Mouse melanoma
In Vivo Anticancer Activity of the Leaves and Fruits of Moringa Oleifera on Mouse Melanoma
... Fruit and leaves are having a number of different phytoconstituents, which reflects that a particular single constituent may not be responsible for antitumor effect, but this effect was resulted from combined effect or ...
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Inhibitory Effect of Cigarette Smoke Extract on Experimental Lung Metastasis of Mouse Melanoma by Suppressing Tumor Invasion
... We investigated the effect of a nicotine- and tar-free cigarette smoke extract (CSE) using an experimental metastasis mouse model which was intravenously injected with B16-BL6 mouse melanoma cells. ...
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Inhibition by Tyroserleutide (YSL) on the Invasion and Adhesion of the Mouse Melanoma Cell
... There are many reports on the bell- shaped dose-effect curve, such as 5-HT3 receptor inhibitor–tropisetron (25) and al- licin (the main organic allyl sulfur com- ponent in garlic) (26). Curnis et al. (27) showed that ...
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Annona muricata L. extracts decrease melanogenesis in B16F10 mouse melanoma cells
... After cell treatments, culture media were removed and the cells were washed twice in ice-cold PBS (pH 7.4) and then incubated on ice for 20 min in a radioimmunopreci- pitation assay buffer (Sigma-Aldrich, USA) containing ...
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Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
... Previous studies have shown that Rho pathway com- ponents are potential therapeutic targets for tumor pro- gression and metastasis [43]. Farina et al. have reported that lovastatin inhibits Rho isoprenylation, migration, ...
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Novel 89Zr cell labeling approach for PET-based cell trafficking studies
... In this study, we propose a novel cell labeling strategy that covalently binds a 89 Zr-DFO-labeled agent to cell surface proteins independent of cell type. The novel method employs the two-step process (Figure 1): 1) ...
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Differential AKT dependency displayed by mouse models of BRAFV600E initiated melanoma
... or mouse melanoma cell lines described above were treated with a range of concentrations of BKM-120 (from 0–5 μM) or with LGX- 818 (from 0–10 μM) either alone or in combination to assess possible ...
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Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis
... of mouse melanoma cell lines defined as weakly metastatic, and their highly meta- static ...in mouse melanoma ...metastatic melanoma cells to metastasise in vivo, a phenotype that could ...
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Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid
... and mouse melanoma cell lines induced cell cycle arrest by increasing p21 transcription and restored sensitivity to RA by downregulating expression of PRAME, a melanoma ...in melanoma cell ...
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Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice
... administering a VEGF inhibitor and then withdrawing treatment to allow VEGF levels to rebound in mice harboring mouse melanoma cells expressing VEGF 165 allows tumor- associated endothelial cells ...
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Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme
... Antiangiogenesis is a promising antitumor strategy that inhibits tumor vascular formation to suppress tumor growth. DNAzymes are synthetic single-strand deoxyribonucleic acid (DNA) molecules that can cleave ribonucleic ...
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Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo
... The main goal of this study was to assess the role of perle- can in two well-studied cellular systems, i.e., human colon car- cinoma and mouse melanoma cells. We generated stably trans- fected clones of ...
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Orally administered endoxifen inhibits tumor growth in melanoma-bearing mice
... With the growth in understanding of the importance of cytochrome P450 2D6 (CYP2D6) polymorphism and its relationship with the therapeutic outcome of tamoxi- fen in patients with breast cancer [6], we can now partly ...
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RAC1(P29S) Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance
... TCGA melanoma cohort, with or without BRAF mut , RAC1 P29S/L mutation, or RAC1 overex- pression is also associated with relapse (Figures 7F and ...S7J). Mouse melanoma cell cultures with RAC1 P29S ...
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Histological evaluation of intratumoral myxoma virus treatment in an immunocompetent mouse model of melanoma
... Figure 8 Neutrophil infiltrates in and around melanoma tumors. (A) Histopathology of representative tumor sections at the indicated time points after intratumoral treatment (hematoxylin and eosin, 400×). Tumors ...
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Exoresection via partial lamellar sclerouvectomy approach for uveal tumors: A successful performance by a novice surgeon
... in 1 patient (4.5%). All patients with cataract underwent phacoemulsification surgery with intraocular lens implan- tation (IOL) (Figure 1c). In one case (4.5%), nucleus drop during phacoemulsification surgery occurred, ...
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Chemopreventive Action of Lawsonia Inermis Leaf Extract on DMBA-Induced Skin Papilloma and B16F10 Melanoma Tumour
... This is suggestive of kerating squamous cell carcinoma grade II. When the L. inermis extract was applied along with the DMBA and Croton oil malignant tumours were not seen as compared to DMBA + Croton oil group. In the ...
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Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth
... C32 melanoma cells in culture visualized by confocal ...C32 melanoma cell reconstruction using the T3D package in ...C32 melanoma cells were treated with the indicated concentration of melittin on α ...
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Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
... full width at half maximum in the center of the field of view and 3 mm at 4 cm radial offset. Each mouse was subjected to a 15-minute acquisition. During imaging, mice were placed in an imaging chamber and ...
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Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model
... of melanoma tumor in the C57 / Black mice that received live protosculex was significantly smaller than that of control group ...the melanoma tumor size of mice that had been immunized with cyst fluid and ...
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