mRNA targets
microRNAs in Drosophila regulate cell fate by repressing single mRNA targets
... its mRNA targets through binding to a small primary recognition sequence of 6-8 ...the mRNA but their pres- ence is predominantly in the 3’ untranslated region ...the mRNA (Ghildiyal and ...
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Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69
... a mRNA- specific autogenous translational repressor, in addition to being a sequence-independent ssDNA- binding protein that participates in phage DNA replication, repair and ...natural mRNA targets ...
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A rapid method to screen putative mRNA targets of any known microRNA
... To determine whether the putative binding sequences obtained by hybrid-PCR represent functional target sites for miR-UL112-1, we validated a number of mRNAs using another experimental approach. Six putative bind- ing ...
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Deficiency of the placenta and yolk sac specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism
... ZFP36L3 targets transcripts were identified, as described in detail in the Results ...ZFP36L3 targets, particularly the downregulated ...the mRNA-Seq experiment, with a similar decrease in protein ...
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Epitranscriptome and FMRP Regulated mRNA Translation
... Map1b) mRNA in motor neurons [102], which was re-activated by overexpression of FMRP ...common mRNA targets of FMRP and TDP-43 have been ...160 targets are related to neuron structure, ...
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A sequence based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa
... the mRNA and (ii) those with a single bind- ing site or two closely spaced ( < 10-nt distance) binding ...per mRNA are required for optimal CsrA/RsmA-based repres- ...single mRNA is steri- cally ...
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Circulating micrornas associated with glycemic impairment and progression in Asian Indians
... exact mRNA targets of the miRs that are differentially expressed in Asian Indians with prevalent or incident glycemic impairment compared to healthy ...
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miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors
... Results: Principal component analysis revealed two distinct clusters based on cell type (MSC and MSC-NTFs). Nineteen miRNAs were found to be upregulated and 22 miRNAs were downregulated in MSC-NTF cells relative to the ...
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Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma
... therapeutic targets in ...potential mRNA targets of the 16 miRNAs were ...predicted targets were principally involved in tumor pathogenesis, MAPK signaling, and ...
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Bioinformatic analysis of microRNA and mRNA Regulation in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease
... dysregulated mRNA expression relevant to the pathogenesis of ...and mRNA expression profiles in PBMCs from COPD patients versus smokers without airflow ...The mRNA targets of the dysregulated ...
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Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis
... investigated mRNA targets and was expressed in the majority of all NET of the lung with increasing expression from carcinoids to carcinomas (figure ...
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Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer
... miRNA targets for miR- NAs in the miR-30 family (a-e) (Figure 2B) since these miRNAs have a large number of mRNA ...of targets for miR-30 a-e was 22, 20, 15, 25 and 17, respectively (Table ...be ...
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Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model
... potential mRNA targets of DE miRNAs in MIMs isolated from infected animals, we identified those mRNAs whose expression was significantly negatively correlated with miRNA ...correlated mRNA (Figure 7 ...
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A novel member of the let 7 microRNA family is associated with developmental transitions in filarial nematode parasites
... Predicted mRNA targets of bpa-miR-5364 were identified using bioinformatics and comparative genomics approaches that relied on the conservation of miR-5364 binding sites in the orthologous mRNAs of other ...
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Multiplexed Analysis of Diverse RNA Classes via Hybridization Chain Reaction
... and mRNA targets in fixed whole-mount zebrafish ...one mRNA (hbae3 ). b. miRNA/mRNA ex- pression of targets imaged via confocal microscopy at four planes within an ...
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Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma
... MicroRNA-9 (miR-9) dysregulation is implicated in a variety of human malignancies including hepatocellular carcinoma (HCC), but its role remains contradictory. In this study, we explored the expression and methylation ...
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<p>MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin</p>
... MicroRNAs (miRNAs) are a group of highly conserved single-stranded noncoding RNA molecules that are 17 – 24 nucleotides long. 7 MiRNAs are implicated in gene regulation through the recognition and preferential binding to ...
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A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets
... proposed as a primary mechanism for MYB activation in ACC tumors. Therefore, to test this hypothesis, we performed global unbiased miRNA microarray analyses for the same collection of ACC and adjacent normal tissue ...
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MicroRNA regulatory pathway analysis identifies miR-142-5p as a negative regulator of TGF-β pathway via targeting SMAD3
... prediction and experimental validation (see Methods and Supplementary Figure S1). We used the data of 20 tumor types from TCGA (http://firebrowse.org/), which had miRNA and mRNA expression data in both case ...
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MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer
... Urothelial cell carcinoma of the bladder (UCC) is a common disease often characterized by FGFR3 dysregulation. Whilst upregulation of this oncogene occurs most frequently in low-grade non-invasive tumors, recent data ...
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