molecular targets
Molecular targets for tendon neoformation
... stabilization. Unfortunately, the almost acellular and collagen I–rich structure of tendons and ligaments makes them very poorly regenerating tissues. Injured tendons and ligaments are considered a major clinical ...
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Animal models and therapeutic molecular targets of cancer: utility and limitations
... Abstract: Cancer is the term used to describe over 100 diseases that share several common hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the second leading cause of death in the USA. ...
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Screening of potential molecular targets for colorectal cancer therapy
... To identify molecular targets for therapy, we conducted a study of RNAi-induced gene knockdown in HT-29 human colon cancer cells. The strategy for target identification is schematically shown in Figure 1. ...
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Molecular targets in arthritis and recent trends in nanotherapy
... new targets in arthritis therapy such as interleukin-1β, interleukin-17A, tumor necrosis factor alpha, osteopontin, and several others have been discussed here, which can lead to refinement of current therapeutic ...
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Molecular Targets of Dietary Polyphenols with Anti inflammatory Properties
... There is persuasive epidemiological and experimental evi- dence that dietary polyphenols have anti-inflammatory activity. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to combat ...
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Scientometrics of drug discovery efforts: pain-related molecular targets
... Abstract: The aim of this study was to make a scientometric assessment of drug discovery efforts centered on pain-related molecular targets. The following scientometric indices were used: the popularity ...
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INSILICO IDENTIFICATION OF MOLECULAR TARGETS FOR AJOENE [GARLIC COMPONENT] AND THEIR BINDING MODE ANALYSIS
... of molecular targets for chemicals derived from plant origin may help in understanding the therapeutic potential of many unknown ...novel targets for ajoene using ‘insilico reverse screening’ ...
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Identification of Possible Molecular Targets of Potential Anti-Alzheimer Drugs by Predicting their Binding Affinities Using Molecular Docking Technique
... The main purpose of this study is to identify the possible molecular target anti-Alzheimer’s drugs by studied them to target proteins (receptors). Various molecular targets were selected, i.e., 1W6R, ...
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IDENTIFICATION OF POSSIBLE MOLECULAR TARGETS OF POTENTIAL ANTI PARKINSON DRUGS BY PREDICTING THEIR BINDING AFFINITIES USING MOLECULAR DOCKING TECHNIQUE
... for molecular docking study. Results: Various molecular targets were selected (D2/D3, D2, A2A, and MAO-B) and studied for Pardoprunox, Istradefylline, Rasagiline, and ...
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Triply Differential Ionization Cross Sections of atomic and molecular targets by single electron impact
... The hydrogen atom represents the simplest case study that allows the validation of developed analytical and numerical models before moving on to molecular targets which intial state wave functions are more ...
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Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
... about molecular targets and detailed molecular events in the modulation of protein translation and the subsequent impact on proteostasis and cell sur- ...
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The selection of aptamers specific for membrane molecular targets
... membrane molecular targets, due to various challenges, while there are hundreds of reports of selections for non-membrane molecular ...membrane targets are worth the extra effort because of ...
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New molecular targets against cervical cancer
... incorporating molecular-targeted therapy as radiosensitizers are in progress, so far, only antiangiogenic therapy with bevacizumab added to cisplatin chemoradiation has demonstrated safety and shown encouraging ...
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Molecular targets in urothelial cancer: detection, treatment, and animal models of bladder cancer
... 177. Knapp DW, Ramos-Vara JA, Moore GE, Dhawan D, Bonney PL, Young KE. Urinary bladder cancer in dogs, a naturally occurring model for cancer biology and drug development. ILAR J. 2014;55(1):100–118. 178. Dill AL, ...
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Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies
... nucleotide sequence but influence gene regulation and expression [77]. Changes involving gene expression control through epigenetic modifications are increas- ingly recognized as major mechanisms involved in the ...
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Predicting new molecular targets for known drugs.pdf
... Author Contributions B.K.S., J.J.I. and M.J.K. developed the ideas for SEA. M.J.K. wrote the SEA algorithms, undertook the calculations, and identified the off-targets reported here, typically vetted with J.J.I. ...
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Identification of molecular targets of potential antidiabetic drugs using prediction of activity spectra for substances and molecular docking
... Based on PASS prediction five phytoconstituents were selected for molecular docking study using AutoDock Vina 4.0. Three target sites which were DPP-4, GLP-1, and α glucosidase, perhaps were selected for ...
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Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview
... With recent advances in the knowledge of hepato-car- cinogenesis, there has been encouraging development in the systemic therapy of advanced HCC patients, and particularly in the therapy based on specific targets ...
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Valproic Acid, a Drug with Multiple Molecular Targets Related to Its Potential Neuroprotective Action
... VA also has a role in the chromatin structure by altering gene expression and affecting other signaling systems, such as pathways regulated by Wnt/β-catenin (Wnt be- longs to a family of secreted glycolipoproteins and, ...
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NEW INSIGHTS INTO MOLECULAR TARGETS FOR DEPRESSION
... and molecular alterations localized to a complex network of neural ...novel targets for ...Monoamine, Molecular target, Corticotropin-releasing ...
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