molecular signature
Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer
... Regardless of the specific changes found in each cell line, we searched for genes commonly associated to sen- sitivity to 17AAG. Analysis of differentially expressed genes between all treated compared with all untreated ...
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Competence for Chemical Reprogramming of Sexual Fate Correlates with an Intersexual Molecular Signature in Caenorhabditis elegans
... mixed molecular signature at both the RNA and protein ...intersexual signature was found in both of the reprogram- ming competent mutants (puf-8; lip-1 and fbf-1; lip-1), but not in either mutant ...
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Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front
... unique molecular signature that is consistent and stable over time in a subset of lead cells within the most advanced portion of the migratory front, which we term ...trailblazer molecular ...
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Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
... In the Bruneck study, associations of baseline ECM protein levels with early and advanced stages of atherosclerosis progression were analyzed by means of unconditional logistic regression analysis. The main analyses were ...
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Molecular Signature of Influenza A
... Conclusions Appearance of H1N1 in the human population was observed from the year 1918 based on the sequence information available from the NCBI database, Influenza A virus A/AFIP/1/1918[r] ...
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A molecular signature of dormancy in CD34+CD38 acute myeloid leukaemia cells
... Publically available data from the Cancer Genome Atlas (TCGA) [23, 24] on 149 cases of AML (excluding patients with a t(15;17) translocation, but comprising all other patients with documented outcome data) was studied to ...
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A candidate molecular signature associated with tamoxifen failure in primary breast cancer.
... expression signature and molecular markers associated with tamoxifen failure in breast ...Moreover, molecular markers encoding secreted proteins such as IGFBP4, which was validated in this study both ...
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Intrinsic molecular signature of breast cancer in a population based cohort of 412 patients
... intrinsic signature set of approximately 500 genes was originally selected on the basis of their stable expression between pairs of samples taken from the same tumors, before therapy and after 15 weeks of ...
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Molecular signature of selective microRNAs in Cyprinus carpio (Linnaeus 1758):a computational approach
... miRNAs are categorically related to the molecular mecha- nisms or actions of various clinical diseases. Which are po- tentially regulates many aspect of cellular and sub-cellular activities that might be included ...
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Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells
... The GO analysis was done at GO FAT level of biological process and molecular function, whereas Expression Analysis Systematic Explorer (EASE) biological theme analysis was carried out online (at http:// ...
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Unique molecular signature in mucolipidosis type IV microglia
... The microglial transcriptomic signature analysis of dis- ease state suggests a strong overlap between disease and aging. A subset (14%) of the shared modified genes in neurodegenerative disease and aging is ...
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A molecular signature in blood identifies early Parkinson’s disease
... Another major discovery of this investigation is that the PP values of the five-gene signature were accentuated in patients at late PD stage, suggesting a potential for the model to assess disease severity. One ...
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A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22
... correlates with the impaired induction of PTPN22 in PBMCs of ARIs. While the Th cytokine profile of ARIs is different from that of controls, the difference is modest overall. This is not surprising, given that all ARIs ...
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Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive prostate cancer cells
... Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene ...
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Molecular gene signature and prognosis of non–small cell lung cancer
... of molecular research may improve the management of ...The molecular signature can provide additional information for treatment ...the molecular status of the epidermal growth factor receptor ...
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Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes
... Similar to what was observed in the directly reprogrammed myotubes, DM1 cells displayed MBNL1 foci, a molecular signature of DM, while DM2 cells appeared similar to control, sug- gestin[r] ...
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Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2 5 function
... progenitors for ventricular and OFT lineages are specified medially in the heart forming region of the ALPM; 2 the molecular signature of zebrafish ALPM SHF progenitors is gata4+ this st[r] ...
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Identification of Biomarker Signatures and Candidate Drugs in Non-Small Cell Lung Cancer
... identify molecular to inform systemic drug targeting in ...discover molecular signature at RNA and protein levels which could serve as potential drug targets for therapeutics innovation and the ...
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Molecular characterization of papillary thyroid carcinoma: a potential three-lncRNA prognostic signature
... three-lncRNA signature, which proved to be a prognostic biomarker of ...lncRNA signature could largely predict the 5-year survival time (AUC = ...potential signature of PTC prognosis and ...
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HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia
... this signature was able to classify 3 independent cohorts of patients with AML from prospective clinical trials into groups with superior or significantly inferior ...epigenetic signature score reached ...
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