Mouse xenograft
Analysis of the anti tumor effect of cetuximab using protein kinetics and mouse xenograft models
... the mouse xenograft Treatment with 6 injection of cetuximab for 26 days resulted in a significant suppression of tumor growth (P < ...the xenograft tumor ...
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Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
... The major organs and tissues collected were whole blood, brain, skin, heart, lung, liver, spleen, kidney, bladder, muscle, and tumor. The time points of data collection were at hours 0, 0.5, 1, 6, 16, 24, 48, and 72. At ...
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Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model
... Kidney damages in MM patients are often manifested by increase in protein contents in urine and in the levels of serum free light chains (FLCs), calcium and IL-6 in serum [17–20]. To analyze the effect of McAb- PTX-NPs ...
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Resolution of psoriasis upon blockade of IL 15 biological activity in a xenograft mouse model
... Patients used for SCID mouse xenograft model. All patients had moderate to severe plaque psoriasis. The duration of disease was 21 to 43 years. None of the patients received any systemic treatment or pho- ...
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Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model
... A mouse xenograft model with two large peritoneal implants of colorectal cancer cells was developed to study drug distribution and tumor physiology during intraperitoneal Oxaliplatin ...
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The effects of ponatinib, a multi-targeted tyrosine kinase inhibitor, against human U87 malignant glioblastoma cells
... Abstract: Glioblastoma is one of the most common malignant tumors in the nervous system in both adult and pediatric patients. Studies suggest that abnormal activation of receptor tyrosine kinases contributes to ...
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Activated platelets inhibit hepatocellular carcinoma cell differentiation and promote tumor progression via platelet-tumor cell binding
... or mouse xenograft tumors were cut at a thickness of 5 μm and then mounted on coated microscope ...A mouse IgG isotype control antibody (Jackson ImmunoResearch) was used at the same concentration as ...
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FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... FGF2 treatment increased horizontal and vertical migration and F-actin cytoskeleton assembly, decreased adhesive activity of MUM2B UM cells, together with promotion of metastasis in a mouse xenograft model. ...
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FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma
... 25, 26, 35]. In this study, we observed that the expression of phosphorylated AKT and ERK in FGF4-stimulated cells were not increased compared with control cells. On the other hand, FGF4 treatment remarkably upregulated ...
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Embryonic zebrafish xenograft assay of human cancer metastasis
... in mouse xenograft models as large numbers of patient primary tumour cells are required for successful ...zebrafish xenograft assay is the capacity to accurately detect and monitor a small number of ...
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Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD deficient adenovirus in gastric cancer cells
... Gastric cancer (GC) is the second-most frequent cause of cancer-related death worldwide [3]. In most cases of GC, the p53 pathway is not functional due to the high frequency of p53 gene mutation or the loss of p14 ARF ...
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Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
... each mouse was anesthetized using isoflurane/oxygen gas from a vaporizer and placed face-up on a height-adjustable tray in the imaging system for whole body ...
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Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma
... on mouse models Flow cytometry, hematoxylin and eosin (H&E), and immu- nohistochemistry (IHC) staining were applied to evaluate the cytotoxic activities and tissue distribution of ...
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High dietary level of synthetic vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue
... such sites are known (preventing recognition of the assay to any potential contaminating genomic DNA). Standard RNA was made for all assays by the T7 polymerase meth- od (Ambion, Austin, TX), using total RNA isolated ...
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Original Article The role of PET imaging probes for early monitoring the response to tamoxifen therapy in a xenograft nude mouse model of ER-positive breast cancer: comparison of 18 F-FDG, 18 F-FES, and 18 F-FLT
... the response to tamoxifen treatment as early as 3 days in breast cancer with a mouse xeno- graft model of ER+ breast cancer. Additionally, immunohistochemical (IHC) analyses of ERα, ERβ, glucose transporter type 1 ...
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Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
... Figure 7: Apatinib suppressed anti-apoptotic cell growth in ICC cells. a. Apatinib treatment promoted apoptotic cell death in RBE and SSP25 cells. Cell apoptosis was determined by Annexin V-Flow cytometry method and ...
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Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells
... Total proteins were isolated from cells with RIPA lysis buffer (Biosharp, Hefei, China) and the concentrations were determined with a BCA detection kit (Beyotime, Shanghai, China). Total protein (50 μg) was separated in ...
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Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model
... vivo xenograft mouse model, and suppressed both COX-2 and Ki-67 expression To confirm radiosensitizing effect of diclofenac in vivo, we conducted animal experiments using xenograft mouse model ...
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Oncolytic Herpes Simplex Virus 1 Encoding 15-Prostaglandin Dehydrogenase Mitigates Immune Suppression and Reduces Ectopic Primary and Metastatic Breast Cancer in Mice
... metastases (25). To determine the abilities of OSV and OSVP viruses to inhibit development of tumor metastasis, pulmonary metastatic loads in treated and untreated animals were as- sessed 30 days post-tumor inoculation, ...
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Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient derived xenograft mouse model
... Patient population and establishment of PDX lines After patients gave informed consent, human breast adenocarcinomas were prospectively collected using a protocol approved by the Institutional Review Board at Washington ...
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