mTOR kinase
Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro
... alternative mTOR inhibitors that, unlike rapalogues, are not re- stricted to inhibition of only mTORC1 ...new mTOR inhibi- tors are currently under development. The dual mTOR and PI3K inhibitors ...
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The Changing Role of mTOR Kinase in the Maintenance of Protein Synthesis during Human Cytomegalovirus Infection
... and mTOR inhibition by Torin1 have similar effects on immediate-early, early, and late viral gene ...of mTOR kinase by Torin1 have similar effects on viral protein ...where mTOR kinase ...
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Determination and validation of mTOR kinase-domain 3D structure by homology modeling
... ATP-competitive mTOR and mTOR/PI3K dual inhibitors is mainly 1) aberrantly hyperactive signaling by PI3K/AKT/mTOR is a prominent feature of a broad spectrum of human cancers; 2) rapalogs cause ...
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mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells
... that mTOR kinase inhibitors like pp242 are more effective as compared to Rapa due to their ability to inhibit both complexes - mTORC1 and mTORC2 [18, ...the mTOR kinase inhibitors suppresses ...
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The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
... that mTOR reg- ulates glial inflammatory activation but with selective ...the mTOR pathway have been ...via mTOR dependent proteasomal activa- tion ...and mTOR pathways via integrin receptor ...
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Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors
... and mTOR inhibitors as an effective class and mitigating the risk of off-target effects by using multiple inhibitors across the pathway, as well as siRNA silencing of pathway ...
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Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors.
... and mTOR, respectively ...and mTOR, extending the half-life of MYC and outlining a potential pharmacologic approach for targeting MYC stability [28-30, 34, ...
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The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype
... The cells were lysed in RIPA buffer (1 mM EDTA, 150 mM NaCl, 1% igepal, 0.1% sodium dodecyl sulfate, SDS, 0.5% sodium deoxycholate, 50 mM Tris–HCl, pH 8.0) (Sigma-Aldrich) containing prote- ase inhibitor cocktail diluted ...
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Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species
... The activation of mTORC1 is primarily mediated by the phosphotidylinositol-3 ⬘ -kinase (PI3K)–Akt–tuberous sclero- sis complex (TSC) pathway (Fig. 1B). Activation of PI3K leads to activation of Akt, which ...
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mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma
... differential mTOR kinase inhibitor responses to GBM cells in vitro and in murine ...of mTOR kinase inhibitors in GBM and support the use of DUSP10 expression as a surrogate biomarker to ...
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Indolent peritoneal mesothelioma: PI3K-mTOR inhibitors as a novel therapeutic strategy
... A female aged 28 years presented with abdominal pain, percutaneous biopsy of a 15 cm pelvic mass was reported as a benign highly differentiated adenomatous tumour (table 1). At laparotomy the lesion was only amenable to ...
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März, Andreas (2012): A new player in mTOR regulation: introducing FKBP51. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... reduced mTOR activity in presence of rapamycin compared to FKBP12-overexpressing ...inhibited mTOR kinase activity, indicating that FKBP12 might be ...
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Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
... of mTOR) and mLST8, and upon activation via the upstream PI3K-Akt pathway, has Ser/Thr kinase activity for its main downstream targets S6K1 (ribosomal p70S6 kinase 1), and 4E-BP1 (4E binding protein ...
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Metabolic regulation of lifespan from a C. elegans perspective
... Aging has largely been defined as a gradual decline of functions at the molecular, cellular, tissue, and organis- mal level ultimately leading to disease and death [6, 7]. Despite this complexity, the molecular ...
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Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR
... Background: Vascular smooth muscle cells (VSMC) proliferation contributes significantly to intimal thickening in atherosclerosis and restenosis diseases. Platelet derived growth factor (PDGF) has been implicated in VSMC ...
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PIK3CA activating mutations and chemotherapy sensitivity in stage II–III breast cancer
... (mTOR) [3]. Activation of the PI3K/Akt pathway is involved in the regulation of cell proliferation and suppression of apopto- sis [4]. Activating mutations in the catalytic subunit are onco- genic in vivo [5]. ...
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CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
... tyrosine kinase inhibitor lavendustin A, the phosphatidylinositol3-kinase (PI3-kinase) inhibitor wortmannin, and mTOR/p70s6 kinase inhibitor rapamycin abolished ...p70s6 kinase ...
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Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells
... In order to more directly test the effects of GSK-3a and b individually on p21, we transiently transfected GSK-3 expression vectors into UMUC-14 cells for 48 hours. The exogenous GSK-3b has a slightly higher molecular ...
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Kinase inhibitors as potential agents in the treatment of multiple myeloma
... molecule kinase inhibitors that take advantage of subtle ATP binding site differences have been developed and are used clinically [225], albeit often accompanied by off- target effects, to treat a number of ...
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Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy
... Lentivirus particle production and complementation. siRNA-resistant AMPK ␣ 1 was engineered by silent mutation of the seed sequence sites in the AMPK ␣ 1 cDNA (AGCGGAAGCGTTTCAAATT; seed sequence is in boldface, and ...
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