MPT, mitochondrial permeability transition
Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation
... Eosinophils play a crucial role in the pathogenesis of asthma. By releasing toxic granule proteins, lipid media- tors and other proinflammatory components, eosino- phils contribute especially to exacerbations of asthma ...
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Effect of Methanol Leaf Extract of Blighia Sapida on Mitochondrial Membrane Permeability Transition Pore Opening and Blood Glucose Levels in Normal and Streptozotocin-Induced Diabetic Rats
... Diabetes-induced mitochondrial dysfunction subsequently causes increase in free radical production, impaired antioxidant capabilities and dysregulation of mitochondrial permeability transition ...
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Mitochondrial Respiration Is Associated with Alloxan Induced Mitochondrial Permeability Transition
... of MPT is dependent on mitochondrial ATP content ...whether mitochondrial respiration participates in alloxan-induced ...of MPT increases with increasing incubation temperature in that ...
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Cadmium induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition
... 2003). Mitochondrial depolarization in response to cadmium, with the concomitant release of cyt c and activation of caspase- 3-like enzymes, has been demonstrated in all mammalian cell types studied to date, ...
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Imaging the mitochondrial permeability transition in single cells: Free radicals and calcium as determinants of cell fate
... activation. Mitochondrial involvement in apoptotic cell death was confirmed when Liu et al observed that caspase activation in a cell-free system required ATP and cytochrome c (Liu e ta ...the mitochondrial ...
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Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
... major mitochondrial deacetylase that regulates mitochondrial ...metabolism. Mitochondrial proteins are hyperacetylated in SIRT3 knockout mice, but not in SIRT4 or SIRT5 knockout mice ...the ...
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Glycogen synthase kinase 3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
... survival. MPT induction in about one-third of cellular mitochondria by the local photoproduction of ROS (by laser photoexcitation of a precise area within a cell loaded with TMRM) causes approximately two-thirds ...
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Mitochondrial degradation by autophagy (mitophagy) in hepatocytes
... The mitochondrial permeability transition (MPT) is caused by opening of pores in the mitochondrial inner membrane that takes up solutes up to ...membrane. MPT is regulated by ...
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Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... MDR. Mitochondrial permeability transition (mPT) is implicated as an important event in the control of cell death or survival and mPT represents a target for the development of ...
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A mathematical model of mitochondrial swelling
... the MPT as mediated by a pore/channel-like struc- ture ...increased permeability of solutes towards the matrix space causes an osmotically driven water influx ...the mitochondrial inner membrane ...
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Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan
... drial permeability transition (MPT) and mito- chondrial swelling in Cyt c release from mito- chondria treated with alloxan and/or calcium (Ca 2+ ...the MPT was accompa- nied by ...
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Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition
... chondrial permeability transition pore (MPTP) is a protein channel that spans the inner and outer mem- branes of mitochondria ...of mitochondrial membrane potential, which is called ...
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Mitocans as Novel Agents for Anticancer Therapy: An Overview
... outer mitochondrial membrane takes place with dissipation of inner transmembrane potential (∆ψm) and/or release of apoptogenic proteins, such as cyto- chrome c and apoptosis-inducing factor (AIF) via the outer ...
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The effect of quercetin on oxidative stress markers and mitochondrial permeability transition in the heart of rats with type 2 diabetes
... of mitochondrial permeability transi- tion in cardiomyocytes are linked to tissue damage and the development of diabetic cardiovascular complica- ...and mitochondrial permeability ...
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Protective effects of potassium transport in mitochondria from rat myometrium under activation of mitochondrial permeability transition pore
... The suspension was incubated with 40 μM acetoxy methyl ether of PBFI (PBFI-AM) and 0.5 μl of 20% solution of F127 nonionic surfactant for 10 min at room temperature. The suspension was then mixed for 2 min with 500 μl ...
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Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation
... the mitochondrial respiratory chain enzymes and triggers blockade of the electron transfer chain and disruption of the mitochon- drial transmembrane potential (14, ...
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The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria
... Возврат Са 2+ в матрикс после перевода поры в закрытое со- стояние с помощью циклоспорина А также по- казывает, что при открывании поры происхо- дит активация циклического транспорта С[r] ...
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<p>Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening</p>
... MPTP opening usually leads to the release of cytochrome c, subsequently leading to the activation of caspases. Western blot analysis performed by the present study revealed that in the LP treatment group, the expression ...
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Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
... mitochondria. Mitochondrial ROS is produced upon leakage of electrons through complex I (NADH-ubiquinone oxidoreductase) or III (ubiquinone-cytochrome c oxidoreductase) of the mitochondrial respiratory ...
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