MSI-H
<p>Microsatellite Instability-Related <em>ACVR2A</em> Mutations Partially Account for Decreased Lymph Node Metastasis in MSI-H Gastric Cancers</p>
... and MSI status or ACVR2A mutational status was analysed based on a GC dataset from The Cancer Genome Atlas ...with MSI status was ...in MSI-H GCs compared with microsatel- lite instability-low ...
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Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer
... Two years later a CT scan showed significant increase in size of the pelvic soft tissue mass and she was treated with letrozole based on a 30% estrogen receptor positiv- ity identified on histopathological review of the ...
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<p>Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)</p>
... 2 H&E of the excised retroperitoneal lymph node showing poorly differentiated carcinoma, forming cribriform/papillary growth pattern [image 1] and focal clear cell changes [image ...
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Four distinct immune microenvironment subtypes in gastric adenocarcinoma with special reference to microsatellite instability
... all MSI-H GC cases, we performed deep targeted sequencing and obtained good quality sequencing results in 66 ...66 MSI-H GC are described in online supplementary tables ...
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Mutational signatures in colon cancer
... and T > C substitutions occurring with a 5 ′ G (Fig. 1). Both of these signatures resemble signatures previously Fig. 1 Signatures and their estimated mutational exposures for normal ASCs and COAD-US tumors. Six ...
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Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan
... 51 MSI-H and 652 MSI-L/ MSS, available for the status of DNA ploidy, 231 showed DNA diploid ...of MSI-L/MSS tumors showed DNA aneuploidy, but only 27.5% of MSI- H tumors showed ...
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Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial.
... of MSI and MMR protein expression on survival in a randomised trial with a non-chemotherapy control arm for peri- operatively treated gastroesophageal ...either MSI- H or MMRd have superior survival ...
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Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
... [68]. MSI-H colorectal cancers exemplify this attacker/defender model and highlight a pro-immunogenic phenotype which may to some extent be responsible for the more favorable prognosis of patients with ...
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Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease
... Why was pembrolizumab the first anticancer agent to receive tissue-agnostic FDA approval? One likely factor was that the initial randomized pembrolizumab trials conducted across tumor types prioritized tissue collec- ...
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Mutational profiling of colorectal cancers with microsatellite instability
... only MSI-H tumors, but also MSS tumors with ...current MSI assay in this study, may not be able to detect MSI in tumors with extremely low cellularity, where IHC is probably a better ...
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Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
... or MSI-H tumors after progression from prior chemother- apies have been shown in the KEYNOTE-016, 164, 012, 028, and 158 trials ...different MSI-H or dMMR tumors were enrolled in the five ...
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Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population
... with MSI-H had longer PFS than those with MSS/MSI-L (log-rank test: P= ...the MSI-based results, patients with MMR-D also had longer PFS and OS compared with those with MMR-I (log-rank test: ...
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Microsatellite instability: a review of what the oncologist should know
... with MSI-H or dMMR tumors can predict Lynch syndrome through MSI related ...and MSI detec- tion screening are two ways to screen for patients with Lynch syndrome ...[32]. MSI was ...
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DNA repair defects and implications for immunotherapy
... defects, MSI-H has been observed at lower levels across at least 24 different tumor types, and it is estimated that the annual incidence of new MSI-H cancers is in the thousands ...
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Molecular pathology of mismatch repair deficient tumours with emphasis on immune escape mechanisms
... Sporadic MSI-H tumors are usually relatively large, but rarely disseminate ...of MSI-H tumors. [24,38-42]. The MSI of numer- ous coding microsatellites results in a large repertoire of ...
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MSI CIEC: MSI Cyberinfrastructure Empowerment Coalition and the TeraGrid
... Consortium). MSI-CIEC is envisaged as largely aimed at supporting the community interested in CI-involvement of MSI’s and that it will lead just a few projects but also provide a scalable implementation of its ...
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CyberInfrastructure Research/ Education Development at Minority Serving Institutions National Model Promoted/ Implemented by MSI CIEC (Minority Serving Institutions CyberInfrastructure Empowerment Coalition)
... needs, MSI-CIEC provides technical assistance campus visits MSI-CIEC tailored to match the specific computing and networking development plans and needs of selected ...
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HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome
... Immunohistochemical staining and evaluation of cyc- lin D1, p21, p27, p53, and beta-catenin expression has been described previously [15,17]. Immunohistochemical staining for microsatellite instability (MSI) ...
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A Model for LACCEI: Minority Serving Institutions and CyberInfrastructure Research/ Education Minority Serving Institutions CyberInfrastructure Empowerment Coalition MSI CIEC
... There are MSIs that have either made some inroads into CI or have projects that can be CI enabled and with whom MSI-CIEC can assist in expanding their research and curriculum activities. For example, California ...
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Community Grids for Minority Serving Institutions (MSI)
... • Geoffrey Fox: Director of the Community Grids Lab at Indiana University, Visiting Scholar for CI Development at the Alliance for Equity In Higher Education, and Senior Research Associate at CCSDS UHD. PI MSI-CI2 ...
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