular events are obviously in- volved, there is a general consensus that re- version to susceptibility is rare once resistance has developed, even when other drugs with completely different working ...
12
Identification and Characterization of a Transcription Pause Site in Rotavirus
... early molecular events in transcription, we used high-resolution polyacrylamide gel electrophoresis to investigate the length distribution of transcription prod- ucts at various times following ...specific ...
11
CHANGES IN SERUM IGE LEVELS BEFORE AND AFTER IMMUNOTHERAPY IN PATIENTS WITH ALLERGIC AIRWAY DISEASES
... population in industrialized countries with a still increasing incidence. [3] Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role, it is a major health problem ...
6
Regulation of procollagen metabolism in the pressure overloaded rat heart
... the molecular events responsible for the disproportionate accumulation of myocardial fibrillar collagens during sustained hypertension, we examined the in vivo rate of procollagen synthesis, collagen ...
11
Cyclic AMP regulates PDGF stimulated signal transduction and differentiation of an immortalized optic nerve derived cell line
... the molecular events underlying the development of optic-nerve-derived oligodendrocytes and their growth-factor-related signal transduction events, we immortalized perinatal rat optic nerve cells ...
13
Molecular analysis of hepatitis B virus transmission events
... The core ORF has two in-phase initiation codons, pre-C and C, which encode the HBeAg and the core protein. Both share the same termination codon. The pre-core and core encode the precursor to HBeAg. Translation from the ...
268
STUDY OF TOTAL IGE LEVELS AND EOSINOPHIL COUNT ACCORDING TO AGE AND GENDER IN PATIENTS WITH ALLERGIC RHINITIS
... Allergic rhinitis is an acute IgE mediated type 1 hypersensitivity reaction of nasal mucosa in response to antigenic substances (allergens) associated with episodic attacks of sneezing, watery rhinorrhea and watering of ...
9
The role of glial cell line-derived neurotrophic factor signalling pathway in mammalian organogenesis
... The inducing factor(s) present in the embryonic spinal cord, the most potent tissue inducer o f nephron formation in vitro, has been shown to not be freely soluble (Herzlinger et al., 1994). This observation puts the wnt ...
182
Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes
... To determine the extent to which SoxB1 activity elicits the effect of FGF, we compared the genes downstream of Sox2 and Fgf4. Mitf and Otx2 encode transcription factors crucial for RPE fate specification (Bumsted and ...
11
Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Aluinsertion events
... Background: SP100 is a nuclear protein that displays a number of alternative splice variants. In Old World monkeys, apes and humans one of these variants is extended by a retroprocessed pseudogene, HMG1L3, whose ...
6
Positron Emission Tomography Reporter Genes and Reporter Probes: Gene and Cell Therapy Applications
... col. Early collaboration is also needed for optimizing the delivery of the PET IRG for the specific cell or gene therapy approach. Safe and stable PET reporter transgene delivery for clinical applications is a major ...
18
Ringel, Eva Rieke (2011): Molecular basis of RNA polymerase III transcription repression by Maf1 & Structure of human mitochondrial RNA polymerase. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... (a) Differences in topology of the ICs of T7, yeast and mammalian mitochondrial transcription machineries, based on foot- printing data and functional assays. Mammalian mitochondrial transcription critically depends on ...
111
Mal, more than a bridge to MyD88
... Because the production and secretion of mature IL-‐1β requires both TLR and inflammasome activation it has been postulated that TLR stimulation might directly regulate inflammasomes. However, there has been little ...
19