Monoclonal gammopathies
Iodine-based contrast media, multiple myeloma and monoclonal gammopathies: literature review and ESUR Contrast Media Safety Committee guidelines
... A systematic search in Medline and Scopus databases was performed for studies of renal function deterioration in pa- tients with MM or MG after administration of iodine-based contrast media. The search strategy was peer ...
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Differences in genomic abnormalities among African individuals with monoclonal gammopathies using calculated ancestry
... MM, although considered a single disease, can be divi- ded into different cytogenetically de fi ned subtypes with differences in disease outcome. Cytogenetic subtypes include hyperdiploidy (characterized by gains of odd- ...
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Relationship between circulating syndecan-1 levels (CD138s) and serum free light chains in monoclonal gammopathies
... could represent a valuable tool to be used alongside with FLCs quantification during follow-up and monitoring of myeloma affected subjects undergoing treatments. This could be done in order to investigate how different ...
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Antigen-mediated regulation in monoclonal gammopathies and myeloma
... GD-associated monoclonal gammopathy originates as part of a polyclonal response against antigenic lipids, and emergence of monoclonal PCs is associated with suppression of antigenically related nonclonal ...
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Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation
... These results show that, generally, serum IGF-I concentra- tions behave similarly to the monoclonal component. Some of the divergences observed may be explained by the fact that various eveniences may influence ...
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Central and peripheral neurological involvement in monoclonal gammopathies of undetermined significance
... The case of the young man with cerebellar atrophy shows that he suffered progressive cerebellar syndrome, first unilaterally, then bilaterally. A serial MRI showed only cerebellar vermis atrophy. A CSF exam showed ...
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Characterisation of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival in both old and recent myeloma trials
... trials. To our knowledge, this is the fi rst study of this nature in a large cohort of patients enroled in national clinical trials. Findings exposed a notably high incidence of immunoparesis at diagnosis, where, in 80% ...
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Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature
... and monoclonal gammopathies ...of monoclonal immunoglobulins or frag- ments thereof (M protein) can be found in pre-malignant conditions such as MGUS (monoclonal gammopathy of undetermined ...
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<p>Essential Thrombocythaemia with Concomitant Waldenström Macroglobulinaemia: Case Report and Literature Review</p>
... Essential thrombocythaemia (ET) is one of the myeloproliferative neoplasms (MPNs). Waldenström macroglobulinaemia (WM) is a lymphoplasmacytic lym- phoma with an IgM monoclonal gammopathy and bone marrow ...
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Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders
... of monoclonal gammopathies can be broadly categorised into three main topics (Table 1): (i) primary diagnosis of myeloma and associated disorders, based on the enumeration of plasma cells in the bone marrow ...
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Immunological evidence of monoclonal gammopathy in North India: a hospital based study
... Biochemical and immunological investigations have gained tremendous importance over years to help in establishing the diagnosis of diseases. Clinical laboratories play an important role in the study of monoclonal ...
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Simultaneous occurrence of fibrillary glomerulonephritis and renal lesions in nonmalignant monoclonal IgM gammopathy
... We performed immunofluorescence studies, observing a strong positive staining for IgM with a diffuse, global, granular, and capillary pattern (Fig. 2a) ; positive staining for IgG with a diffuse, granular, and mesangial ...
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Characterization of Aeromonas trota strains that cross react with Vibrio cholerae O139 Bengal
... two monoclonal antibodies specific for ...the monoclonal antibodies did not result in a diagnosis of ...the monoclonal antibodies are directed is absent from ...
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Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells.
... Epitope mapping of monoclonal antibodies against human immunodeficiency virus type 1 structural proteins by using peptides.. Monoclonal antibodies directed against human immunodeficiency[r] ...
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Questions About Palivizumab (Synagis)
... humanized monoclonal antibody designed for the preven- tion of serious disease attributable to respiratory syncytial virus (RSV) has recently been approved by the Food and Drug Admin- istration ...
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Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1.
... We report that all 10 monoclonal antibodies reacted with epitopes contained in the N-terminal 288 amino acids of the protein, that the epitope of one of the blocking monoclonal antibodie[r] ...
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Detection of experimental Chlamydia trachomatis eye infection in conjunctival smears and in tissue culture by use of fluorescein conjugated monoclonal antibody
... Frequency of positive detection of chlamydial infection by four different methods monoclonal antibody-stained cytology, monoclonal antibody-stained tissue culture, iodine-stained tissue [r] ...
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Antigenically variable Borrelia burgdorferi isolated from cottontail rabbits and Ixodes dentatus in rural and urban areas
... While the rabbit isolate reacted with two preparations of monoclonal antibodies, the tick isolates bound to one or all three of the monoclonal antibodies tested.. The cultures from rabbi[r] ...
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Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10
... promote monoclonal antibody recognition of Chla- mydia-specific epitopes within chsp10, four-branch multiple-antigen peptides (MAPs) (46, 47) were used as immunogens ...
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Monoclonal immunoglobulin mediates complement activation in monoclonal gammopathy associated-C3 glomerulonephritis
... a monoclonal IgG λ ...a monoclonal IgG λ , and could inhibit CFH binding to C3b and accelerate the formation of C3 convertase indirectly by interfering with the formation-impeding activity of ...of ...
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