Mouse Retina
Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies
... MT1-MMP expression in the healthy, adult mouse retina MT1-MMP is a very complex MMP to investigate. Not only does this MMP occur in its membrane-bound form, it also undergoes autocatalytic and ...
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Rod and cone contributions to horizontal cell light responses in the mouse retina
... transgenic mouse lines to examine the contributions of rod and cone photoreceptor inputs to horizontal cell light responses in the mouse retina: rod signals were isolated by recording intracellularly ...
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Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina
... embryonic retina (Bovolenta et ...albino retina, which may reflect the quantitative differences in cell production described ...albino mouse retina To evaluate quantitatively differences in ...
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Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina
... the mouse retina provides an attrac- tive model system for exploring the mechanisms of angiogenesis and vascular stabilization (17, ...the retina neuronal and astrocytic ...pathological retina ...
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Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
... vertebrate retina, the six major neuronal cell types and one type of Müller glia are arranged in a well-defined laminar ...in mouse retina based on their synaptic inputs from rod or cone ...
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Separation of photoreceptor cell compartments in mouse retina for protein analysis
... live retina and adhesive tape peeling of lyophi- lized retina offer a rapid, reproducible alternative means for separating layers of the mouse retina for subsequent biochemical ...
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Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina
... Using a novel Ptf1a-Cre knock-in mutation in combination with a ROSA26 reporter transgene, we could analyze the expression of Ptf1a in the mouse retina. The experiments reported here show that Ptf1a ...
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Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina
... Our data support the idea that Notch signaling is a component of neuronal wavefront propagation (Fig. 8). There is precedent in vertebrates for Notch ligand-mediated coordination of neurogenesis among subsets of cells, ...
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Non-viral siRNA delivery into the mouse retina in vivo
... In this work we explored Transit-TKO transfection reagent as a carrier to deliver siRNA into the mouse retina in vivo through intravitreal injection. As a base protocol for Transit-TKO/siRNA formulation we ...
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Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling
... the mouse, a genetic reporter under the control of β-Catenin/TCF/LEF response ele- ments showed WNT activity to be concentrated to the CM [6], and specific ablation of Ctnnb1 in OC progenitor cells (OCPCs) reduced ...
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Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
... Consistent with the notion that reactive microglia can provide protection against excitotoxic damage, we found that treating retinas with IL1β prior to injury leads to a de- crease in cell death and an increase in ...
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Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma
... the retina and optic nerve (3, 20–22, 43, ...the retina, largely preventing the thinning of the nuclear and plexiform layers and the reactive gliosis linked to over- all structural ...
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Notch1 functions to suppress cone photoreceptor fate specification in the developing mouse retina
... Notch1 activity has been implicated in the inhibition of ganglion cell fate. This is based on the observation that ganglion cell production increases following antisense treatment of chick retinas with CNotch-1 or its ...
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Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina
... Functional classification and pathway analysis. The DEPs of all combinations were uploaded to the DAVID annotation tool using the complete mouse proteome as background. The GO terms were predicted based on ...
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Standard anatomical and visual space for the mouse retina : computational reconstruction and transformation of flattened retinae with the Retistruct package
... quasi-spherical retina into a 2D ...adult retina to within 8 u of arc ...adult mouse visual system. We orient the retina relative to the nictitating membrane and compare this to eye muscle ...
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Death by color: differential cone loss in the aging mouse retina
... the retina, 30% of rod photoreceptors are lost over life in humans and ...in mouse cone photoreceptors, which is surprising because cone physiological func- tion declines with ...ventral retina and ...
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Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis
... comprehensive ophthalmic evaluation of mice lacking CYP27A1. We found that the loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected upregulation of retinal cholesterol ...
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Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers
... In contralateral eyes and OHT eyes the two morpho- logical types of Iba-1+ cells described above showed a re- traction of the cellular processes in comparison with naïve eyes (Figures 3B,C, 4C-H). In addition, scarce ...
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Factors influencing rod photoreceptor differentiation in the mouse retina: a focus on insulin like growth factor 1
... the retina is the retinal ganglion ...the retina are the horizontal and amacrine ...the retina is the Müller ...the retina form the inner limiting ...
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Cone opsin mislocalization in Rpe65 / mice: A defect that can be corrected by 11 cis retinal
... ⫺/⫺ mouse retinas are local- ized almost exclusively in the peripheral retina at P25, the analyses for all animals was restricted to those ...wt mouse retina ...
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