Molecular testing
Molecular testing in oncology: Problems, pitfalls and progress
... the molecular basis of cancer have lead to the development of targeted therapies, such as trastuzumab for the treatment of HER-2 overexpressing metastatic breast cancer [2] and imatinib for the treatment of ...
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The Drift in Molecular Testing for Influenza: Mutations Affecting Assay Performance
... Currently, molecular-method- based influenza tests are regulated by the FDA (“Guidance for Industry and FDA Staff—Class II Special Controls Guidance Document: Respiratory Viral Panel Multiplex Nucleic Acid Assay”; ...
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Point Counterpoint: Molecular Testing for Infectious Diseases Should Be Done in the Clinical Microbiology Laboratory
... FDA-cleared molecular diagnostic test platforms available for the detection of microorganisms that represent simple, sample-in, answer-out systems with tests of moderate to low complexity (Cepheid, Idaho ...
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Role of molecular testing in the multidisciplinary diagnostic approach of ichthyosis
... We report our experience on a cohort of patients using a NGS approach on the Illumina MiSeq platform. The preparation of the genomic library using the TSCA Illumina kit was completed in two working days. Two days were ...
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Molecular testing for adult type Alport syndrome
... This assay is designed to detect mutations responsible for the majority of adult type AS in the US. It is recommended for diagnostic, pre-symptomatic, or carrier testing of indi- viduals from families known to ...
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FISH molecular testing in cytological preparations from solid tumors
... tumor molecular cytogenetics impact classical and molecular ...of molecular cytogenetics into cytology in spite of the remarkable promiscuity of cancer ...
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Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug resistant tuberculosis in South Africa
... of molecular assays may be considered in some ...standard testing on all ...if molecular testing were used as a rapid alternative to conventional indirect phenotypic ...
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Personalized therapy for lung cancer: striking a moving target
... 1). Molecular testing, often by next-gener- ation sequencing (NGS), is routinely used at the time of diagnosis to determine the best treatment approach for a given ...
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Streptococcus Toxic Shock Syndrome Due to Non Haemolytic Streptococcus pyogenes
... Case Presentation: We present the case of a 36-year-old Peruvian male who presented to the Emergency Department with a 24-hour history of fever, nausea, vomits and diarrhea. He received intravenous hydration and ...
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Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel
... multiplex molecular testing for CNS pathogens in young infants, there were a limited number of positive detections, and sample sizes were too small for statistical ...of molecular testing on ...
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The Molecular Genetics Testing Lab. On the Fringe of Personhood
... however, molecular testing primarily supports diagnosis accuracy and corresponding gender ...the molecular testing has had the unexpected repercussion of diminishing irreversible ...
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Evaluation of a Multiplex Real Time PCR Assay for Detecting Major Bacterial Enteric Pathogens in Fecal Specimens: Intestinal Inflammation and Bacterial Load Are Correlated in Campylobacter Infections
... In a previous study, C. jejuni/C. coli were the most frequently detected pathogens, similar to the results of our study (4). We observed an overall prevalence of 13.5% for C. jejuni/C. coli, Sal- monella spp., and ...
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Molecular Diagnostic Testing for Aspergillus
... Molecular testing for IA has been deployed as either a standalone test for at-risk patients with compatible signs/symptoms or a part of screening ...once-weekly testing continued until day 90 ...
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Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat
... Molecular testing performed on other specimens may extend the window of YFV RNA ...but testing of this specimen is warranted in suspected ...by molecular methods in early severe YF cases that ...
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Point Counterpoint: The Automated Clinical Microbiology Laboratory: Fact or Fantasy?
... Conclusions. Good microbiologists are indeed hard to find, but positive efforts are being made to train them. Automation is not the only solution for staffing shortages in microbiology. Effi- ciency can be enhanced ...
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Molecular Detection of Resistance Determinants
... of molecular antimicrobial susceptibility assays have focused primarily on Gram-positive pathogens while forgoing the more complex issues inherent to pathogenic Gram-negative ...
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Silver-Russell syndrome: genetic basis and molecular genetic testing
... that copy number variation and aberrant methylation at different loci in 11p15 can be detected in one tube. Thus, methylation defects at both ICRs in 11p15 as well as duplications and UPDs of this region will be identi- ...
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Bayesian molecular phylogenetics: estimation of divergence dates and hypothesis testing
... likelihood ratio tests and marginal distributions for evolutionary tree models with. constraints on parameters[r] ...
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Evaluation of the Bruker Biotyper and Vitek MS Matrix Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Systems for Identification of Nonfermenting Gram Negative Bacilli Isolated from Cultures from Cystic Fibrosis Patients
... Distinguishing among NFGNB using manual and automated commercial identification systems is often challenging due to lim- ited biochemical reactivity (15). The molecular methods required for accurate identification ...
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Molecular Identification and Antifungal Susceptibility Testing of Clinical Isolates of the Candida rugosa Species Complex and Proposal of the New Species Candida neorugosa
... While there are no data on the in vitro antifungal susceptibility of C. pseudorugosa and C. pararugosa, several in vitro susceptibility studies have reported reduced susceptibility of C. rugosa to AMB (6, 7), FLC and VRC ...
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