Molecular pathogenesis
The molecular pathogenesis of head and neck squamous cell carcinoma
... Squamous cell carcinoma of the head and neck (HNSCC) is a relatively common human cancer characterized by high morbidity, high mortality, and few therapeutic options outside of surgery, standard cytotoxic chemotherapy, ...
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Tropism and molecular pathogenesis of canine distemper virus
... inoculated through the nose or lung and that infection of the host through conjunctival administration, al- though less efficient, is also possible [41]. However, re- verse genetics is helpful not only to understand the ...
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Molecular pathogenesis of pulmonary arterial hypertension
... An increased understanding of PAH molecular pathogenesis leads to new therapeutic strategies to reverse PAH. A variety of new strategies have been developed to induce apoptosis of SMCs that have abnormally ...
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Investigation of the molecular pathogenesis of Kostmann's syndrome
... the molecular pathogenesis of cyclic neutropenia Schmitz and colleagues (1994) have proposed a model hypothesis to explain its origin based on a mathematical analysis of cell kinetic ...
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Molecular pathogenesis of human CD59 deficiency
... To evaluate deposition of MAC and cell lysis, we used in vitro cell lysis assays. Transfections of Chinese hamster ovary (CHO) cells were performed using Lipofectamine 2000 re- agent. Details appear in the supplementary ...
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Hemophilia B: Molecular pathogenesis and mutation analysis
... for Molecular Genetics of Heritable Bleeding Disorders, and arranges two surveys annually on the analysis of hemophilia A, hemophilia B, or von Willebrand disease ...
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Molecular pathogenesis and clinical management of Fanconi anemia
... The limitations of traditional gene therapy e.g., difficulty in isolating sufficient HSCs and the complications associated with bone marrow transplantation may be avoided by transplantin[r] ...
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Review Article Molecular pathogenesis of bacteria-induced periodontitis
... The pathogenesis of periodontitis arises essentially from a complex interplay between bacterial and host factors, leading to a range of presentations that depend on the balance of this ...the pathogenesis ...
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Lin28B, LET-7, and the Molecular Pathogenesis of Colon Cancer
... We thank the Veterinary Medical Scientist Training (V.M.D./Ph.D.) Program, The School of Veterinary Medicine, The School of Medicine in addition and the Cell and Molecular Biology Graduate group, all of which ...
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Molecular pathogenesis of multiple myeloma and its premalignant precursor
... It is thought that CCND translocations only dysregulate expres- sion of a CCND gene. In contrast, MAF translocations dysregulate expression of a MAF transcription factor that causes increased expression of many genes, ...
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Molecular pathogenesis of chronic lymphocytic leukemia
... Molecular knowledge of the CLL genotype has significantly advanced the understanding of the genetic basis of chemorefrac- toriness (Figure 2). TP53 disruption predicts treatment failure with many regimens and ...
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Molecular pathogenesis of the Sindbis-group virus strain AR86
... the pathogenesis of arthritogenic alphaviruses, improved animal models would be useful for dissecting the pathogenesis of these ...the pathogenesis of alphavirus-induced arthritis and ...the ...
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Current progress in understanding the molecular pathogenesis of burn scar contracture
... In the wound repair phase, contraction can close the original wound and reduce the surface area. However, the continuation of contraction after wound healing can have high clinical morbidity of the joint contractures, ...
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Studies on the genetics and molecular pathogenesis of mitochondrial respiratory chain disorders
... common mtDNA point mutations associated with Leber’s hereditary optic neuropathy (LHON).. and non-syndromic sensorineural deafness which are almost invariably virtually [r] ...
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Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis
... Broadly, TSAs arise via three mechanisms. They may be BRAF mutated and CpG island methylator phenotype (CIMP)-high: right sided, mediated through a microvesicular hyperplastic polyp or a sessile serrated adenoma, may ...
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Molecular pathogenesis of mantle cell lymphoma
... from molecular biology and pathology to the clinic, has improved the understanding of its pathogenesis and guides the search to design new therapeutic ...different molecular, genetic, and clinical ...
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Molecular pathogenesis of emphysema
... disease pathogenesis, as well as the role of the innate and adap- tive immune systems, are being explored in genetically altered animals and in exposure models of this ...and molecular events, including ...
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The molecular pathogenesis of feline calicivirus infection
... Several attempts have been made to identify markers of hypervirulent strains that could help explain the pathogenesis of this disorder, as well as act as a diagnostic marker for hypervirulence that could be used ...
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Molecular pathogenesis of sporadic colorectal cancers
... Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic ...
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The Molecular Pathogenesis Of Cerebral Cavernous Malformations
... the molecular mechanism of lesion formation will reveal relevant biomarkers (as well as potential therapeutic targets) that may be applicable to patients with regards to clinical trials as well as longitudinal ...
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