mouse brain endothelial cells
Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells
... PPCSE has been shown to induce the expression of inflammatory proteins associated with various inflamma- tory responses [25,26]. NADPH oxidase is an important enzymatic source for the production of ROS under var- ious ...
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Semliki Forest virus infects mouse brain endothelial cells and causes blood-brain barrier damage.
... BBB damage or increased expression of adhesion molecules caused by the virus infection could be possible mechanisms of the observed association, since vascular permeability changes are a[r] ...
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Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells
... CoPP were reversed by ZnPP. To further confirm the effect of HO-1 overexpression induced by CoPP on LPS-mediated responses, bEnd.3 cells were transfected with either adenovirus or recombinant adenovirus carry- ing ...
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Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells
... hepatotropic mouse hepatitis virus type 3 (MHV3), its attenuated variant, ...for endothelial cells, and the weakly hepatotropic MHV-A59 strain from the murine coronavirus group, we investigated the ...
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Endothelial LRP1 transports amyloid β1–42 across the blood brain barrier
... affecting brain clearance of toxins such as Aβ, providing further evidence for the impor- tance of cerebrovasculature function in the healthy brain (2, ...Aβ brain levels and the initi- ation and ...
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Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2
... PAR-2. Mouse brain microvascular endothelial cell were pre-treated with FS at 400 μ M for 30 min and then stimulated with tryptase at 1 μ g/mL for 24 ...The cells were stained with anti-VCAM-1 ...
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Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro
... Porcine endothelial and rat glial cells have been shown to be a useful system for contact-dependent BBB studies ...rat cells might thus be able initiate modulating signals despite species ...
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Mouse Adenovirus Type 1-Induced Breakdown of the Blood-Brain Barrier
... in brain endothelial cells (65, 67, ...of brain endothelial cells ...a mouse model causes breakdown of the BBB mediated by Toll-like receptor 3 and tumor necro- sis factor ...
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Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells
... cancer brain metastases and WP1066 inhibited brain ...cancer brain metastasis specimens. ***, P<0.001. (C) MDA-MB-231BR cells and BT-474BR cells were treated with 1 μM WP1066 (wp) ...
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Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
... between mouse and human ECs, let us to interpret the matching genes as being the most important, obtaining 5 significantly regu- lated genes (Table ...of endothelial cells, that are sensitized to ...
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The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
... porcine brain endothelial ...other cells of the neurovas- cular unit in a complex 3D model, to give more reliable modelling of the in vivo ...these cells by the suppliers and thereby used by ...
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Regulation of the bone vascular network is sexually dimorphic
... Figure 5. Direct effects of VEGF deletion on male and female osteoblast function. VEGF was deleted in vitro in male and female LOBs (P4). No differences in viability (ATP; a) versus WT were evident from males or females. ...
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia
... Materials and Methods: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC).. in vitro and cryostat s[r] ...
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15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases
... downregulating endothelial CAMs expression, thereby giving a significant additive effect on inhibition on adhe- sion of ...of endothelial CAMs under our experimental ...in brain glial cells ...
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Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells
... and 10 of subculture, a value equivalent to the maximum TEER achieved after initial induction of BMEC pheno- type. Finally, SM14 iPSCs, which harbor biallelic loss-of- function PARK2 mutations associated with familial ...
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Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat
... Brain sections embedded in OCT and cut on a cryostat (10 μm) were prepared for either occludin or claudin-5, and von Willebrand factor (vWF) double immunofluor- escence, or IL-1β. Brain sections were ...
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HIV 1 associated dementia: symptoms and causes
... these cells into the CNS are discussed in the next ...human cells, CXCR4 appears to be the most important for HIV-1 entry into lymphocytes and CCR5 for monocytes, macro- phages and microglia ...infected ...
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A2A adenosine receptor modulates drug efflux transporter P glycoprotein at the blood brain barrier
... primary cells, we next examined the effect of Lexiscan and NECA treatment on P-gp expression in primary human brain endothe- lial ...primary brain endothelial cells similar to those ...
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The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144
... Blood-tumor barrier (BTB) limits the delivery of chemotherapeutic agent to brain tumor tissues. Long non-coding RNAs (lncRNAs) have been shown to play critical regulatory roles in various biologic processes of ...
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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit
... Whole brain lysates from mice treated with the three-injection regimen of LPS described above were gently homogenized in 150 μl of NP40 buffer (Invi- trogen, Grand Island, ...whole brain lysates using a ...
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