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mTOR Pathway

The PI3K-AKT-mTOR pathway activates recovery from general anesthesia

The PI3K-AKT-mTOR pathway activates recovery from general anesthesia

... frontal lobe and lateral ventricle, respectively and fixed onto the skull with dental cement to record the cortical EEG activity. Afterwards, all rats were given food and water ad lib., and the room temperature was ...

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Original Article Morphoproteomic Confirmation of a Constitutively Activated mTOR Pathway in High Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer

Original Article Morphoproteomic Confirmation of a Constitutively Activated mTOR Pathway in High Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer

... (mTOR) pathway in the cell cycle progression and growth of prostate cancer ...of mTOR at serine 2448 and to activation of its substrate, p70S6Kinase (p70S6K), phosphorylated on threonine ...the ...

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IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma

IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma

... PI3K/Akt/mTOR pathway is a key player in many types of cancer and its pharmacological targeting via molecular inhibitors is proving to be promising in MB as well ...particular, mTOR is a member of ...

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PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway

PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway

... through mTOR pathway, 3-MA was used in this study, which is demonstrated to inhibit autophagy by blocking autophagosome formation via the inhibition of phosphatidylinositol 3-kinases ...and mTOR, and ...

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Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

... the mTOR downstream signalling path- way is affected systemically in AD patients, rather than just in the ...the mTOR pathway is most likely to be a constitutional characteristic of an ...of ...

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Original Article Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions

Original Article Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions

... and mTOR are also observed in cervical squamous cell carcinoma and, the expression of phosphorylated mTOR was reported to serve as a marker to predict response to chemotherapy and survival of cervical ...

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Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats

Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats

... Materials and methods: Collagen-induced arthritis (CIA) was developed in Wistar rats and used as a model resembling RA in humans. Rats were treated with curcumin (200 mg/kg) and the mTOR inhibitor rapamycin (2.5 ...

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The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

... subtypes), mTOR and PTEN, which function in the PI3K/AKT/mTOR pathway, were selected for further validation of the RNA-Seq ...GPCR, mTOR and PRKCB expression was increased but that Nur77 and ...

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Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

... PI3K/Akt/mTOR pathway via RAGE, while blockage RAGE re-activated PI3K/Akt/ mTOR pathway, however, the addition with PI3K inhibitor redeuced the cell autophagy and improve the cell ...

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The Role of TMEM127 in mTOR Pathway and Cancer Suppression

The Role of TMEM127 in mTOR Pathway and Cancer Suppression

... the mTOR pathway mTOR (mammalian target of rapamycin, mTOR) is a kind of silk/threonine kinase[3, ...[5]. mTOR is considered as an important eukaryotic cell signal, coordinates cell ...

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Original Article NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway

Original Article NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway

... Abstract: Neurensin-2 (NRSN2), a small neural membrane protein which localized in small vesicles in neural cells. Recent report suggested that Neurensin-2 might play a suppressive role in tumor. While the biological ...

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Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

... of mTOR pathway acti- vation in sporadic FCDIIb remains less well understood, with no identified pathogenic ...and mTOR mutations have also been de- tected in epileptic encephalopathies [34] ...

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mTOR pathway in colorectal cancer: an update

mTOR pathway in colorectal cancer: an update

... ATP-competitive mTOR-selective or PI3K/ mTOR dual inhibitors for therapy of CRC patients ...catalytic mTOR inhibitor, pp242, in human colon cancer cell line xenografts ...new-generation mTOR ...

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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

... Two dual inhibitors are under investigation by Novartis (Basel, Switzerland) – NVP-BEZ235 and NVP- BGT226 (there is currently no presented or published data relating to NVP-BGT226). NVP-BEZ235 is an orally available ...

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Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice

Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice

... ing pathway and down-regulation of caspase-3 in rats sub- jected to phototrombic stroke ...ROS/JNK/p53 pathway in colorectal cancer cells ...PI3K/AKT/mTOR pathway, thus such protective ...

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The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats

The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats

... signaling pathway for left ventricular hypertrophy is the Akt / mTOR pathway, so that measuring the expression of the Akt and mTOR genes together with structural changes in the heart can ...

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Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

... Akt/mTOR pathway down-regulation seen in idiopathic autism, since TrkB-FL contains the intracellular catalytic tyrosine kinase domain needed to activate TrkB-mediated signaling cascades, in- cluding the ...

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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology

Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology

... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does its function ...

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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

... Akt/mTOR pathway leads to the development of drug resistance thereby dampening the therapeutic effect of TMZ ...(PI3K)/Akt/rapamycin-sensitive mTOR- complex (mTOR) ...

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SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway

SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway

... and mTOR without impacting their protein expression, which represented an inactivated state of the AKT/mTOR ...AKT/ mTOR signaling pathway is activated very frequently in human cancers through ...

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