MOLT-4
Radio-Sensitization of Human Leukaemic MOLT-4 Cells by DNA-Dependent Protein Kinase Inhibitor, NU7026
... iR is commonly used in cancer treatment in order to eliminate tumour cells by apoptosis. a wide range of kinase inhibitors is used intentionally to increase the cytotoxic effect of radiation. in our previous work, we ...
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Cytotoxic effect of Pregabalin on U937 and Molt-4 Leukemic Cells in Vitro
... and Molt-4 ...and Molt-4 cells after 24 hours ...on Molt-4 cells was observed at 1000, ≥ 500 and ≥ 1 μg/ml concentrations of drug after 24, 48 and 72 hours treatment, ...and ...
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Green synthesis palladium nanoparticles mediated by white tea (<em>Camellia sinensis</em>) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
... Abstract: Among nanoparticles used for medical applications, palladium nanoparticles (PdNPs) are among the least investigated. This study was undertaken to develop PdNPs by green synthesis using white tea (W.tea; ...
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Ionizing Radiation Sensitizes Leukemic MOLT-4 Cells to TRAIL-induced Apoptosis
... leukemia MOLT-4 are resistant to TRAIL and that ionizing radiation in the therapeutically achievable dose of 1 Gy sensitizes TRAIL-resistant cells MOLT-4 to the TRAIL-induced apoptosis by ...
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The Synthetic Peptide P-197 Inhibits Human T-Cell Leukemia Virus Type 1 Envelope-Mediated Syncytium Formation by a Mechanism That Is Independent of Hsc70
... P-197 inhibits HTLV-1 syncytium formation among diverse target cell populations. To examine the inhibitory properties of the SU-derived peptides, the control peptide P-80, the in- hibitory peptide P-197, or solvent only ...
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Original Article A novel TAL1/miR-149 axis accelerates tumor growth of human T cell acute lymphoblastic leukemia
... in Molt-4 cells are the highest among the four tumor cell ...while Molt-4 cells were selected to transfect with TAL1 knockdown plasmid for the following ...
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Eliminating malignant contamination from therapeutic human spermatogonial stem cells
... SSCs may have application for preserving and restoring sperma- togenesis in men who are rendered infertile due to chemother- apy or radiation treatment for cancer or other conditions. A boy or man could theoretically ...
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Depletion of glycoprotein gp85 from virosomes made with Epstein-Barr virus proteins abolishes their ability to fuse with virus receptor-bearing cells.
... The failure of virosomes bound to Molt 4 cells or to fixed Raji cells to demonstrate any relief of self-quenching of R18 was of particular importance, as it confirmed that dequenching wa[r] ...
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Cytotoxicity of Metoprolol on Leukemic Cells in Vitro
... and MOLT-4 cells was ...and MOLT-4 cells after 48h incubation ...on MOLT-4 cells was shown at 1000 and ≥100µg/ml concentrations of drug after 48 and 72h incubation, ...(72h), ...
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Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor.
... Viruses obtained from treated and untreated cultures were called the escape and passaged viruses, respectively, and were used to infect MOLT-4 cells to establish chronically infected pro[r] ...
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Antibody dependent complement mediated cytotoxicity in sera from patients with HIV 1 infection is controlled by CD55 and CD59
... 6, Molt-4 and CEM cells data not shown expressing CD55 and CD59 were used as targets for antibody-dependent complement-mediated cytotoxicity, no significant lysis was observed compared w[r] ...
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Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics
... in Molt-4 cells, whereas it activated the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathway in Jurkat and CEM-R cells as protective mechanisms in a sub-population of T-ALL ...
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Substance P recognition by a subset of human T lymphocytes
... Purified human blood B-lymphocytes, monocytes, polymorphonuclear leukocytes, and platelets, and cultured Hut 78 cutaneous lymphoma T-cells, Jurkat cells, Molt-4 lymphoblasts, and HL-60 a[r] ...
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Characterization of Hepatitis C Virus (HCV) and HCV E2 Interactions with CD81 and the Low-Density Lipoprotein Receptor
... to MOLT-4 cells, pelleted virus or the corresponding pellet from HCV-negative plasma fractions (Mock) were added to MOLT-4 T cells and virus was identified using human HCV antiserum followed ...
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Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2
... derivative, which is unable to bind Molt-4 cells or isolated recombinant CD81 but still interacts with hepatoma cells, al- beit less efficiently than the wt protein. The ability of this mutant to interact ...
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Novel Reporter T Cell Line Highly Susceptible to Both CCR5 and CXCR4 Using Human Immunodeficiency Virus Type 1 and Its Application to Drug Susceptibility Tests
... CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) is a major viral population that is trans- mitted by sexual intercourse and that replicates in infected individuals during the asymptomatic stage of HIV-1 ...
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Cytocidal effect of tumor necrosis factor on cells chronically infected with human immunodeficiency virus (HIV): enhancement of HIV replication.
... The viability of human T-cell line MOLT-4/HIV, chronically infected with HIV, was affected by the addition of a low dose 10 ng/ml of recombinant TNF-a rTNF-t, while uninfected MOLT-4 cel[r] ...
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RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death
... To clarify the role of lipid peroxidation in RSL3/BV6- or Erastin/BV6-induced cell death we ectopically expressed GPX4, which is described to protect biomembranes from oxidative stress by specifically reducing lipid ...
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Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.
... Virion infectivity factor (vif), a gene found in all lentiviruses, plays an essential role in virus replication in certain target cells. We examined the replication competence of the human immunodeficiency virus type 2 ...
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ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts
... fold change was greater than or less than 1.25, compared with that of the cells transfected with control-siRNA. Based on these criteria, 131 genes were selected as the genes commonly down-regulated by depletion of ZFAT ...
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