mTOR signaling pathway
Oncogenic NanogP8 expression regulates cell proliferation and migration through the Akt/mTOR signaling pathway in human gastric cancer – SGC-7901cell line
... Results: The results indicated that the NanogP8 overexpression promoted proliferation and migra- tion of SGC-7901 cell line, whereas its ablation exerted opposite effects. Interestingly, NanogP8 activated Akt, a key ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... mTOR’s signaling pathway participates in and integrates a variety of environmental cues to control cancer cell and normal tissue ...development. mTOR and its inhibitors including the rapamycin ...
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SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
... AKT/ mTOR signaling pathway, including decreased phosphorylation of AKT and mTOR without affect- ing protein expression, as well as decreased expression of the downstream effector ...
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TRIM44 promotes proliferation and metastasis in non‑small cell lung cancer via mTOR signaling pathway
... The mTOR pathway is important for the regulation of cell proliferation, cell growth, and actin ...and mTOR signaling in esophagogastric cancers [13]; therefore, we reasoned that TRIM44 might ...
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... Currently, the PI3K inhibitors as a single agent or combined with other therapies are being tested in a number of clinical trials (Table 2) [43]. There are pan- PI3K inhibitors and isoform specific PI3K inhibitors [14]. ...
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Original Article Bioinformatics analysis of differentially expressed miRNAs in plasma of respiratory distress syndrome
... For mTOR signaling pathway, Ikeda H et al proved that aberrant activation of the Akt-mTOR pathway in lung epithelium plays a causal role in the pathogenesis of infant RDS, presumably ...
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Essig, Katharina (2019): A global definition of Roquin-mediated regulation of mRNA expression and translation uncovers its impact on PI3K-mTOR signaling and T cell differentiation. Dissertation, LMU München: Medizinische Fakultät
... kinase mTOR, and this finding prompted me to investigate the impact of Roquin on the PI3K- mTOR signaling pathway ...this pathway by regulating its direct targets PTEN and Itch in ...
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Autophagy Promotes Replication of Influenza A Virus In Vitro
... autophagy pathway by modulation of their replication ...HSP90AA1–AKT- mTOR pathway ...AKT-TSC2-mTOR signaling pathway (61), and several viral proteins such as M2, hemagglutinin ...
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Original Article Identification of the clinical diagnostic value of miR-10b-5p and the key targets and pathways in glioma, a study based on meta-analysis and bioinformatics
... metabolic pathway analysis showed the pathways the 124 target genes mainly grouped in the following 6 pathways: MAPK signaling pathway, Oocyte meiosis, Ne- urotrophin signaling pathway, ...
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PubMedCentral-PMC5618757.pdf
... mTOR signaling pathway is involved in EtOH-induced odontogenic differentiation of DPCs, we assessed the acti- vation of mTOR signaling in EtOH-treated DPCs under conditions designed to ...
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Sirt1 Inhibits Adipose Tissue Inflammation by Foxos/ mTOR/S6K1 Signal Pathway in Mice
... of mTOR signaling inhibitor Rapamycin inhibited the activity of mTOR effectively, while Ad-Sirt1 transfection alleviated the inhibition of mTOR activity (Figure ...the mTOR ...
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Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
... PI3K/PTEN/AKT/mTOR pathway is another inter- esting candidate that may impact the host immune response ...AKT-mTOR signaling pathway promotes immune escape by driving the expression of ...
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<p>Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA</p>
... the mTOR signaling pathway can be observed in many malignant tumors, and the mTOR signaling pathway is considered to be a potential target for anti-tumor ...the mTOR ...
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Original Article MiR-29a is down-regulated and inhibits cell proliferation in osteosarcoma: a meta analysis
... Abstract: MiRNAs are a type of small noncoding RNA molecules with 18-25 nucleotides in length. Previous studies demonstrated miRNAs played as key regulators of gene expression and translation by binding to 3’UTR. MiRNA ...
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The Role of TMEM127 in mTOR Pathway and Cancer Suppression
... the signaling pathway and its impact on disease in detail. In the mTOR signaling pathway, TMEM127 regulates cell growth and proliferation, and acts as a tumor suppressor to inhibit ...
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Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
... secretory pathway [16]. In eukaryotic cells, the autophagy-based secretory pathway regulates the unconventional secretion of several cytosolic proteins or factors such as IL (interleu- kin)-1β, IL-18, ...
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Inositol pyrophosphates mediated the apoptosis induced by hypoxic injury in bone marrow-derived mesenchymal stem cells by autophagy
... Inositol polyphosphates are a key signaling molecules in cells [15]. Although most of the more than 30 inositol polyphosphates in mammalian cells have unknown physio- logical functions, a group of higher inositol ...
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PTEN opathies: from biological insights to evidence based precision medicine
... Intriguingly, despite the fact that germline PTEN mutations result in component cancers within a restricted set of organs (36), PTEN somatic driver mutations are enriched in multiple sporadic cancer types that are not ...
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ASSOCIATION LUPUS AND TUBEROUS SCLEROSIS: IS IT POSSIBLE? THE INVOLVEMENT OF MTOR PATHEWAY
... Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against nuclear antigens, and a strong female predominance. It can present with a wide variety of symptoms, ...
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ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells
... of mTOR signaling and an induction of the phosphorylation of the autophagy factor, Unc51-like kinase 1 on ...AMPK pathway leading to autophagy induction of in breast cancer cells, eliciting, in part, ...
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