mTORC1 signaling
Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
... of mTORC1 signaling, ...an mTORC1-dependent manner ...insulin/IGF-1/PI3K/Akt signaling, which further augments mTORC1 ...ERK signaling, which additionally suppresses TSC2 and ...
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Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
... the mTORC1 and MAPK signaling path- ways during the 24 hour post-exercise recovery period in young but not older ...the mTORC1 and MAPK signaling path- ways seems to be an important cellular ...
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The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer
... receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth ...kinase mTORC1 is upregulated in nearly 100% of advanced human ...Oncogenic mTORC1 ...
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Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
... who often develop glucose intolerance and insulin resist- ance [9, 34]. Both TSCmKO and RAmKO mice develop a myopathy and show a reduced body weight, which suggested that they are not able to gain lean and fat mass with ...
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STRADα deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
... Knockdown of STRAD α ameliorates AICAR-mediated inhibition of mTORC1 signaling in a rapamycin-dependent manner. (A–L) Transient STRADα knockdown led to hyperphosphorylation of S6 after AICAR treatment. ...
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Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism
... (TGF-β) signaling pathway to inhibit acute promyelocytic leukemia as well as melanoma bone metastases [13, ...Akt/ mTORC1 signaling both in vitro and in ...Akt/mTORC1 signaling pathway ...
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mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis
... reflects mTORC1 signaling in the developing skeleton (supplementary material ...of mTORC1 signaling indicates that the pathway is likely to play a role in normal skeletal ...
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The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis
... activate mTORC1 signaling, a major regulator of autophagy, may func- tion to dampen the autophagy response to HPV16 E7 expres- sion and limited availability to ...
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Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
... In accordance with previous results, MGMT promoter methylation status was associated with patient survival in the OSAG 101-BSA-05 study cohort [55]. To test if the difference in biological behavior was also reflected by ...
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Host mTORC1 Signaling Regulates Andes Virus Replication
... of mTORC1 and mTORC1 activators but not mTOR complex 2 components reduced ANDV ...increased mTORC1 activity and increased ANDV protein expression, which were blocked following temsirolimus ...that ...
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Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
... Abnormal mTORC1 activation has been implicated in several diseases, including neurodegenerative diseases and cancers ...[13]. mTORC1 dysfunction has been detected during RPE dedifferentiation in mice [14, ...
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
... Skeletal muscle is the largest organ, accounting for 30 to 40% of the total body weight. Muscle tissue is highly plastic and adapts its size to physical demand. For example, increase in load causes hypertrophy whereas ...
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NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
... protein signaling type 4 (RGS4), thus relieving the repression of the Gβγ/PI3Kγ/AKT/mTORC1 pathway that stimulates cardiomyocyte ...AKT/mTORC1 signaling and induction of myocardial hypertrophy ...
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Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
... insulin/IGF-1/PI3K/mTOR signaling pathway either genetically or by treatment with the FDA-approved pharmaceutical rapamycin promotes longevity and inhibits tumor growth in model organisms [7, ...of mTORC1 ...
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N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells
... signaling pathway. To test this hypothesis, we set out to examine the effect of NHPI on mTOR signal- ing pathway in BT-20, LoVo and MDA-MB-231 cells. By western blot analysis, we found that NHPI inhib- ited ...
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New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass
... or mTORC1 signaling, suggesting that changes in PLD activity were not necessary for these events ...and mTORC1 signaling ...of mTORC1 signaling was markedly impaired ...of ...
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GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth
... The single-agent activity of rapalogs (rapamycin and its analogues) in most tumor types has been modest at best. The underlying mechanisms are largely unclear. In this report, we have uncovered a critical role of GSK3 in ...
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I
... AMPK signaling in muscle was impaired under starved conditions, while mTORC1 signaling remained ...AMPK/mTORC1 signaling greatly ameliorated muscle function in HSA LR ...an ...
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Novel role of Rac Mid1 signaling in medial cerebellar development
... of mTORC1 for the promotion of protein synthesis (Nanahoshi et ...in mTORC1 signaling and Map2 expression (dendritogenesis) via Rac KD and ...complexes, mTORC1 and mTORC2, which can be ...
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Regulation of bone formation by baicalein via the mTORC1 pathway
... (mTORC1) signaling pathway, and induced expression of osteoblast differentiation markers, ie, osteocalcin, osterix, collagen Iα1, and runt-related transcription factor 2 (RUNX2), in ...the mTORC1 ...
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